PMID- 24874998
OWN - NLM
STAT- MEDLINE
DCOM- 20141104
LR  - 20220409
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 158
IP  - 3
DP  - 2014 Sep
TI  - Foveal structure-function correlation in children with history of retinopathy of 
      prematurity.
PG  - 508-12.e2
LID - S0002-9394(14)00288-8 [pii]
LID - 10.1016/j.ajo.2014.05.017 [doi]
AB  - PURPOSE: To correlate visual acuity to macular spectral-domain optical coherence 
      tomography (SD OCT) anomalies detected in children with a history of retinopathy 
      of prematurity (ROP). DESIGN: Retrospective cohort study. METHODS: All charts of 
      children with a history of ROP between 2 and 18 years of age and with SD OCT 
      performed between 2010 and 2012 were reviewed. Central foveal thickness was 
      measured and correlated with visual acuity. Secondary outcome measures included 
      temporal parafoveal thickness, presence of the inner nuclear layer and outer 
      segment, gestational age at birth, sex, spherical equivalent, history of laser 
      treatment, and developmental delay. RESULTS: The study included 44 better-seeing 
      eyes of 44 patients. Sixty-four percent (28/44) of patients in our study had 
      20/40 or better visual acuity despite an abnormal foveal morphology in 91% of 
      total eyes. CONCLUSION: Patients with a history of ROP demonstrate a high 
      frequency of macular morphologic abnormalities, including retention of inner 
      retinal layers and absent foveal depression, on SD OCT. These structural changes 
      do not always correlate to visual acuity. Instead it appears that cone maturation 
      may be a better indicator of visual acuity. In addition, there is a significant 
      correlation between best-corrected visual acuity and myopia.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Villegas, Victor M
AU  - Villegas VM
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, Florida.
FAU - Capo, Hilda
AU  - Capo H
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, Florida. Electronic address: 
      hcapo@med.miami.edu.
FAU - Cavuoto, Kara
AU  - Cavuoto K
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, Florida.
FAU - McKeown, Craig A
AU  - McKeown CA
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, Florida.
FAU - Berrocal, Audina M
AU  - Berrocal AM
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, Florida.
LA  - eng
GR  - P30-EY014801/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140527
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - Fovea Centralis/*pathology/*physiopathology
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Retinopathy of Prematurity/diagnosis/*physiopathology
MH  - Retrospective Studies
MH  - Time Factors
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
EDAT- 2014/05/31 06:00
MHDA- 2014/11/05 06:00
CRDT- 2014/05/31 06:00
PHST- 2014/02/21 00:00 [received]
PHST- 2014/05/18 00:00 [revised]
PHST- 2014/05/19 00:00 [accepted]
PHST- 2014/05/31 06:00 [entrez]
PHST- 2014/05/31 06:00 [pubmed]
PHST- 2014/11/05 06:00 [medline]
AID - S0002-9394(14)00288-8 [pii]
AID - 10.1016/j.ajo.2014.05.017 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2014 Sep;158(3):508-12.e2. doi: 10.1016/j.ajo.2014.05.017. Epub 
      2014 May 27.