PMID- 24894810
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20221207
IS  - 1471-5945 (Electronic)
IS  - 1471-5945 (Linking)
VI  - 14
DP  - 2014 Jun 4
TI  - HLA class II alleles may influence susceptibility to adult dermatomyositis and 
      polymyositis in a Han Chinese population.
PG  - 9
LID - 10.1186/1471-5945-14-9 [doi]
AB  - BACKGROUND: Polymyositis (PM) and dermatomyositis (DM) are idiopathic 
      inflammatory myopathies. Genetic variability in human leukocyte antigen (HLA) 
      genes plays an important role in the pathogenesis of PM and DM. However, few 
      studies on the subject in Chinese populations have been reported thus far. 
      METHODS: We studied the influence of HLA polymorphisms on DM and PM 
      susceptibility by analyzing HLA-DRB1, HLA-DQA1, and HLA-DQB1 alleles in 71 adult 
      DM patients, 20 adult PM patients, and 113 controls in a Han Chinese population. 
      RESULTS: A positive association was found between HLA-DQA1*0104 and DM (p = 0.01; 
      corrected p (pcorr) NS; odds ratio (OR) = 2.58; 95% confidence interval (CI): 
      1.18-5.64), while an inverse correlation was noted between HLA-DQB1*0303 and 
      myositis patients with interstitial lung inflammation (p = 0.01; pcorr NS; 
      OR = 0.25; 95% CI: 0.07-0.73). A positive relationship was also observed between 
      HLA-DRB1*07 and DM (p = 0.01; pcorr NS; OR = 2.26; 95% CI: 1.12-4.59), while 
      HLA-DRB1*03 seems to be protective against DM (p = 0.01; pcorr NS; OR = 0.26; 95% 
      CI: 0.06-0.81). The lung complication was closely associated with HLA-DRB1*04 
      (p = 0.01; pcorr NS; OR = 2.82; 95% CI: 1.15-6.76) and HLA-DRB1*12 (p = 0.02; 
      pcorr NS; OR = 2.52; 95% CI: 1.02-6.07). The frequency of HLA-DRB1*07 was 
      significantly higher among myositis patients with dysphagia than among controls 
      (p = 0.01; pcorr NS; OR = 4.78; 95% CI: 1.03-24.42). The putative haplotype 
      DRB1*07-DQA1*01-DQB1*02 was positively correlated with DM (p = 0.03; pcorr NS; 
      OR = 2.90; 95% CI: 1.02-8.93) and the lung complication (p = 0.02; pcorr NS; 
      OR = 3.45; 95% CI: 1.04-11.58). CONCLUSIONS: Our results demonstrate that HLA 
      alleles may be involved in susceptibility to adult DM and PM in the Han Chinese 
      population.
FAU - Gao, Xiang
AU  - Gao X
FAU - Han, Lei
AU  - Han L
FAU - Yuan, Lan
AU  - Yuan L
FAU - Yang, Yongchen
AU  - Yang Y
FAU - Gou, Guimei
AU  - Gou G
FAU - Sun, Hengjuan
AU  - Sun H
FAU - Lu, Ling
AU  - Lu L
AD  - Departments of Rheumatology and Occupational Medicine, Huashan Hospital of Fudan 
      University, Shanghai, China. huashanlvling@sina.com.
FAU - Bao, Liming
AU  - Bao L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140604
PL  - England
TA  - BMC Dermatol
JT  - BMC dermatology
JID - 100968541
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/*genetics
MH  - Dermatomyositis/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ alpha-Chains/genetics
MH  - HLA-DQ beta-Chains/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Polymyositis/*genetics
MH  - Risk Factors
PMC - PMC4062285
EDAT- 2014/06/05 06:00
MHDA- 2015/01/06 06:00
PMCR- 2014/06/04
CRDT- 2014/06/05 06:00
PHST- 2013/11/18 00:00 [received]
PHST- 2014/05/28 00:00 [accepted]
PHST- 2014/06/05 06:00 [entrez]
PHST- 2014/06/05 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
PHST- 2014/06/04 00:00 [pmc-release]
AID - 1471-5945-14-9 [pii]
AID - 10.1186/1471-5945-14-9 [doi]
PST - epublish
SO  - BMC Dermatol. 2014 Jun 4;14:9. doi: 10.1186/1471-5945-14-9.