PMID- 24888254
OWN - NLM
STAT- MEDLINE
DCOM- 20160125
LR  - 20221207
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 16
IP  - 3
DP  - 2015 May
TI  - Impact of regular physical activity on blood glucose control and cardiovascular 
      risk factors in adolescents with type 2 diabetes mellitus--a multicenter study of 
      578 patients from 225 centres.
PG  - 204-10
LID - 10.1111/pedi.12144 [doi]
AB  - INTRODUCTION: Regular physical activity (RPA) is a major therapeutic 
      recommendation in children and adolescents with type 2 diabetes mellitus (T2DM). 
      We evaluated the association between frequency of RPA and metabolic control, 
      cardiovascular risk factors, and treatment regimes. METHODS: The Pediatric 
      Quality Initiative (DPV), including data from 225 centers in Germany and Austria, 
      provided anonymous data of 578 patients (10-20 yr; mean 15.7 +/- 2.1 yr; 61.9% 
      girls) with T2DM. Patients were grouped by the frequency of their self-reported 
      RPA per week: RPA 0, none; RPA 1, 1-2x/wk; RPA 2, >2x/wk. RESULTS: The frequency 
      of RPA ranged from 0 to 9x/wk (mean 1.1x/wk +/-1.5). 55.7% of the patients reported 
      no RPA (58.1% of the girls). Hemoglobin A1c (HbA1c) differed significantly among 
      RPA groups (p < 0.002), being approximately 0.8 percentage points lower in RPA 2 
      compared to RPA 0. Body mass index (BMI-SDS) was higher in the groups with less 
      frequent RPA (p < 0.00001). Multiple regression analysis revealed a negative 
      association between RPA and HbA1c (p < 0.0001) and between RPA and BMI-SDS (p < 
      0.01). The association between RPA and high density lipoprotein (HDL)-cholesterol 
      was positive (p < 0.05), while there was no association to total cholesterol, low 
      density lipoprotein (LDL)-cholesterol or triglycerides. Approximately 80% of the 
      patients received pharmacological treatment (oral antidiabetic drugs and/or 
      insulin) without differences between RPA groups. CONCLUSION: More than half of 
      the adolescents with T2DM did not perform RPA. Increasing physical activity was 
      associated with a lower HbA1c, a lower BMI-SDS, a higher HDL-cholesterol, but not 
      with a difference in treatment regime. These results suggest that regular 
      exercise is a justified therapeutic recommendation for children and adolescents 
      with T2DM.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Herbst, A
AU  - Herbst A
AD  - Department of Pediatrics, Hospital of Leverkusen, Leverkusen 51375, Germany.
FAU - Kapellen, T
AU  - Kapellen T
FAU - Schober, E
AU  - Schober E
FAU - Graf, C
AU  - Graf C
FAU - Meissner, T
AU  - Meissner T
FAU - Holl, R W
AU  - Holl RW
CN  - DPV-Science-Initiative
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140602
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Lipids)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adolescent
MH  - *Blood Glucose
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Child
MH  - Diabetes Mellitus, Type 2/*blood/drug therapy
MH  - Exercise/*physiology
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Lipids/blood
MH  - Male
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - adolescents
OT  - body weight
OT  - cardiovascular risk factors
OT  - children
OT  - exercise
OT  - type 2 diabetes mellitus
EDAT- 2014/06/04 06:00
MHDA- 2016/01/26 06:00
CRDT- 2014/06/04 06:00
PHST- 2013/09/15 00:00 [received]
PHST- 2014/03/06 00:00 [revised]
PHST- 2014/03/06 00:00 [accepted]
PHST- 2014/06/04 06:00 [entrez]
PHST- 2014/06/04 06:00 [pubmed]
PHST- 2016/01/26 06:00 [medline]
AID - 10.1111/pedi.12144 [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2015 May;16(3):204-10. doi: 10.1111/pedi.12144. Epub 2014 Jun 
      2.