PMID- 24880215
OWN - NLM
STAT- MEDLINE
DCOM- 20140822
LR  - 20220309
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 17
IP  - 7
DP  - 2014 Jul
TI  - Functional organization of glomerular maps in the mouse accessory olfactory bulb.
PG  - 953-61
LID - 10.1038/nn.3738 [doi]
AB  - The mammalian accessory olfactory system extracts information about species, sex 
      and individual identity from social odors, but its functional organization 
      remains unclear. We imaged presynaptic Ca(2+) signals in vomeronasal inputs to 
      the accessory olfactory bulb (AOB) during peripheral stimulation using light 
      sheet microscopy. Urine- and steroid-responsive glomeruli densely innervated the 
      anterior AOB. Glomerular activity maps for sexually mature female mouse urine 
      overlapped maps for juvenile and/or gonadectomized urine of both sexes, whereas 
      maps for sexually mature male urine were highly distinct. Further spatial 
      analysis revealed a complicated organization involving selective juxtaposition 
      and dispersal of functionally grouped glomerular classes. Glomeruli that were 
      similarly tuned to urines were often closely associated, whereas more disparately 
      tuned glomeruli were selectively dispersed. Maps to a panel of sulfated steroid 
      odorants identified tightly juxtaposed groups that were disparately tuned and 
      dispersed groups that were similarly tuned. These results reveal a modular, 
      nonchemotopic spatial organization in the AOB.
FAU - Hammen, Gary F
AU  - Hammen GF
AD  - 1] Department of Anatomy and Neurobiology, Washington University School of 
      Medicine, St. Louis, Missouri, USA. [2] MD-PhD Program, Washington University 
      School of Medicine, St. Louis, Missouri, USA.
FAU - Turaga, Diwakar
AU  - Turaga D
AD  - 1] Department of Anatomy and Neurobiology, Washington University School of 
      Medicine, St. Louis, Missouri, USA. [2] MD-PhD Program, Washington University 
      School of Medicine, St. Louis, Missouri, USA.
FAU - Holy, Timothy E
AU  - Holy TE
AD  - 1] Department of Anatomy and Neurobiology, Washington University School of 
      Medicine, St. Louis, Missouri, USA. [2].
FAU - Meeks, Julian P
AU  - Meeks JP
AUID- ORCID: 0000000275374491
AD  - 1] Department of Neuroscience, The University of Texas Southwestern Medical 
      Center, Dallas, Texas, USA. [2].
LA  - eng
GR  - R01 NS068409/NS/NINDS NIH HHS/United States
GR  - R01 DC010381/DC/NIDCD NIH HHS/United States
GR  - F32DC009352/DC/NIDCD NIH HHS/United States
GR  - R00 DC011780/DC/NIDCD NIH HHS/United States
GR  - R01DC010381/DC/NIDCD NIH HHS/United States
GR  - F32 DC009352/DC/NIDCD NIH HHS/United States
GR  - K99/R00DC011780/DC/NIDCD NIH HHS/United States
GR  - R01NS068409/NS/NINDS NIH HHS/United States
GR  - R01 DC005964/DC/NIDCD NIH HHS/United States
GR  - F30DC011673/DC/NIDCD NIH HHS/United States
GR  - F30 DC011673/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140601
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Steroids)
RN  - EC 2.7.11.12 (Cyclic GMP-Dependent Protein Kinase Type II)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Brain Mapping
MH  - Calcium Signaling
MH  - Cyclic GMP-Dependent Protein Kinase Type II/genetics
MH  - Female
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neuroimaging
MH  - Odorants
MH  - Olfactory Bulb/anatomy & histology/*physiology
MH  - Olfactory Pathways/physiology
MH  - Sex Characteristics
MH  - Smell/genetics/physiology
MH  - Steroids/pharmacology
MH  - Stimulation, Chemical
MH  - Urine/chemistry
PMC - PMC4327767
MID - NIHMS594171
COIS- The authors report no conflicts of interest.
EDAT- 2014/06/02 06:00
MHDA- 2014/08/26 06:00
PMCR- 2015/02/13
CRDT- 2014/06/02 06:00
PHST- 2014/02/28 00:00 [received]
PHST- 2014/05/05 00:00 [accepted]
PHST- 2014/06/02 06:00 [entrez]
PHST- 2014/06/02 06:00 [pubmed]
PHST- 2014/08/26 06:00 [medline]
PHST- 2015/02/13 00:00 [pmc-release]
AID - nn.3738 [pii]
AID - 10.1038/nn.3738 [doi]
PST - ppublish
SO  - Nat Neurosci. 2014 Jul;17(7):953-61. doi: 10.1038/nn.3738. Epub 2014 Jun 1.