PMID- 24878474
OWN - NLM
STAT- MEDLINE
DCOM- 20160629
LR  - 20190902
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 41
IP  - 4
DP  - 2014 Jul
TI  - Impact of glucose fluctuation on acute cerebral infarction in type 2 diabetes.
PG  - 486-92
AB  - OBJECTIVE: This study aimed to describe the frequency and temporal profile of 
      acute cerebral infarction (ACI) using a continuous glucose monitoring system 
      (CGMS) in patients with and without type 2 diabetes mellitus (T2DM) and explore 
      the impact of blood glucose fluctuations on the short-term prognosis of ACI. 
      METHODS: The subjects were divided into four groups: T2DM with acute cerebral 
      infarction (DMCI, Group A, n=56); T2DM without acute cerebral infarction (DM-NCI, 
      Group B, n=36); Acute cerebral infarction patients without T2DM (NDM-CI, Group C, 
      n=54); Healthy control group (NG, Group D, n=36). The National Institutes of 
      Health Stoke Scale (NIHSS) and modified Rankin scale (mRs) were collected in 
      Group A and C. All subjects were monitored for 72 hours using the CGMS. Indices 
      such as fasting blood glucose (FBG) and mean amplitude of glycemic excursions 
      (MAGE) were calculated. Glycemic excursions were compared between Group A, B, C 
      and Group D, respectively. Multiple linear regression analysis and logistic 
      analysis was applied. RESULTS: MAGE is related to NIHSS, homocysteine (HCY), 
      HOMA-IR, FBG, CRP and IMT, while NIHSS is related to CRP, HCY, HOMA-IR, IMT. The 
      factors impacting the short-term prognosis of ACI were NIHSS, HBA1C and MAGE. 
      CONCLUSION: Larger glucose fluctuations are associated with more stroke risk 
      factors and are associated with a poorer short-term prognosis. More attention 
      should be paid to glucose fluctuations in patients with ACI and a history of 
      T2DM.
FAU - Huang, Jinxin
AU  - Huang J
FAU - Zhang, Xingguang
AU  - Zhang X
FAU - Li, Juan
AU  - Li J
FAU - Tang, Liya
AU  - Tang L
FAU - Jiao, Xiumin
AU  - Jiao X
FAU - Lv, Xiaofeng
AU  - Lv X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences 
      neurologiques
JID - 0415227
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Blood Glucose/*metabolism
MH  - Blood Glucose Self-Monitoring/trends
MH  - Cerebral Infarction/*blood/*diagnosis/epidemiology
MH  - Diabetes Mellitus, Type 2/*blood/*diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2014/06/01 06:00
MHDA- 2016/06/30 06:00
CRDT- 2014/06/01 06:00
PHST- 2014/06/01 06:00 [entrez]
PHST- 2014/06/01 06:00 [pubmed]
PHST- 2016/06/30 06:00 [medline]
AID - F16647603U017N72 [pii]
AID - 10.1017/s0317167100018539 [doi]
PST - ppublish
SO  - Can J Neurol Sci. 2014 Jul;41(4):486-92. doi: 10.1017/s0317167100018539.