PMID- 24878112 OWN - NLM STAT- MEDLINE DCOM- 20150123 LR - 20211021 IS - 1360-0451 (Electronic) IS - 0954-0121 (Print) IS - 0954-0121 (Linking) VI - 26 IP - 11 DP - 2014 TI - Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV. PG - 1327-35 LID - 10.1080/09540121.2014.920949 [doi] AB - Human immunodeficiency virus (HIV)-negative children born to HIV-infected mothers may exhibit differences in neurodevelopment (ND) compared to age- and gender-matched controls whose lives have not been affected by HIV. This could occur due to exposure to HIV and antiretroviral agents in utero and perinatally, or differences in the environment in which they grow up. This study assessed neurodevelopmental outcomes in HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) children enrolled as controls in a multicenter ND study from Thailand and Cambodia. One hundred sixty HEU and 167 HUU children completed a neurodevelopmental assessment using the Beery Visual Motor Integration (VMI) test, Color Trails, Perdue Pegboard, and Child Behavior Checklist (CBCL). Thai children (n = 202) also completed the Wechsler Intelligence Scale (IQ) and Stanford-Binet II memory tests. In analyses adjusted for caregiver education, parent as caregiver, household income, age, and ethnicity, statistically significant lower scores were seen on verbal IQ (VIQ), full-scale IQ (FSIQ), and Binet Bead Memory among HEU compared to HUU. The mean (95% CI) differences were -6.13 (-10.3 to -1.96), p = 0.004; -4.57 (-8.80 to -0.35), p = 0.03; and -3.72 (-6.57 to -0.88), p = 0.01 for VIQ, FSIQ, and Binet Bead Memory, respectively. We observed no significant differences in performance IQ, other Binet memory domains, Color Trail, Perdue Pegboard, Beery VMI, or CBCL test scores. We conclude that HEU children evidence reductions in some neurodevelopmental outcomes compared to HUU; however, these differences are small and it remains unclear to what extent they have immediate and long-term clinical significance. FAU - Kerr, Stephen J AU - Kerr SJ AD - a HIV-NAT , The Thai Red Cross AIDS Research Centre , Bangkok , Thailand. FAU - Puthanakit, Thanyawee AU - Puthanakit T FAU - Vibol, Ung AU - Vibol U FAU - Aurpibul, Linda AU - Aurpibul L FAU - Vonthanak, Sophan AU - Vonthanak S FAU - Kosalaraksa, Pope AU - Kosalaraksa P FAU - Kanjanavanit, Suparat AU - Kanjanavanit S FAU - Hansudewechakul, Rawiwan AU - Hansudewechakul R FAU - Wongsawat, Jurai AU - Wongsawat J FAU - Luesomboon, Wicharn AU - Luesomboon W FAU - Ratanadilok, Kattiya AU - Ratanadilok K FAU - Prasitsuebsai, Wasana AU - Prasitsuebsai W FAU - Pruksakaew, Kanchana AU - Pruksakaew K FAU - van der Lugt, Jasper AU - van der Lugt J FAU - Paul, Robert AU - Paul R FAU - Ananworanich, Jintanat AU - Ananworanich J FAU - Valcour, Victor AU - Valcour V CN - SEARCH 012 Study Team LA - eng GR - R01 MH089722/MH/NIMH NIH HHS/United States GR - U19 AI053741/AI/NIAID NIH HHS/United States GR - U19 AI53741/AI/NIAID NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural DEP - 20140530 PL - England TA - AIDS Care JT - AIDS care JID - 8915313 RN - 0 (Anti-Retroviral Agents) SB - IM MH - Anti-Retroviral Agents/*therapeutic use MH - Cambodia/epidemiology MH - Case-Control