PMID- 24875951
OWN - NLM
STAT- MEDLINE
DCOM- 20150303
LR  - 20161026
IS  - 0070-217X (Print)
IS  - 0070-217X (Linking)
VI  - 381
DP  - 2014
TI  - Transcriptional control of dendritic cell differentiation.
PG  - 257-78
LID - 10.1007/82_2014_378 [doi]
AB  - Dendritic cells (DCs) are professional antigen presenting cells involved 
      critically not only in provoking innate immune responses but also in establishing 
      adaptive immune responses. Dendritic cells are heterogenous and divided into 
      several subsets, including plasmactyoid DCs (pDCs) and several types of 
      conventional DCs (cDCs), which show subset-specific functions. Plasmactyoid DCs 
      are featured by their ability to produce large amounts of type I interferons 
      (IFNs) in response to nucleic acid sensors, TLR7 and TLR9 and involved in 
      anti-viral immunity and pathogenesis of certain autoimmune disorders such as 
      psoriasis. Conventional DCs include the DC subsets with high crosspresentation 
      activity, which contributes to anti-viral and anti-tumor immunity. These subsets 
      are generated from hematopoietic stem cells (HSCs) via several intermediate 
      progenitors and the development is regulated by the transcriptional mechanisms in 
      which subset-specific transcription factors play major roles. We have recently 
      found that an Ets family transcription factor, SPI-B, which is abundantly 
      expressed in pDCs among DC subsets, plays critical roles in functions and late 
      stage development of pDCs. SPI-B functions in cooperation with other 
      transcription factors, especially, interferon regulatory factor (IRF) family 
      members. Here we review the transcription factor-based molecular mechanisms for 
      generation and functions of DCs, mainly by focusing on the roles of SPI-B and its 
      relatives.
FAU - Sasaki, Izumi
AU  - Sasaki I
AD  - Laboratory for Immune Regulation, WPI Immunology Frontier Research Center, Osaka 
      University, Yamadaoka 3-1, Suita, Osaka, 565-0871, Japan.
FAU - Kaisho, Tsuneyasu
AU  - Kaisho T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Curr Top Microbiol Immunol
JT  - Current topics in microbiology and immunology
JID - 0110513
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - *Cell Differentiation
MH  - Dendritic Cells/*cytology/*metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Transcription Factors/genetics/*metabolism
MH  - *Transcription, Genetic
EDAT- 2014/05/31 06:00
MHDA- 2015/03/04 06:00
CRDT- 2014/05/31 06:00
PHST- 2014/05/31 06:00 [entrez]
PHST- 2014/05/31 06:00 [pubmed]
PHST- 2015/03/04 06:00 [medline]
AID - 10.1007/82_2014_378 [doi]
PST - ppublish
SO  - Curr Top Microbiol Immunol. 2014;381:257-78. doi: 10.1007/82_2014_378.