PMID- 24879944
OWN - NLM
STAT- MEDLINE
DCOM- 20141104
LR  - 20140818
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 158
IP  - 3
DP  - 2014 Sep
TI  - A longitudinal comparison of spectral-domain optical coherence tomography and 
      fundus autofluorescence in geographic atrophy.
PG  - 557-66.e1
LID - S0002-9394(14)00298-0 [pii]
LID - 10.1016/j.ajo.2014.05.026 [doi]
AB  - PURPOSE: To identify reliable criteria based on spectral-domain optical coherence 
      tomography (SD OCT) to monitor disease progression in geographic atrophy 
      attributable to age-related macular degeneration (AMD) compared with lesion size 
      determination based on fundus autofluorescence (FAF). DESIGN: Prospective 
      longitudinal observational study. METHODS: setting: Institutional. study 
      population: A total of 48 eyes in 24 patients with geographic atrophy. 
      observation procedures: Eyes with geographic atrophy were included and examined 
      at baseline and at months 3, 6, 9, and 12. At each study visit best-corrected 
      visual acuity (BCVA), FAF, and SD OCT imaging were performed. FAF images were 
      analyzed using the region overlay device. Planimetric measurements in SD OCT, 
      including alterations or loss of outer retinal layers and the RPE, as well as 
      choroidal signal enhancement, were performed with the OCT Toolkit. main outcome 
      measures: Areas of interest in patients with geographic atrophy measured from 
      baseline to month 12 by SD OCT compared with the area of atrophy measured by FAF. 
      RESULTS: Geographic atrophy lesion size increased from 8.88 mm(2) to 11.22 mm(2) 
      based on quantitative FAF evaluation. Linear regression analysis demonstrated 
      that results similar to FAF planimetry for determining lesion progression can be 
      obtained by measuring the areas of outer plexiform layer thinning (adjusted 
      R(2) = 0.93), external limiting membrane loss (adjusted R(2) = 0.89), or 
      choroidal signal enhancement (R(2) = 0.93) by SD OCT. CONCLUSIONS: SD OCT allows 
      morphologic markers of disease progression to be identified in geographic atrophy 
      and may improve understanding of the pathophysiology of atrophic AMD.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Simader, Christian
AU  - Simader C
AD  - Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, 
      Vienna, Austria; Department of Ophthalmology, Medical University of Vienna, 
      Vienna, Austria.
FAU - Sayegh, Ramzi G
AU  - Sayegh RG
AD  - Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, 
      Vienna, Austria; Department of Ophthalmology, Medical University of Vienna, 
      Vienna, Austria. Electronic address: ramzi.sayegh@meduniwien.ac.at.
FAU - Montuoro, Alessio
AU  - Montuoro A
AD  - Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, 
      Vienna, Austria.
FAU - Azhary, Malek
AU  - Azhary M
AD  - Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, 
      Vienna, Austria.
FAU - Koth, Anna Lucia
AU  - Koth AL
AD  - Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, 
      Vienna, Austria.
FAU - Baratsits, Magdalena
AU  - Baratsits M
AD  - Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
FAU - Sacu, Stefan
AU  - Sacu S
AD  - Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
FAU - Prunte, Christian
AU  - Prunte C
AD  - Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
FAU - Kreil, David P
AU  - Kreil DP
AD  - Department of Biotechnology, University of Natural Resources and Life Sciences, 
      Vienna, Austria; School of Life Sciences, University of Warwick, Coventry, UK.
FAU - Schmidt-Erfurth, Ursula
AU  - Schmidt-Erfurth U
AD  - Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, 
      Vienna, Austria; Department of Ophthalmology, Medical University of Vienna, 
      Vienna, Austria.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
DEP - 20140528
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease Progression
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Geographic Atrophy/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Pigment Epithelium/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
EDAT- 2014/06/01 06:00
MHDA- 2014/11/05 06:00
CRDT- 2014/06/01 06:00
PHST- 2013/01/12 00:00 [received]
PHST- 2014/05/19 00:00 [revised]
PHST- 2014/05/21 00:00 [accepted]
PHST- 2014/06/01 06:00 [entrez]
PHST- 2014/06/01 06:00 [pubmed]
PHST- 2014/11/05 06:00 [medline]
AID - S0002-9394(14)00298-0 [pii]
AID - 10.1016/j.ajo.2014.05.026 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2014 Sep;158(3):557-66.e1. doi: 10.1016/j.ajo.2014.05.026. Epub 
      2014 May 28.