PMID- 24871798
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20140816
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 54
DP  - 2014 Oct 3
TI  - Effects of electroconvulsive seizures on depression-related behavior, memory and 
      neurochemical changes in Wistar and Wistar-Kyoto rats.
PG  - 170-8
LID - S0278-5846(14)00103-1 [pii]
LID - 10.1016/j.pnpbp.2014.05.012 [doi]
AB  - BACKGROUND: Investigations in healthy outbred rat strains have shown a potential 
      role for brain-derived neurotrophic factor (BDNF) and the 
      hypothalamic-pituitary-adrenal (HPA) axis in the antidepressant and memory side 
      effects of electroconvulsive therapy (ECT, or ECS in animals). The Wistar-Kyoto 
      (WKY) rat strain is used as a genetic model of depression yet no studies to date 
      have directly compared the impact of ECS on the WKY strain to its healthy outbred 
      control (Wistar). OBJECTIVE: The objective of this study is to examine behavioral 
      (antidepressant and retrograde memory) and neurochemical (BDNF and HPA axis) 
      changes immediately (1day) and at a longer delay (7days) after repeated ECS (5 
      daily administrations) in WKY and Wistar rats. METHODS: Male Wistar and WKY rats 
      received 5days of repeated ECS or sham treatment and were assessed 1 and 7days 
      later for 1) depression-like behavior and mobility; 2) retrograde memory; and 3) 
      brain BDNF protein, brain corticotropin-releasing factor (CRF) and plasma 
      corticosterone levels. RESULTS: Both strains showed the expected antidepressant 
      response and retrograde memory impairments at 1day following ECS, which were 
      sustained at 7days. In addition, at 1day after ECS, Wistar and WKY rats showed 
      similar elevations in brain BDNF and extra-hypothalamic CRF and no change in 
      plasma corticosterone. At 7days after ECS, Wistar rats showed sustained 
      elevations of brain BDNF and CRF, whereas WKY rats showed a normalization of 
      brain BDNF, despite sustained elevations of brain CRF. CONCLUSIONS: The model of 
      5 daily ECS was effective at eliciting behavioral and neurochemical changes in 
      both strains. A temporal association was observed between brain CRF levels, but 
      not BDNF, and measures of antidepressant effectiveness of ECS and retrograde 
      memory impairments suggesting that extra-hypothalamic CRF may be a potential 
      important contributor to these behavioral effects after repeated ECS/ECT.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Kyeremanteng, C
AU  - Kyeremanteng C
AD  - School of Psychology, University of Ottawa, Ottawa, ON K1N 6N5, Canada; 
      University of Ottawa Institute of Mental Health Research, Ottawa, ON K1Z 7K4, 
      Canada.
FAU - MacKay, J C
AU  - MacKay JC
AD  - School of Psychology, University of Ottawa, Ottawa, ON K1N 6N5, Canada; 
      University of Ottawa Institute of Mental Health Research, Ottawa, ON K1Z 7K4, 
      Canada.
FAU - James, J S
AU  - James JS
AD  - University of Ottawa Institute of Mental Health Research, Ottawa, ON K1Z 7K4, 
      Canada.
FAU - Kent, P
AU  - Kent P
AD  - University of Ottawa Institute of Mental Health Research, Ottawa, ON K1Z 7K4, 
      Canada.
FAU - Cayer, C
AU  - Cayer C
AD  - University of Ottawa Institute of Mental Health Research, Ottawa, ON K1Z 7K4, 
      Canada.
FAU - Anisman, H
AU  - Anisman H
AD  - Institute of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada; 
      University of Ottawa Institute of Mental Health Research, Ottawa, ON K1Z 7K4, 
      Canada.
FAU - Merali, Z
AU  - Merali Z
AD  - School of Psychology, University of Ottawa, Ottawa, ON K1N 6N5, Canada; 
      Department of Psychiatry, University of Ottawa, Ottawa, ON K1N 6N5, Canada; 
      Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON 
      K1N 6N5, Canada; University of Ottawa Institute of Mental Health Research, 
      Ottawa, ON K1Z 7K4, Canada. Electronic address: merali@uottawa.ca.
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140525
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Brain/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Corticosterone/blood
MH  - Corticotropin-Releasing Hormone/metabolism
MH  - Depressive Disorder/*physiopathology/psychology/*therapy
MH  - *Electroconvulsive Therapy
MH  - Male
MH  - Memory/*physiology
MH  - Motor Activity/physiology
MH  - Random Allocation
MH  - Rats, Inbred WKY
MH  - Rats, Wistar
MH  - Seizures/etiology/*physiopathology
MH  - Species Specificity
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - BDNF
OT  - Corticotropin-releasing factor
OT  - Depression
OT  - Electroconvulsive therapy
OT  - Memory
EDAT- 2014/05/30 06:00
MHDA- 2015/05/13 06:00
CRDT- 2014/05/30 06:00
PHST- 2014/02/12 00:00 [received]
PHST- 2014/05/05 00:00 [revised]
PHST- 2014/05/20 00:00 [accepted]
PHST- 2014/05/30 06:00 [entrez]
PHST- 2014/05/30 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
AID - S0278-5846(14)00103-1 [pii]
AID - 10.1016/j.pnpbp.2014.05.012 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:170-8. doi: 
      10.1016/j.pnpbp.2014.05.012. Epub 2014 May 25.