PMID- 24880538 OWN - NLM STAT- MEDLINE DCOM- 20150309 LR - 20220316 IS - 1878-5883 (Electronic) IS - 0022-510X (Linking) VI - 343 IP - 1-2 DP - 2014 Aug 15 TI - The safety of exercise training in multiple sclerosis: a systematic review. PG - 3-7 LID - S0022-510X(14)00306-2 [pii] LID - 10.1016/j.jns.2014.05.016 [doi] AB - There are many reviews documenting the benefits of exercise training among persons with multiple sclerosis (MS). To date, we are unaware of a review that summarizes the risks of relapse and other adverse events (AEs) associated with exercise training, yet this is critical for informing decisions and recommendations regarding the safety of this behavior. We conducted a systematic review of relapse and other AEs reported in randomized controlled trials (RCTs) of exercise training in MS. We searched electronic databases for RCTs of exercise training in MS. We calculated the rate of relapse and AEs, and the relative risk of relapse and AEs for exercise training versus control. Twenty-six studies were reviewed that included 1295 participants. We determined that the rate of relapse was 6.3% and 4.6% for control and exercise, respectively. The rate of AEs was 1.2% and 2.0% for control and exercise, respectively. The relative risk of relapse for exercise training was 0.73, whereas the relative risk of AE for exercise training was 1.67. Exercise training was not associated with an increased risk of relapse, and risk of AEs was not higher than in healthy populations. This evidence should alleviate uncertainty regarding the safety of exercise training in MS. CI - Copyright (c) 2014 Elsevier B.V. All rights reserved. FAU - Pilutti, Lara A AU - Pilutti LA AD - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, USA. Electronic address: lpilutti@illinois.edu. FAU - Platta, Matthew E AU - Platta ME AD - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, USA. FAU - Motl, Robert W AU - Motl RW AD - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, USA. FAU - Latimer-Cheung, Amy E AU - Latimer-Cheung AE AD - School of Kinesiology and Health Studies, Queen's University, Kingston, Canada. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20140515 PL - Netherlands TA - J Neurol Sci JT - Journal of the neurological sciences JID - 0375403 SB - IM MH - Exercise Therapy/*methods MH - Humans MH - Multiple Sclerosis/*rehabilitation OTO - NOTNLM OT - Adverse event OT - Dropout OT - Exercise training OT - Relapse OT - Safety OT - Systematic review EDAT- 2014/06/02 06:00 MHDA- 2015/03/10 06:00 CRDT- 2014/06/02 06:00 PHST- 2013/12/23 00:00 [received] PHST- 2014/04/07 00:00 [revised] PHST- 2014/05/07 00:00 [accepted] PHST- 2014/06/02 06:00 [entrez] PHST- 2014/06/02 06:00 [pubmed] PHST- 2015/03/10 06:00 [medline] AID - S0022-510X(14)00306-2 [pii] AID - 10.1016/j.jns.2014.05.016 [doi] PST - ppublish SO - J Neurol Sci. 2014 Aug 15;343(1-2):3-7. doi: 10.1016/j.jns.2014.05.016. Epub 2014 May 15.