PMID- 24871046
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20211021
IS  - 1432-1440 (Electronic)
IS  - 0946-2716 (Linking)
VI  - 92
IP  - 9
DP  - 2014 Sep
TI  - TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water 
      retention: role in chronic inflammatory diseases with an evolutionary 
      perspective.
PG  - 925-37
LID - 10.1007/s00109-014-1175-9 [doi]
AB  - Chronic inflammatory diseases are accompanied by a systemic response of the body, 
      necessary to redirect energy-rich fuels to the activated immune system and to 
      induce volume expansion. The systemic response is switched on by two major 
      pathways: (a) circulating cytokines enter the brain, and (b) signals via sensory 
      nerve fibers are transmitted to the brain. Concerning item b, sensory nerve 
      terminals are equipped with a multitude of receptors that sense temperature, 
      inflammation, osmolality, and pain. Thus, they can be important to inform the 
      brain about peripheral inflammation. Central to these sensory modalities are 
      transient receptor potential channels (TRP channels) on sensory nerve endings. 
      For example, TRP vanilloid 1 (TRPV1) can be activated by heat, inflammatory 
      factors (e.g., protons, bradykinin, anandamide), hyperosmolality, pungent 
      irritants, and others. TRP channels are multimodal switches that transmit 
      peripheral signals to the brain, thereby inducing a systemic response. It is 
      demonstrated how and why these TRP channels (TRPV1, TRP ankyrin type 1 (TRPA1), 
      and TRP melastatin type 8 (TRPM8)) are important to start up a systemic response 
      of energy expenditure, energy allocation, and water retention and how this is 
      linked to a continuously activated immune system in chronic inflammatory 
      diseases.
FAU - Straub, Rainer H
AU  - Straub RH
AD  - Laboratory of Experimental Rheumatology and Neuroendocrino-Immunology, Division 
      of Rheumatology, Department of Internal Medicine I, University Hospital 
      Regensburg, 93042, Regensburg, Germany, rainer.straub@ukr.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140529
PL  - Germany
TA  - J Mol Med (Berl)
JT  - Journal of molecular medicine (Berlin, Germany)
JID - 9504370
RN  - 0 (Calcium Channels)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (TRPA1 Cation Channel)
RN  - 0 (TRPA1 protein, human)
RN  - 0 (TRPM Cation Channels)
RN  - 0 (TRPM8 protein, human)
RN  - 0 (TRPV Cation Channels)
RN  - 0 (TRPV1 protein, human)
RN  - 0 (Transient Receptor Potential Channels)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Animals
MH  - Calcium Channels/*immunology/metabolism
MH  - Chronic Disease
MH  - Energy Metabolism
MH  - Humans
MH  - Inflammation/*immunology/metabolism/pathology
MH  - Nerve Tissue Proteins/*immunology/metabolism
MH  - TRPA1 Cation Channel
MH  - TRPM Cation Channels/*immunology/metabolism
MH  - TRPV Cation Channels/*immunology/metabolism
MH  - Transient Receptor Potential Channels/*immunology/metabolism
MH  - Water/metabolism
EDAT- 2014/05/30 06:00
MHDA- 2015/04/07 06:00
CRDT- 2014/05/30 06:00
PHST- 2014/02/18 00:00 [received]
PHST- 2014/05/20 00:00 [accepted]
PHST- 2014/05/17 00:00 [revised]
PHST- 2014/05/30 06:00 [entrez]
PHST- 2014/05/30 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - 10.1007/s00109-014-1175-9 [doi]
PST - ppublish
SO  - J Mol Med (Berl). 2014 Sep;92(9):925-37. doi: 10.1007/s00109-014-1175-9. Epub 
      2014 May 29.