PMID- 24886430
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20220318
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 12
DP  - 2014 May 5
TI  - Estimating a minimal clinically important difference for the EuroQol 5-Dimension 
      health status index in persons with multiple sclerosis.
PG  - 66
LID - 10.1186/1477-7525-12-66 [doi]
AB  - BACKGROUND: Limited data define what constitutes a minimal clinically important 
      difference (MCID) on the EuroQol 5-Dimension (EQ-5D) health status index in 
      persons with multiple sclerosis (PwMS). We sought to estimate the MCID for the 
      EQ-5D health index in North American PwMS. METHODS: PwMS completing the Patient 
      Determined Disease Steps (PDDS) scale, 12-Item Multiple Sclerosis Walking Scale 
      (MSWS-12) and EQ-5D as part of the North American Research Committee on Multiple 
      Sclerosis (NARCOMS) registry's spring 2011 update and supplemental survey were 
      included in this retrospective, cross-sectional study. Distribution-based 
      (standard error of measurement [SEM], 0.50 standard deviation [SD] and 0.33 SD 
      unit) approaches were used to estimate a range of MCIDs for the EQ-5D based upon 
      disease severity groups determined by the PDDS and MSWS-12 tertiles. RESULTS: A 
      total of 3,044 participants were included. Moderately strong correlations between 
      the EQ-5D and the PDDS and MSWS-12 were observed (Spearman's r = -0.56 and -0.59, 
      respectively, p < 0.0001 for both). MCID estimates based on PDDS score categories 
      ranged from 0.065-0.158 (SEMs), 0.059-0.142 (0.50 SDs) and 0.039-0.095 (0.33 
      SDs). MCID estimates as measured by MSWS-12 tertile categories ranged from 
      0.068-0.098 (SEMs), 0.061-0.088 (0.50 SDs), and 0.041-0.059 (0.33 SDs). Across 
      both the PDDS and tertiles of MSWS-12, MCID estimates tended to be larger as 
      disease severity worsened. Mean weighted MCID estimates ranged from 0.05-0.084 
      for both the PDDS and MSWS-12 tertiles. CONCLUSION: MCID estimates for the EQ-5D 
      in PwMS were within the range of estimates seen for other disease states and 
      appeared to be larger in those reporting more severe disease.
FAU - Kohn, Christine G
AU  - Kohn CG
FAU - Sidovar, Matthew F
AU  - Sidovar MF
FAU - Kaur, Kirandeep
AU  - Kaur K
FAU - Zhu, Yungfen
AU  - Zhu Y
FAU - Coleman, Craig I
AU  - Coleman CI
AD  - Department of Pharmacy Practice, University of Connecticut School of Pharmacy, 
      Storrs, CT, USA. craig.coleman@hhchealth.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140505
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - Cross-Sectional Studies
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*diagnosis
MH  - *Quality of Life
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
PMC - PMC4018196
EDAT- 2014/06/03 06:00
MHDA- 2014/09/30 06:00
PMCR- 2014/05/05
CRDT- 2014/06/03 06:00
PHST- 2013/12/06 00:00 [received]
PHST- 2014/04/30 00:00 [accepted]
PHST- 2014/06/03 06:00 [entrez]
PHST- 2014/06/03 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
PHST- 2014/05/05 00:00 [pmc-release]
AID - 1477-7525-12-66 [pii]
AID - 10.1186/1477-7525-12-66 [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2014 May 5;12:66. doi: 10.1186/1477-7525-12-66.