PMID- 24894465
OWN - NLM
STAT- MEDLINE
DCOM- 20160329
LR  - 20211021
IS  - 2050-084X (Electronic)
IS  - 2050-084X (Linking)
VI  - 3
DP  - 2014 Jun 3
TI  - Sex-specific processing of social cues in the medial amygdala.
PG  - e02743
LID - 10.7554/eLife.02743 [doi]
LID - e02743
AB  - Animal-animal recognition within, and across species, is essential for predator 
      avoidance and social interactions. Despite its essential role in orchestrating 
      responses to animal cues, basic principles of information processing by the 
      vomeronasal system are still unknown. The medial amygdala (MeA) occupies a 
      central position in the vomeronasal pathway, upstream of hypothalamic centers 
      dedicated to defensive and social responses. We have characterized sensory 
      responses in the mouse MeA and uncovered emergent properties that shed new light 
      onto the transformation of vomeronasal information into sex- and species-specific 
      responses. In particular, we show that the MeA displays a degree of stimulus 
      selectivity and a striking sexually dimorphic sensory representation that are not 
      observed in the upstream relay of the accessory olfactory bulb (AOB). 
      Furthermore, our results demonstrate that the development of sexually dimorphic 
      circuits in the MeA requires steroid signaling near the time of puberty to 
      organize the functional representation of sensory stimuli.DOI: 
      http://dx.doi.org/10.7554/eLife.02743.001.
CI  - Copyright (c) 2014, Bergan et al.
FAU - Bergan, Joseph F
AU  - Bergan JF
AD  - Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard 
      University, Cambridge, United States.
FAU - Ben-Shaul, Yoram
AU  - Ben-Shaul Y
AD  - School of Medicine, Department of Medical Neurobiology, The Hebrew University of 
      Jerusalem, Jerusalem, Israel.
FAU - Dulac, Catherine
AU  - Dulac C
AD  - Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard 
      University, Cambridge, United States dulac@fas.harvard.edu.
LA  - eng
GR  - R01DC013087/DC/NIDCD NIH HHS/United States
GR  - R01DC009019/DC/NIDCD NIH HHS/United States
GR  - F32 DC10089/DC/NIDCD NIH HHS/United States
GR  - R01 DC013087/DC/NIDCD NIH HHS/United States
GR  - F32 DC010089/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140603
PL  - England
TA  - Elife
JT  - eLife
JID - 101579614
RN  - 0 (Hormones)
SB  - IM
MH  - Amygdala/*physiology
MH  - Animals
MH  - Cues
MH  - Female
MH  - Hormones/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neurons/metabolism
MH  - Odorants
MH  - Olfactory Bulb/physiology
MH  - Olfactory Mucosa/physiology
MH  - *Sex Factors
MH  - Sexual Behavior, Animal/physiology
MH  - Vomeronasal Organ/physiology
PMC - PMC4038839
OTO - NOTNLM
OT  - behavior
OT  - medial amygdala
OT  - pheromones
OT  - sensory representation
OT  - sexual dimorphism
OT  - vomeronasal system
COIS- CD: Senior editor, eLife. The other authors declare that no competing interests 
      exist.
EDAT- 2014/06/05 06:00
MHDA- 2014/06/05 06:01
PMCR- 2014/06/04
CRDT- 2014/06/05 06:00
PHST- 2014/06/05 06:00 [entrez]
PHST- 2014/06/05 06:00 [pubmed]
PHST- 2014/06/05 06:01 [medline]
PHST- 2014/06/04 00:00 [pmc-release]
AID - 02743 [pii]
AID - 10.7554/eLife.02743 [doi]
PST - epublish
SO  - Elife. 2014 Jun 3;3:e02743. doi: 10.7554/eLife.02743.