PMID- 24872079
OWN - NLM
STAT- MEDLINE
DCOM- 20150925
LR  - 20211021
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 122
IP  - 2
DP  - 2015 Feb
TI  - Endogenous serotonin facilitates hippocampal long-term potentiation at CA3/CA1 
      synapses.
PG  - 177-85
LID - 10.1007/s00702-014-1246-7 [doi]
AB  - Encoding of episodic memory requires long-term potentiation (LTP) of 
      neurotransmission at excitatory synapses of the hippocampal circuitry. Previous 
      data obtained with the application of exogenous 5-hydroxytryptamine (5-HT) in 
      hippocampal slices indicate that 5-HT blocks LTP, which contrasts with the 
      facilitatory effect of selective serotonin reuptake inhibitors (SSRIs) on 
      learning and memory observed in vivo. Here, we investigated the effects of 
      endogenous 5-HT, released from terminals by the monoamine releaser 
      3,4-methylenedioxymethamphetamine (MDMA), on LTP of field EPSPs induced by 
      theta-burst stimulation and recorded at CA3/CA1 synapses of rat hippocampal 
      slices. LTP was greater in the presence of MDMA (10 microM; 45.76 +/- 15.75%; n = 28) 
      than in controls (31.26 +/- 11.03; n = 21; p < 0.01). This facilitatory effect on 
      LTP persisted when the entry of MDMA in noradrenergic terminals was prevented by 
      the selective noradrenaline reuptake inhibitor nisoxetine (44.90 +/- 14.07%; n = 27 
      vs. 34.49 +/- 12.94%; n = 20 in controls; p < 0.05). In both conditions, the 
      facilitation of LTP was abolished by the SSRI citalopram that prevented the entry 
      of MDMA in 5-HT terminals and the subsequent 5-HT release. These data show that, 
      unlike exogenous 5-HT application, release of endogenous 5-HT does not impair 
      cellular mechanisms responsible for induction of LTP, indicating that 5-HT is not 
      detrimental to learning and memory. Moreover, facilitation of LTP by endogenous 
      5-HT may underlie the in vivo positive effects of augmented 5-HT tone on 
      cognitive performance.
FAU - Mlinar, Boris
AU  - Mlinar B
AD  - Department of Neuroscience, Psychology, Drug Research and Child Health, 
      University of Florence, Viale G. Pieraccini 6, 50139, Florence, Italy.
FAU - Stocca, Gabriella
AU  - Stocca G
FAU - Corradetti, Renato
AU  - Corradetti R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140529
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Serotonin Agents)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 17NV064B2D (nisoxetine)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Biophysics
MH  - CA1 Region, Hippocampal/*cytology
MH  - CA3 Region, Hippocampal/*cytology
MH  - Electric Stimulation
MH  - Fluoxetine/analogs & derivatives/pharmacology
MH  - In Vitro Techniques
MH  - Long-Term Potentiation/drug effects/*physiology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Nerve Net/drug effects/physiology
MH  - Pyramidal Cells/drug effects/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/*metabolism
MH  - Serotonin Agents/pharmacology
MH  - Synapses/drug effects/*physiology
EDAT- 2014/05/30 06:00
MHDA- 2015/09/26 06:00
CRDT- 2014/05/30 06:00
PHST- 2014/04/07 00:00 [received]
PHST- 2014/05/15 00:00 [accepted]
PHST- 2014/05/30 06:00 [entrez]
PHST- 2014/05/30 06:00 [pubmed]
PHST- 2015/09/26 06:00 [medline]
AID - 10.1007/s00702-014-1246-7 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2015 Feb;122(2):177-85. doi: 10.1007/s00702-014-1246-7. 
      Epub 2014 May 29.