Studies MH - Child MH - *Child Development MH - Child, Preschool MH - Cognition/drug effects MH - Enzyme-Linked Immunosorbent Assay MH - Female MH - HIV Infections/*drug therapy/psychology MH - Humans MH - Infant MH - Infant, Newborn MH - Infectious Disease Transmission, Vertical MH - Intelligence Tests/*statistics & numerical data MH - Male MH - Nervous System Diseases/*chemically induced MH - Neuropsychological Tests/*statistics & numerical data MH - Pregnancy MH - Pregnancy Complications, Infectious/drug therapy MH - Prenatal Exposure Delayed Effects/epidemiology MH - Thailand/epidemiology PMC - PMC4122621 MID - NIHMS603147 OTO - NOTNLM OT - HIV OT - children OT - neurodevelopment OT - resource-limited setting FIR - Ananworanich, Jintanat IR - Ananworanich J FIR - Puthanakit, Thanyawee IR - Puthanakit T FIR - Bunupradah, Torsak IR - Bunupradah T FIR - Kerr, Stephen IR - Kerr S FIR - Ubolyam, Sasiwimol IR - Ubolyam S FIR - Laopraynak, Naphassanant IR - Laopraynak N FIR - Suwanlerk, Tulathip IR - Suwanlerk T FIR - Prusakaew, Kanchana IR - Prusakaew K FIR - Ratanadilok, Kattiya IR - Ratanadilok K FIR - Pothipala, Varaporn IR - Pothipala V FIR - Nanthapisal, Kesdao IR - Nanthapisal K FIR - Valcour, Victor IR - Valcour V FIR - Catella, Stephanie IR - Catella S FIR - Desai, Akash IR - Desai A FIR - Wendelken-Riegelhaupt, Lauren IR - Wendelken-Riegelhaupt L FIR - Busovaca, Edgar IR - Busovaca E FIR - Phanuphak, Praphan IR - Phanuphak P FIR - Cooper, David A IR - Cooper DA FIR - Kaldor, John IR - Kaldor J FIR - Vun, Mean Chhi IR - Vun MC FIR - Vonthanak, Saphonn IR - Vonthanak S FIR - Ruxrungtham, Kiat IR - Ruxrungtham K FIR - Giaquinto, Carlo IR - Giaquinto C FIR - Cotton, Mark IR - Cotton M FIR - Lolekha, Rangsima IR - Lolekha R FIR - Sirisanthana, Virat IR - Sirisanthana V FIR - Chokephaibulkit, Kulkanya IR - Chokephaibulkit K FIR - Suntarattiwong, Piyarat IR - Suntarattiwong P FIR - Volberding, Paul IR - Volberding P FIR - Bangdiwala, Shrikant IR - Bangdiwala S FIR - Lim, Kruy IR - Lim K FIR - David, N M Samuel IR - David NM FIR - Solomon, Suniti IR - Solomon S FIR - Suwangool, Panpit IR - Suwangool P FIR - Wang, Ruotao IR - Wang R FIR - Zhang, Fujie IR - Zhang F FIR - Zoloth, Laurie IR - Zoloth L FIR - Dixon, Dennis O IR - Dixon DO FIR - Fox, Lawrence IR - Fox L FIR - Ojumu, Akinlolu O IR - Ojumu AO FIR - Bupp, Jane E IR - Bupp JE FIR - Ussery, Michael IR - Ussery M FIR - Wetherall, Neal T IR - Wetherall NT FIR - Brouwers, Pim IR - Brouwers P FIR - Mofenson, Lynne M IR - Mofenson LM FIR - Douoguih, Macaya IR - Douoguih M FIR - Petrakova, Eva IR - Petrakova E FIR - Law, Matthew IR - Law M FIR - Shearer, William T IR - Shearer WT FIR - Valcour, Victor IR - Valcour V FIR - Paul, Rober IR - Paul R FIR - Pattanapanyasat, Kovit IR - Pattanapanyasat K FIR - Sakulploy, Natthaga IR - Sakulploy N FIR - McNicholl, Janet M IR - McNicholl JM FIR - Saisaengjan, Chutima IR - Saisaengjan C FIR - Rattanadilok, Kattiya IR - Rattanadilok K FIR - Ruxrungtham, Kiat IR - Ruxrungtham K FIR - Ananworanich, Jintanat IR - Ananworanich J FIR - Puthanakit, Thanyawee IR - Puthanakit T FIR - Pancharoen, Chitsanu IR - Pancharoen C FIR - Bunupuradah, Torsak IR - Bunupuradah