PMID- 24881518
OWN - NLM
STAT- MEDLINE
DCOM- 20140902
LR  - 20140712
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 109
IP  - 1
DP  - 2014 Jul 25
TI  - Oral administration of D-aspartate, but not L-aspartate, depresses rectal 
      temperature and alters plasma metabolites in chicks.
PG  - 65-71
LID - S0024-3205(14)00514-1 [pii]
LID - 10.1016/j.lfs.2014.05.015 [doi]
AB  - AIMS: L-Aspartate (L-Asp) and D-aspartate (D-Asp) are physiologically important 
      amino acids in mammals and birds. However, the functions of these amino acids 
      have not yet been fully understood. In this study, we therefore examined the 
      effects of L-Asp and D-Asp in terms of regulating body temperature, plasma 
      metabolites and catecholamines in chicks. MAIN METHODS: Chicks were first orally 
      administered with different doses (0, 3.75, 7.5 and 15 mmol/kg body weight) of L- 
      or D-Asp to monitor the effects of these amino acids on rectal temperature during 
      120 min of the experimental period. KEY FINDINGS: Oral administration of D-Asp, 
      but not of L-Asp, linearly decreased the rectal temperature in chicks. 
      Importantly, orally administered D-Asp led to a significant reduction in body 
      temperature in chicks even under high ambient temperature (HT) conditions. 
      However, centrally administered D-Asp did not significantly influence the body 
      temperature in chicks. As for plasma metabolites and catecholamines, orally 
      administered D-Asp led to decreased triacylglycerol and uric acid concentrations 
      and increased glucose and chlorine concentrations but did not alter plasma 
      catecholamines. SIGNIFICANCE: These results suggest that oral administration of 
      D-Asp may play a potent role in reducing body temperature under both normal and 
      HT conditions. The alteration of plasma metabolites further indicates that D-Asp 
      may contribute to the regulation of metabolic activity in chicks.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Erwan, Edi
AU  - Erwan E
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Chowdhury, Vishwajit Sur
AU  - Chowdhury VS
AD  - Division for Arts and Science, Faculty of Arts and Science, Kyushu University, 
      Fukuoka 819-0395, Japan.
FAU - Nagasawa, Mao
AU  - Nagasawa M
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Goda, Ryosei
AU  - Goda R
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Otsuka, Tsuyoshi
AU  - Otsuka T
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Yasuo, Shinobu
AU  - Yasuo S
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Furuse, Mitsuhiro
AU  - Furuse M
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan. Electronic address: furuse@brs.kyushu-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140529
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Blood Glucose)
RN  - 0 (Catecholamines)
RN  - 0 (Triglycerides)
RN  - 268B43MJ25 (Uric Acid)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 4SR0Q8YD1X (D-Aspartic Acid)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Aspartic Acid/administration & dosage/*pharmacology
MH  - Blood Glucose/analysis/metabolism
MH  - Body Temperature/*drug effects
MH  - Catecholamines/blood/metabolism
MH  - Chickens/blood/*physiology
MH  - D-Aspartic Acid/administration & dosage/*pharmacology
MH  - Plasma/drug effects/*metabolism
MH  - Triglycerides/blood/metabolism
MH  - Uric Acid/blood/metabolism
OTO - NOTNLM
OT  - Body temperature
OT  - Chicks
OT  - D-Aspartate
OT  - L-Aspartate
OT  - Plasma metabolites
EDAT- 2014/06/03 06:00
MHDA- 2014/09/03 06:00
CRDT- 2014/06/03 06:00
PHST- 2013/10/23 00:00 [received]
PHST- 2014/05/14 00:00 [revised]
PHST- 2014/05/19 00:00 [accepted]
PHST- 2014/06/03 06:00 [entrez]
PHST- 2014/06/03 06:00 [pubmed]
PHST- 2014/09/03 06:00 [medline]
AID - S0024-3205(14)00514-1 [pii]
AID - 10.1016/j.lfs.2014.05.015 [doi]
PST - ppublish
SO  - Life Sci. 2014 Jul 25;109(1):65-71. doi: 10.1016/j.lfs.2014.05.015. Epub 2014 May 
      29.