PMID- 24882966
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140602
LR  - 20211021
IS  - 1013-9087 (Print)
IS  - 2005-3894 (Electronic)
IS  - 1013-9087 (Linking)
VI  - 26
IP  - 2
DP  - 2014 Apr
TI  - Correlations between Anti-Mast Cell Autoantibodies and Chronic Idiopathic 
      Urticaria.
PG  - 145-9
LID - 10.5021/ad.2014.26.2.145 [doi]
AB  - BACKGROUND: The etiology of chronic idiopathic urticaria (CIU) is not completely 
      clear. There are a few antibodies were reported to correlate with CIU. OBJECTIVE: 
      To investigate the correlation these antibodies and CIU. METHODS: The autologous 
      serum skin test (ASST) and allergens were performed. Serum levels of 
      immunoglobulin E (IgE), anti-FcepsilonRI and anti-IgE, anti-Helicobacter pylori (HP) 
      antibodies and anti-thyroglobulin antibody (TGAb) were measured in 100 patients 
      with CIU, acute urticaria (AU) and normal controls respectively. RESULTS: 
      Eighty-six percent food or inhalant allergens were detected in AU patients, but 
      no allergens were detected in CIU patients and normal controls. Serum anti-FcepsilonRI 
      antibody and anti-IgE antibody levels were higher in the CIU than that in the AU 
      patients and normal controls (p<0.05, respectively). IgE level was lower in the 
      CIU patients (T=190.00, p< 0.05), but increased in the AU patients (T=226.00, 
      p<0.05) compared with the normal controls. The ASST positive rates in the CIU and 
      the AU patients were 53.4% and 12.6% respectively, but all normal controls were 
      negative. The anti-FcepsilonRI antibody level was higher in the ASST-positive CIU 
      patients than those negative ones (T=101.73, p<0.05). In anti-HP antibody 
      positive and TGAb positive CIU patients, anti-FcepsilonRI antibody positive rate was 
      higher than AU patients (p<0.01) and normal controls (p<0.01). CONCLUSION: The 
      anti-FcepsilonRI and anti-IgE antibodies play a key role in CIU, but anti-HP antibody 
      and TGAb have an indirect correlation with CIU.
FAU - Sun, Liwei
AU  - Sun L
AD  - Department of Dermatology, Yantai Yuhuangding Hospital of Qingdao University 
      Medical College, Yantai, China.
FAU - Erxun, Kang
AU  - Erxun K
AD  - Department of Dermatology, Yantai Yuhuangding Hospital of Qingdao University 
      Medical College, Yantai, China.
FAU - Li, Jie
AU  - Li J
AD  - Department of Clinical Laboratory, Yantai Yuhuangding Hospital of Qingdao 
      University Medical College, Yantai, China.
FAU - Yang, Jian
AU  - Yang J
AD  - Blood Center in Yantai, Yantai, China.
FAU - Han, Chunyu
AU  - Han C
AD  - Department of Dermatology, Yantai Yuhuangding Hospital of Qingdao University 
      Medical College, Yantai, China.
LA  - eng
PT  - Journal Article
DEP - 20140430
PL  - Korea (South)
TA  - Ann Dermatol
JT  - Annals of dermatology
JID - 8916577
PMC - PMC4037664
OTO - NOTNLM
OT  - Anti-Helicobacter pylori antibody
OT  - Anti-immunoglobulin E antibody
OT  - Anti-thyroglobulin
OT  - Antibody
OT  - Chronic idiopathic urticaria
EDAT- 2014/06/03 06:00
MHDA- 2014/06/03 06:01
PMCR- 2014/04/01
CRDT- 2014/06/03 06:00
PHST- 2012/06/20 00:00 [received]
PHST- 2012/10/06 00:00 [revised]
PHST- 2013/01/28 00:00 [accepted]
PHST- 2014/06/03 06:00 [entrez]
PHST- 2014/06/03 06:00 [pubmed]
PHST- 2014/06/03 06:01 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - 10.5021/ad.2014.26.2.145 [doi]
PST - ppublish
SO  - Ann Dermatol. 2014 Apr;26(2):145-9. doi: 10.5021/ad.2014.26.2.145. Epub 2014 Apr 
      30.