PMID- 24871931
OWN - NLM
STAT- MEDLINE
DCOM- 20160301
LR  - 20181202
IS  - 2194-9387 (Electronic)
IS  - 2194-9379 (Linking)
VI  - 65
IP  - 2
DP  - 2015 Feb
TI  - HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson 
      Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine 
      case-control studies.
PG  - 107-11
LID - 10.1055/s-0034-1375684 [doi]
AB  - BACKGROUND AND STUDY AIMS: Stevens-Johnson syndrome (SJS) and toxic epidermal 
      necrolysis (TEN) are fatal adverse cutaneous drug reactions which may be induced 
      by phenytoin (PHT) or lamotrigine (LTG). The objective of this study was to 
      analyze the association of human leukocyte antigen (HLA)-B*1502 and PHT or LTG 
      induced SJS/TEN. PATIENTS AND METHODS: All the participants were epileptic 
      patients and the SJS/TEN were induced by PHT or LTG. The presence or absence of 
      the HLA-B*1502 allele of all the patients was determined. ISI Web of Knowledge, 
      PubMed, ScienceDirect, EMBASE, and Cochrane Register of Controlled Trials 
      (CENTRAL) data were searched for the literature published before April 2014. 
      Meta-analysis was performed using Review Manager 5.2 software. RESULTS: From 256 
      citations, 6 English studies were included that involved 480 epilepsy patients. 
      Meta-analysis showed that odd ratio (OR) of PHT and LTG were 5.65 [95% CI: 
      2.76-11.57] and 4.51 [95% CI: 1.57-12.98], respectively. Funnel plot analysis 
      showed symmetry, indicting less possible publication bias and the results were 
      partly reliable. CONCLUSION: There is a significant association between 
      HLA-B*1502 and PHT or LTG-induced SJS/TEN.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Li, X
AU  - Li X
AD  - Department of Pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical 
      University, Beijing, China.
FAU - Yu, K
AU  - Yu K
AD  - Department of Pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical 
      University, Beijing, China.
FAU - Mei, S
AU  - Mei S
AD  - Department of Pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical 
      University, Beijing, China.
FAU - Huo, J
AU  - Huo J
AD  - Department of Pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical 
      University, Beijing, China.
FAU - Wang, J
AU  - Wang J
AD  - Department of Pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical 
      University, Beijing, China.
FAU - Zhu, Y
AU  - Zhu Y
AD  - Department of Pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical 
      University, Beijing, China.
FAU - Zhao, Z
AU  - Zhao Z
AD  - Department of Pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical 
      University, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20140528
PL  - Germany
TA  - Drug Res (Stuttg)
JT  - Drug research
JID - 101602406
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA-B*15:02 antigen)
RN  - 0 (HLA-B15 Antigen)
RN  - 0 (Triazines)
RN  - 6158TKW0C5 (Phenytoin)
RN  - U3H27498KS (Lamotrigine)
SB  - IM
MH  - Anticonvulsants/adverse effects
MH  - Case-Control Studies
MH  - Epilepsy/complications/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - HLA-B15 Antigen/*adverse effects/immunology
MH  - Humans
MH  - Lamotrigine
MH  - Phenytoin/*adverse effects
MH  - Stevens-Johnson Syndrome/*genetics
MH  - Triazines/*adverse effects
EDAT- 2014/05/30 06:00
MHDA- 2016/03/02 06:00
CRDT- 2014/05/30 06:00
PHST- 2014/05/30 06:00 [entrez]
PHST- 2014/05/30 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
AID - 10.1055/s-0034-1375684 [doi]
PST - ppublish
SO  - Drug Res (Stuttg). 2015 Feb;65(2):107-11. doi: 10.1055/s-0034-1375684. Epub 2014 
      May 28.