PMID- 24879947
OWN - NLM
STAT- MEDLINE
DCOM- 20141104
LR  - 20140818
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 158
IP  - 3
DP  - 2014 Sep
TI  - Optical coherence tomography retinal thickness and volume measurements in 
      X-linked retinoschisis.
PG  - 567-73.e2
LID - S0002-9394(14)00300-6 [pii]
LID - 10.1016/j.ajo.2014.05.028 [doi]
AB  - PURPOSE: To analyze retinal thickness and volume measurements of X-linked 
      retinoschisis patients by spectral-domain optical coherence tomography (SD OCT) 
      and correlate these findings with visual acuity and patient age. DESIGN: 
      Retrospective comparative case series. METHODS: Sixty-three eyes of 33 male 
      patients with X-linked retinoschisis were gleaned from a SD OCT database at the 
      University of Illinois at Chicago. Forty-one eyes of 21 patients with low 
      refractive error, no visual impairment, and no known retinal disease served as 
      age-similar controls. The mean age of the retinoschisis patients was 26.4 years. 
      The mean age of patient controls was 30.0 years. Full-thickness, inner and outer 
      retina thickness, and volume measurements were determined by SD OCT. RESULTS: 
      Foveal schisis was observed in 81% of retinoschisis patients. Patients with 
      foveal schisis tended to be younger than patients lacking foveal schisis. Inner 
      and outer foveal thickness and volume measurements were increased in 
      retinoschisis patients compared to controls. Outer retinal perifoveal and 
      parafoveal thicknesses and volumes were consistently increased in retinoschisis 
      patients relative to controls. In contrast, inner retinal perifoveal and 
      parafoveal thickness and volume measurements were decreased in retinoschisis 
      patients compared to controls. Worse visual acuity correlated with thinning of 
      the temporal perifoveal inner retina and thickening of the inner fovea. 
      Full-thickness measurements and inner retina and outer retina thickness and 
      volume measurements tended to decrease with patient age. CONCLUSION: Increased 
      inner retinal foveal thickness and decreased perifoveal inner retinal thickness 
      correlates with worse visual acuity and overall retinal thickness decreases with 
      age in X-linked retinoschisis.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Andreoli, Michael T
AU  - Andreoli MT
AD  - Illinois Eye and Ear Infirmary, University of Illinois at Chicago Department of 
      Ophthalmology and Visual Sciences, Chicago, Illinois.
FAU - Lim, Jennifer I
AU  - Lim JI
AD  - Illinois Eye and Ear Infirmary, University of Illinois at Chicago Department of 
      Ophthalmology and Visual Sciences, Chicago, Illinois. Electronic address: 
      jennylim@uic.edu.
LA  - eng
GR  - EY01792/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140528
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Disease Progression
MH  - Female
MH  - Fovea Centralis/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retina/*pathology
MH  - Retinoschisis/*diagnosis
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
MH  - Young Adult
EDAT- 2014/06/01 06:00
MHDA- 2014/11/05 06:00
CRDT- 2014/06/01 06:00
PHST- 2014/02/10 00:00 [received]
PHST- 2014/05/21 00:00 [revised]
PHST- 2014/05/22 00:00 [accepted]
PHST- 2014/06/01 06:00 [entrez]
PHST- 2014/06/01 06:00 [pubmed]
PHST- 2014/11/05 06:00 [medline]
AID - S0002-9394(14)00300-6 [pii]
AID - 10.1016/j.ajo.2014.05.028 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2014 Sep;158(3):567-73.e2. doi: 10.1016/j.ajo.2014.05.028. Epub 
      2014 May 28.