T FIR - van der Lugt, Jasper IR - van der Lugt J FIR - Prasitsuebsai, Wasana IR - Prasitsuebsai W FIR - Kerr, Stephen IR - Kerr S FIR - Chuenyam, Theshinee IR - Chuenyam T FIR - Ubolyam, Sasiwimol IR - Ubolyam S FIR - Mahanontharit, Apicha IR - Mahanontharit A FIR - Suwanlerk, Tulathip IR - Suwanlerk T FIR - Intasan, Jintana IR - Intasan J FIR - Jupimai, Thidarat IR - Jupimai T FIR - Hirunyanulux, Tawan IR - Hirunyanulux T FIR - Pinklow, Praneet IR - Pinklow P FIR - Pruksakaew, Kanchana IR - Pruksakaew K FIR - Butterworth, Oratai IR - Butterworth O FIR - Sriheara, Chulalak IR - Sriheara C FIR - Uanithirat, Anuntaya IR - Uanithirat A FIR - 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Lulitanond V FIR - Khahmahpahte, Samrit IR - Khahmahpahte S FIR - Kaewmart, Ratthanant IR - Kaewmart R FIR - Chaimanee, Prajuab IR - Chaimanee P FIR - Sala, Mathurot IR - Sala M FIR - Udompanit, Thaniita IR - Udompanit T FIR - Wisai, Ratchadaporn IR - Wisai R FIR - Rattanamanee, Somjai IR - Rattanamanee S FIR - Chantarasuk, Yingrit IR - Chantarasuk Y FIR - Sarvok, Sompong IR - Sarvok S FIR - Changtrakun, Yotsombat IR - Changtrakun Y FIR - Kunhasura, Soontorn IR - Kunhasura S FIR - Kamollert, Sudthanom IR - Kamollert S FIR - Singkhornard, Jintana IR - Singkhornard J FIR - Unprai, Peerada IR - Unprai P FIR - Udomsri, Chonnikarn IR - Udomsri C FIR - Luesomboon, Wicharn IR - Luesomboon W FIR - Eiamapichart, Pairuch IR - Eiamapichart P FIR - Jadwattanakul, Tanate IR - Jadwattanakul T FIR - Limpet-ngam, Isara IR - Limpet-ngam I FIR - Naraporn, Daovadee IR - Naraporn D FIR - Mathajittiphun, Pornpen IR - Mathajittiphun P FIR - Sirimaskul, Chatchadha IR - Sirimaskul C FIR - Klaihong, Woranun IR - 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Chettra K FIR - Phary, Lim IR - Phary L FIR - Roeun, Toun IR - Roeun T FIR - Sunly, Tieng IR - Sunly T FIR - Chandara, Mom IR - Chandara M FIR - Sokheng, Chuop IR - Sokheng C FIR - Sokoeun, Khin IR - Sokoeun K FIR - Sotharin, Tuey IR - Sotharin T FIR - Vonthanak, Saphonn IR - Vonthanak S FIR - Vibol, Ung IR - Vibol U FIR - Bun, Vannary IR - Bun V FIR - ChhayMeng, Somanythd IR - ChhayMeng S FIR - Chettra, Kea IR - Chettra K FIR - Phan, Sam IR - Phan S FIR - vong, Wuddhika In IR - vong WI FIR - Dyna, Khuon IR - Dyna K FIR - Ngampiyaskul, Chaiwat IR - Ngampiyaskul C FIR - Srisawat, Naowarat IR - Srisawat N FIR - Chamjamrat, Wanna IR - Chamjamrat W FIR - Wattanayothin, Sayamol IR - Wattanayothin S FIR - Prasertphan, Pornphan IR - Prasertphan P FIR - Wongcheeree, Tanyamon IR - Wongcheeree T FIR - Greetanukroh, Pisut IR - Greetanukroh P FIR - Imubumroong, Chataporn IR - Imubumroong C FIR - Teirsonsern, Pathanee IR - Teirsonsern P FIR - Khantilapapan, Nittaya IR - Khantilapapan N FIR - Deenarn, Petcharat IR - Deenarn P FIR - Charoenvikkai, Bhensiri IR - Charoenvikkai B EDAT- 2014/06/01 06:00 MHDA- 2015/01/24 06:00 PMCR- 2015/11/01 CRDT- 2014/06/01 06:00 PHST- 2014/06/01 06:00 [entrez] PHST- 2014/06/01 06:00 [pubmed] PHST- 2015/01/24 06:00 [medline] PHST- 2015/11/01 00:00 [pmc-release] AID - 10.1080/09540121.2014.920949 [doi] PST - ppublish SO - AIDS Care. 2014;26(11):1327-35. doi: 10.1080/09540121.2014.920949. Epub 2014 May 30.