PMID- 24887566
OWN - NLM
STAT- MEDLINE
DCOM- 20140921
LR  - 20211203
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 450
IP  - 1
DP  - 2014 Jul 18
TI  - Mollugin induces tumor cell apoptosis and autophagy via the PI3K/AKT/mTOR/p70S6K 
      and ERK signaling pathways.
PG  - 247-54
LID - S0006-291X(14)00990-5 [pii]
LID - 10.1016/j.bbrc.2014.05.101 [doi]
AB  - Mollugin, a bioactive phytochemical isolated from Rubia cordifolia L., has shown 
      preclinical anticancer efficacy in various cancer models. However the effects of 
      mollugin in regulating cancer cell survival and death remains undefined. In the 
      present study we found that mollugin exhibited cytotoxicity on various cancer 
      models. The suppression of cell viability was due to the induction of 
      mitochondria apoptosis. In addition, the presence of autophagic hallmarks was 
      observed in mollugin-treated cells. Notably, blockade of autophagy by a chemical 
      inhibitor or RNA interference enhanced the cytotoxicity of mollugin. Further 
      experiments demonstrated that phosphatidylinositide 3-kinases/protein kinase 
      B/mammalian target of rapamycin/p70S6 kinase (PI3K/AKT/mTOR/p70S6K) and 
      extracellular regulated protein kinases (ERK) signaling pathways participated in 
      mollugin-induced autophagy and apoptosis. Together, these findings support 
      further studies of mollugin as candidate for treatment of human cancer cells.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, Jiangsu Province, China.
FAU - Wang, Handong
AU  - Wang H
AD  - Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, Jiangsu Province, China. Electronic address: 
      njhdwang@hotmail.com.
FAU - Zhu, Jianhong
AU  - Zhu J
AD  - Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, Jiangsu Province, China.
FAU - Xu, Jianguo
AU  - Xu J
AD  - Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, Jiangsu Province, China.
FAU - Ding, Ke
AU  - Ding K
AD  - Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, Jiangsu Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140602
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Pyrans)
RN  - 55481-88-4 (rubimaillin)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cell Death/*drug effects
MH  - Cell Line, Tumor
MH  - Dose-Response Relationship, Drug
MH  - Drugs, Chinese Herbal/administration & dosage
MH  - Humans
MH  - MAP Kinase Signaling System/drug effects
MH  - Mice
MH  - Neoplasms, Experimental/*metabolism/pathology
MH  - Phosphatidylinositol 3-Kinases/*metabolism
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - Pyrans/*administration & dosage
MH  - Ribosomal Protein S6 Kinases, 70-kDa/*metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - Apoptosis
OT  - Autophagy
OT  - ERK
OT  - Mollugin
OT  - PI3K/AKT/mTOR/p70S6K
EDAT- 2014/06/03 06:00
MHDA- 2014/09/23 06:00
CRDT- 2014/06/03 06:00
PHST- 2014/05/08 00:00 [received]
PHST- 2014/05/22 00:00 [accepted]
PHST- 2014/06/03 06:00 [entrez]
PHST- 2014/06/03 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
AID - S0006-291X(14)00990-5 [pii]
AID - 10.1016/j.bbrc.2014.05.101 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2014 Jul 18;450(1):247-54. doi: 
      10.1016/j.bbrc.2014.05.101. Epub 2014 Jun 2.