PMID- 24892430
OWN - NLM
STAT- MEDLINE
DCOM- 20150730
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 6
DP  - 2014
TI  - Suboptimal vitamin D status in a population-based study of Asian children: 
      prevalence and relation to allergic diseases and atopy.
PG  - e99105
LID - 10.1371/journal.pone.0099105 [doi]
LID - e99105
AB  - BACKGROUND: New evidence shows high prevalence of vitamin D deficiency in many 
      countries and some studies suggest a possible link between vitamin D status and 
      allergic diseases. The objectives of this study were to determine the prevalence 
      of suboptimal vitamin D status in a population sample of Asian children and to 
      investigate the relationship of vitamin D status with allergic diseases and 
      atopy. METHODS: Children aged 5-18 years (N = 1315) in the Prediction of 
      Allergies in Taiwanese CHildren (PATCH) study were evaluated using 
      questionnaires, anthropometric measurements, and serum levels of 
      25-hydroxyvitamin D [25(OH)D] and total and specific immunoglobulin E (IgE). 
      RESULTS: The mean concentration of serum 25(OH)D was 20.4 ng/mL (SD: 7.1 ng/mL). 
      Vitamin D deficiency (defined as serum 25(OH)D<20 ng/mL) was present in 670 
      subjects (51.0%), while vitamin D insufficiency (defined as serum 25(OH)D<30 
      ng/mL) was observed in 1187 subjects (90.3%). Older age (P<0.001), female gender 
      (P<0.001), higher body mass index (P = 0.001), winter and spring seasons 
      (compared to summer; P both<0.001), and passive smoking (P = 0.011) were 
      independently associated with low serum 25(OH)D levels. After adjusting for 
      potential confounders, serum 25(OH)D status had no association with asthma, 
      rhinitis, eczema, atopy, or total serum IgE (all P>0.05). CONCLUSIONS: Low serum 
      25(OH)D levels are remarkably common in this population sample of Asian children, 
      suggesting that millions of children living in Taiwan may have suboptimal levels 
      of vitamin D, which should be a matter of public health concern. Our results 
      provides epidemiological evidence against the association of vitamin D status 
      with various allergic diseases and atopy in Asian children.
FAU - Yao, Tsung-Chieh
AU  - Yao TC
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, 
      Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at 
      Keelung, Keelung, Taiwan.
FAU - Tu, Yu-Ling
AU  - Tu YL
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, 
      Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at 
      Keelung, Keelung, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang 
      Gung University College of Medicine, Taoyuan, Taiwan.
FAU - Chang, Su-Wei
AU  - Chang SW
AD  - Clinical Informatics and Medical Statistics Research Center, Chang Gung 
      University College of Medicine, Taoyuan, Taiwan.
FAU - Tsai, Hui-Ju
AU  - Tsai HJ
AD  - Division of Biostatistics and Bioinformatics, Institutes of Population Health 
      Sciences, National Health Research Institutes, Miaoli, Taiwan; Department of 
      Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, 
      Illinois, United States of America; Department of Genome Medicine, Kaohsiung 
      University, Kaohsiung, Taiwan.
FAU - Gu, Po-Wen
AU  - Gu PW
AD  - Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
FAU - Ning, Hsian-Chen
AU  - Ning HC
AD  - Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
FAU - Hua, Man-Chin
AU  - Hua MC
AD  - Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, 
      Keelung, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at 
      Keelung, Keelung, Taiwan.
FAU - Liao, Sui-Ling
AU  - Liao SL
AD  - Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, 
      Keelung, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at 
      Keelung, Keelung, Taiwan.
FAU - Tsai, Ming-Han
AU  - Tsai MH
AD  - Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, 
      Keelung, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at 
      Keelung, Keelung, Taiwan.
FAU - Chiu, Chih-Yung
AU  - Chiu CY
AD  - Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, 
      Keelung, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at 
      Keelung, Keelung, Taiwan.
FAU - Lai, Shen-Hao
AU  - Lai SH
AD  - Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, 
      Keelung, Taiwan; Division of Pediatric Pulmonology, Department of Pediatrics, 
      Chang Gung Memorial Hospital, Taoyuan, Taiwan.
FAU - Yeh, Kuo-Wei
AU  - Yeh KW
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, 
      Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at 
      Keelung, Keelung, Taiwan.
FAU - Huang, Jing-Long
AU  - Huang JL
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, 
      Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at 
      Keelung, Keelung, Taiwan.
CN  - PATCH study group
FAU - Huang, Jing-Long
AU  - Huang JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140603
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 1406-16-2 (Vitamin D)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Adolescent
MH  - Asian People
MH  - Body Mass Index
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/diagnosis/*epidemiology
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Multivariate Analysis
MH  - Prevalence
MH  - Regression Analysis
MH  - Seasons
MH  - Smoking
MH  - Surveys and Questionnaires
MH  - Taiwan/epidemiology
MH  - Vitamin D/*analogs & derivatives/blood
MH  - Vitamin D Deficiency/epidemiology
PMC - PMC4043968
COIS- Competing Interests: The authors have declared that no competing interests exist.
FIR - Huang, Jing-Long
IR  - Huang JL
FIR - Yao, Tsung-Chieh
IR  - Yao TC
FIR - Lee, Wen-I
IR  - Lee WI
FIR - Ou, Liang-Shiou
IR  - Ou LS
FIR - Chen, Li-Chen
IR  - Chen LC
FIR - Yeh, Kuo-Wei
IR  - Yeh KW
FIR - Tu, Yu-Ling
IR  - Tu YL
FIR - Hua, Man-Chin
IR  - Hua MC
FIR - Tsai, Ming-Han
IR  - Tsai MH
FIR - Liao, Sui-Ling
IR  - Liao SL
FIR - Lai, Shen-Hao
IR  - Lai SH
EDAT- 2014/06/04 06:00
MHDA- 2015/08/01 06:00
PMCR- 2014/06/03
CRDT- 2014/06/04 06:00
PHST- 2014/01/16 00:00 [received]
PHST- 2014/05/10 00:00 [accepted]
PHST- 2014/06/04 06:00 [entrez]
PHST- 2014/06/04 06:00 [pubmed]
PHST- 2015/08/01 06:00 [medline]
PHST- 2014/06/03 00:00 [pmc-release]
AID - PONE-D-14-02247 [pii]
AID - 10.1371/journal.pone.0099105 [doi]
PST - epublish
SO  - PLoS One. 2014 Jun 3;9(6):e99105. doi: 10.1371/journal.pone.0099105. eCollection 
      2014.