PMID- 24882899
OWN - NLM
STAT- MEDLINE
DCOM- 20141223
LR  - 20211021
IS  - 1550-9109 (Electronic)
IS  - 0161-8105 (Print)
IS  - 0161-8105 (Linking)
VI  - 37
IP  - 6
DP  - 2014 Jun 1
TI  - Narcolepsy and predictors of positive MSLTs in the Wisconsin Sleep Cohort.
PG  - 1043-51
LID - 10.5665/sleep.3758 [doi]
AB  - STUDY OBJECTIVES: To study whether positive multiple sleep latency tests (MSLTs, 
      mean sleep latency [MSL] </= 8 minutes, >/= 2 sleep onset REM sleep periods 
      [SOREMPs]) and/or nocturnal SOREMP (REM sleep latency </= 15 minutes during 
      nocturnal polysomonography [NPSG]) are stable traits and can reflect incipient 
      narcolepsy. DESIGN AND SETTING: Cross-sectional and longitudinal investigation of 
      the Wisconsin Sleep Cohort Study. PARTICIPANTS: Adults (44% females, 30-81 years) 
      underwent NPSG (n = 4,866 in 1,518 subjects), and clinical MSLT (n = 1,135), with 
      823 having a repeat NPSG-MSLT at 4-year intervals, totaling 1725 NPSG with MSLT 
      studies. Data were analyzed using linear mixed-effects models, and the stability 
      of positive MSLTs was explored using kappa statistics. MEASUREMENTS AND RESULTS: 
      Prevalence of a nocturnal SOREMP on a NPSG, of >/= 2 SOREMPs on the MSLT, of MSL </= 
      8 minutes on the MSLT, and of a positive MSLT (MSL </= 8 minutes plus >/= 2 SOREMPs) 
      were 0.35%, 7.0%, 22%, and 3.4%, respectively. Correlates of a positive MSLT were 
      shift work (OR = 7.8, P = 0.0001) and short sleep (OR = 1.51/h, P = 0.04). 
      Test-retest for these parameters was poor, with kappa < 0.2 (n.s.) after excluding 
      shift workers and short sleepers. Excluding shift-work, short sleep, and subjects 
      with negative MSLTs, we found one undiagnosed subject with possible cataplexy (>/= 
      1/month) and a NPSG SOREMPs; one subject previously diagnosed with narcolepsy 
      without cataplexy with 2 NPSG SOREMPs and a positive MSLT, and two subjects with 
      2 independently positive MSLTs (66% human leukocyte antigen [HLA] positive). The 
      proportions for narcolepsy with and without cataplexy were 0.07% (95% CI: 
      0.02-0.37%) and 0.20% (95% CI: 0.07-0.58%), respectively. CONCLUSIONS: The 
      diagnostic value of multiple sleep latency tests is strongly altered by shift 
      work and to a lesser extent by chronic sleep deprivation. The prevalence of 
      narcolepsy without cataplexy may be 3-fold higher than that of 
      narcolepsy-cataplexy.
FAU - Goldbart, Aviv
AU  - Goldbart A
AD  - Department of Pediatrics and Sleep Wake Disorders Unit, Faculty of Health 
      Sciences, Ben Gurion University, Soroka University Medical Center, Beer Sheva, 
      Israel ; Center for Sleep Sciences and Medicine, and Department of Psychiatry and 
      Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA.
FAU - Peppard, Paul
AU  - Peppard P
AD  - Department of Population Health Sciences, University of Wisconsin-Madison, 
      Madison, WI.
FAU - Finn, Laurel
AU  - Finn L
AD  - Department of Population Health Sciences, University of Wisconsin-Madison, 
      Madison, WI.
FAU - Ruoff, Chad M
AU  - Ruoff CM
AD  - Center for Sleep Sciences and Medicine, and Department of Psychiatry and 
      Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA.
FAU - Barnet, Jodi
AU  - Barnet J
AD  - Department of Pediatrics and Sleep Wake Disorders Unit, Faculty of Health 
      Sciences, Ben Gurion University, Soroka University Medical Center, Beer Sheva, 
      Israel.
FAU - Young, Terry
AU  - Young T
AD  - Department of Population Health Sciences, University of Wisconsin-Madison, 
      Madison, WI.
FAU - Mignot, Emmanuel
AU  - Mignot E
AD  - Center for Sleep Sciences and Medicine, and Department of Psychiatry and 
      Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA.
LA  - eng
GR  - UL1 TR000427/TR/NCATS NIH HHS/United States
GR  - NS23724/NS/NINDS NIH HHS/United States
GR  - R01HL62252/HL/NHLBI NIH HHS/United States
GR  - UL1RR025011/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140601
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
SB  - IM
CIN - Sleep. 2014 Jun;37(6):1027-8. PMID: 24882894
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cataplexy/diagnosis/physiopathology
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Narcolepsy/*diagnosis/*physiopathology
MH  - Polysomnography
MH  - Prevalence
MH  - Sleep Deprivation
MH  - Sleep Disorders, Circadian Rhythm
MH  - Sleep, REM/*physiology
MH  - Time Factors
MH  - Wisconsin
PMC - PMC4015378
OTO - NOTNLM
OT  - HLA
OT  - MSLT
OT  - REM sleep
OT  - cataplexy
OT  - narcolepsy
OT  - polysomnography
EDAT- 2014/06/03 06:00
MHDA- 2014/12/24 06:00
PMCR- 2014/12/01
CRDT- 2014/06/03 06:00
PHST- 2014/06/03 06:00 [entrez]
PHST- 2014/06/03 06:00 [pubmed]
PHST- 2014/12/24 06:00 [medline]
PHST- 2014/12/01 00:00 [pmc-release]
AID - 10.5665/sleep.3758 [doi]
PST - epublish
SO  - Sleep. 2014 Jun 1;37(6):1043-51. doi: 10.5665/sleep.3758.