PMID- 24877042
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140530
LR  - 20220408
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 10
IP  - 2
DP  - 2014 Apr
TI  - Treadmill exercise alleviates impairment of spatial learning ability through 
      enhancing cell proliferation in the streptozotocin-induced Alzheimer's disease 
      rats.
PG  - 81-8
LID - 10.12965/jer.140102 [doi]
AB  - Alzheimer's disease is the most common cause of dementia. This disease is a 
      progressive and irreversible brain disorder accompanied with severe learning and 
      memory impairment. Exercise increases cognitive ability, attenuates motor 
      deficits, increases new neuron formation, and ameliorates neurological 
      impairments in several neurodegenerative diseases. This study investigated the 
      effects of treadmill exercise on spatial learning ability in relation with cell 
      proliferation in the hippocampus. The rat model of Alzheimer's disease was 
      induced by intracerebroventricular (ICV) injection of streptozotocin (STZ) using 
      a stereotaxic instrument. The rats in the exercise groups were forced to run on a 
      treadmill for once 30 min daily for 28 consecutive days starting at 3 days after 
      the ICV injection of STZ. Radial 8-arm maze test was conducted for the spatial 
      learning ability. New neuron formation in the hippocampus was detected by 
      5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry. Brain-derived neurotrophic 
      factor (BDNF) and tyrosine kinase B (TrkB) expressions were examined by western 
      blot analysis. The present results show that ICV injection of STZ impaired 
      spatial learning ability. Decreased cell proliferation with decrement of BDNF and 
      TrkB expressions in the hippocampus were observed in the STZ-induced Alzheimer's 
      disease rats. However, treadmill exercise alleviated deficits of spatial learning 
      ability. Treadmill exercise enhanced cell proliferation and increased BDNF and 
      TrkB expressions in the rats with ICV injection of STZ. The present study 
      suggests that treadmill exercise can be a useful strategy for treating memory 
      impairment induced by several neurodegenerative diseases.
FAU - Sim, Young-Je
AU  - Sim YJ
AD  - Department of Physical Education, Kunsan National University, Gunsan, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140430
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC4025554
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Brain-derived neurotrophic factor
OT  - Cell proliferation
OT  - Spatial learning ability
OT  - Treadmill exercise
EDAT- 2014/05/31 06:00
MHDA- 2014/05/31 06:01
PMCR- 2014/04/30
CRDT- 2014/05/31 06:00
PHST- 2014/04/17 00:00 [received]
PHST- 2014/04/21 00:00 [accepted]
PHST- 2014/05/31 06:00 [entrez]
PHST- 2014/05/31 06:00 [pubmed]
PHST- 2014/05/31 06:01 [medline]
PHST- 2014/04/30 00:00 [pmc-release]
AID - jer-10-2-81-6 [pii]
AID - 10.12965/jer.140102 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2014 Apr 30;10(2):81-8. doi: 10.12965/jer.140102. eCollection 
      2014 Apr.