PMID- 24882173
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20220317
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 165
DP  - 2014 Aug
TI  - The effect of exercise on hippocampal volume and neurotrophines in patients with 
      major depression--a randomized clinical trial.
PG  - 24-30
LID - S0165-0327(14)00235-3 [pii]
LID - 10.1016/j.jad.2014.04.041 [doi]
AB  - BACKGROUND: The hippocampal volume is reduced in patients with major depression. 
      Exercise leads to an increased hippocampal volume in schizophrenia and in healthy 
      old adults. The effect of exercise on hippocampal volume is potentially mediated 
      by brain derived neurotrophic factor (BDNF), vascular endothelial growth factor 
      (VEGF), and insulin like growth factor 1 (IGF-1). The aim of this trial was to 
      assess the effect of an aerobic exercise intervention on hippocampal volume and 
      serum BDNF, VEGF, and IGF-1 in patients with major depression. METHODS: Patients 
      were randomized to an aerobic exercise intervention (n=41) or a control condition 
      (n=38). Both interventions consisted of three supervised sessions per week during 
      a three months period. RESULTS: Post-intervention the increase in maximal oxygen 
      uptake was 3.90 ml/kg/min (SD 5.1) in the aerobic exercise group and 0.95 
      ml/kg/min (SD 6.2) in the control group (p=0.03). The hippocampal volume, BDNF, 
      VEGF, or IGF-1 did not differ between the two groups. Post-hoc we found a 
      positive association between change in hippocampal volume and verbal memory 
      (Rho=0.27; p=0.05) and change in hippocampal volume and depressive symptoms 
      (Rho=0.30; p=0.03). LIMITATIONS: Participation was low in both groups 
      corresponding to an average participation of one session per week. CONCLUSION: 
      Despite a significant increase in maximal oxygen uptake, a pragmatic exercise 
      intervention did not increase hippocampal volume or resting levels of 
      neurotrophines in out-patients with mild to moderate major depression. Trial 
      identifier: ClinicalTrials.gov (NCT00695552).
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Krogh, Jesper
AU  - Krogh J
AD  - Mental Health Centre Copenhagen, Mental Health Services in the Capital Region of 
      Denmark, University of Copenhagen, Copenhagen, Denmark. Electronic address: 
      Jesper.krogh@regionh.dk.
FAU - Rostrup, Egill
AU  - Rostrup E
AD  - Functional Imaging Unit, Department of Diagnostics, Copenhagen University 
      Hospital, Glostrup Hospital, Denmark.
FAU - Thomsen, Carsten
AU  - Thomsen C
AD  - Department of Radiology, Rigshospitalet, Faculty of Health Sciences, University 
      of Copenhagen, Copenhagen, Denmark.
FAU - Elfving, Betina
AU  - Elfving B
AD  - Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus 
      University, Aarhus, Denmark.
FAU - Videbech, Poul
AU  - Videbech P
AD  - Department for Depression and Anxiety Q, Aarhus University Hospital, Risskov, 
      Denmark.
FAU - Nordentoft, Merete
AU  - Nordentoft M
AD  - Mental Health Centre Copenhagen, Mental Health Services in the Capital Region of 
      Denmark, University of Copenhagen, Copenhagen, Denmark.
LA  - eng
SI  - ClinicalTrials.gov/NCT00695552
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20140423
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/blood/*pathology
MH  - *Exercise
MH  - Female
MH  - Hippocampus/*pathology
MH  - Humans
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Memory
MH  - Middle Aged
MH  - Vascular Endothelial Growth Factor A/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - Depression
OT  - Exercise
OT  - Hippocampus
OT  - Memory
OT  - Neurogenesis
EDAT- 2014/06/03 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/06/03 06:00
PHST- 2014/01/04 00:00 [received]
PHST- 2014/04/15 00:00 [revised]
PHST- 2014/04/15 00:00 [accepted]
PHST- 2014/06/03 06:00 [entrez]
PHST- 2014/06/03 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0165-0327(14)00235-3 [pii]
AID - 10.1016/j.jad.2014.04.041 [doi]
PST - ppublish
SO  - J Affect Disord. 2014 Aug;165:24-30. doi: 10.1016/j.jad.2014.04.041. Epub 2014 
      Apr 23.