PMID- 24885616
OWN - NLM
STAT- MEDLINE
DCOM- 20150327
LR  - 20231031
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 9
DP  - 2014 May 12
TI  - Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus 
      patients: a systemic review and meta-analysis.
PG  - 91
LID - 10.1186/1746-1596-9-91 [doi]
AB  - BACKGROUND: Insulin is widely used in patients with type 2 diabetes mellitus 
      (T2DM). More attention was focused on its higher risk of colorectal cancer (CRC). 
      This meta-analysis examined the relationship between levels of insulin use and 
      the risk of CRC. METHODS: A meta-analysis using data from 12 published 
      epidemiologic studies (7 case-control, and 5 cohort studies) published before 
      Jan. 2014 was done to examine the association between insulin use and CRC. Random 
      effects analyses were done to calculate relative risk (RR) and 95% confidence 
      intervals (CI). Heterogeneity among studies was measured by the chi2 and I2 
      statistic. RESULTS: Overall, the risk of CRC was significantly associated with 
      insulin use to a random-effects model (RR, 1.69; 95% CI, 1.25 -2.27). When 
      subgroup analyses were conducted according to the study types, no associations 
      were detected in cohort group (RR, 1.25; 95% CI, 0.95-1.65; I2, 75.7%); however 
      significant association was detected in case-control group (RR, 2.15; 95% CI, 
      1.41-3.26; I2, 89.1%). CONCLUSIONS: A significant harmful effect of insulin, 
      observed mainly among case-control studies, may result from study design 
      differences and amount of included studies. Although these results suggest a 
      harmful effect of insulin use for CRC risk, additional large studies are 
      warranted to support these preliminary evidences. VIRTUAL SLIDES: The virtual 
      slide(s) for this article can be found here: 
      http://www.diagnosticpathology.diagnomx.eu/vs/2194715731194123.
FAU - Yin, Shinan
AU  - Yin S
AD  - Department of Endocrinology, First affiliated hospital of General hospital of 
      PLA, Beijing 100048, China. yinshinan2011@163.com.
FAU - Bai, Hua
AU  - Bai H
FAU - Jing, Danqing
AU  - Jing D
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20140512
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Colorectal Neoplasms/*epidemiology
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Humans
MH  - Hypoglycemic Agents/*adverse effects
MH  - Insulin/*adverse effects
PMC - PMC4107999
EDAT- 2014/06/03 06:00
MHDA- 2015/04/02 06:00
PMCR- 2014/05/12
CRDT- 2014/06/03 06:00
PHST- 2014/01/23 00:00 [received]
PHST- 2014/04/02 00:00 [accepted]
PHST- 2014/06/03 06:00 [entrez]
PHST- 2014/06/03 06:00 [pubmed]
PHST- 2015/04/02 06:00 [medline]
PHST- 2014/05/12 00:00 [pmc-release]
AID - 1746-1596-9-91 [pii]
AID - 10.1186/1746-1596-9-91 [doi]
PST - epublish
SO  - Diagn Pathol. 2014 May 12;9:91. doi: 10.1186/1746-1596-9-91.