PMID- 24871863
OWN - NLM
STAT- MEDLINE
DCOM- 20150916
LR  - 20211021
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 271
IP  - 12
DP  - 2014 Dec
TI  - Long-term trends in gender, T-stage, subsite and treatment for laryngeal cancer 
      at a single center.
PG  - 3233-9
LID - 10.1007/s00405-014-3100-9 [doi]
AB  - To investigate the changes in the epidemiology of laryngeal squamous cell 
      carcinoma (LSCC) regarding gender, T-stage and subsite distribution, and to 
      identify the potential effect of introducing new therapeutic alternatives for 
      early and advanced stage LSCC. A prospective cohort study of LSCC patients 
      diagnosed and treated at a single tertiary referral center in Norway. 
      Retrospective analysis of prospectively recorded data from 1,616 patients treated 
      for LSCC in all subsites of the larynx during 1983-2010. Females represented an 
      increasing proportion of cases throughout the study (p < 0.01) and presented more 
      often than men with supraglottic cancer (p < 0.01). Marked changes in the 
      distribution of T-stages over time were observed in both early and advanced stage 
      LSCC. T1a glottic tumors constituted 56 % of all early-stage LSCC and were 
      predominantly treated by transoral endoscopic laser surgery. The introduction of 
      chemoradiotherapy for advanced stage LSCC offers a distinct advantage for 
      laryngeal preservation. The increasing proportion of females with LSCC may be 
      explained by changes in smoking habits. The proportion of T1a glottic LSCC 
      gradually increased over time, while T4 supraglottic LSCC became less frequent. 
      Videostroboscopy should be considered mandatory in the diagnosis and follow-up of 
      LSCC. Transoral laser microsurgery is the standard first-line treatment for T1a 
      glottic tumors. Chemoradiotherapy has reduced the number of total laryngectomies 
      and is now regarded as the primary treatment for advanced stage tumors.
FAU - Brandstorp-Boesen, Jesper
AU  - Brandstorp-Boesen J
AD  - University of Oslo, Oslo, Norway, jeboesen@ous-hf.no.
FAU - Falk, Ragnhild Sorum
AU  - Falk RS
FAU - Boysen, Morten
AU  - Boysen M
FAU - Brondbo, Kjell
AU  - Brondbo K
LA  - eng
PT  - Journal Article
DEP - 20140529
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Carcinoma, Squamous Cell/epidemiology/pathology/therapy
MH  - Chemoradiotherapy/*methods
MH  - Cohort Studies
MH  - Combined Modality Therapy/methods/statistics & numerical data
MH  - Female
MH  - *Head and Neck Neoplasms/epidemiology/pathology/therapy
MH  - Humans
MH  - Incidence
MH  - *Laryngeal Neoplasms/epidemiology/pathology/therapy
MH  - Laryngectomy/*methods
MH  - *Larynx/pathology/surgery
MH  - Laser Therapy/methods
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Norway/epidemiology
MH  - Prospective Studies
MH  - Sex Factors
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Stroboscopy/methods
EDAT- 2014/05/30 06:00
MHDA- 2015/09/17 06:00
CRDT- 2014/05/30 06:00
PHST- 2014/02/25 00:00 [received]
PHST- 2014/05/08 00:00 [accepted]
PHST- 2014/05/30 06:00 [entrez]
PHST- 2014/05/30 06:00 [pubmed]
PHST- 2015/09/17 06:00 [medline]
AID - 10.1007/s00405-014-3100-9 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2014 Dec;271(12):3233-9. doi: 
      10.1007/s00405-014-3100-9. Epub 2014 May 29.