PMID- 24894948
OWN - NLM
STAT- MEDLINE
DCOM- 20150223
LR  - 20181202
IS  - 1568-5624 (Electronic)
IS  - 0920-5063 (Linking)
VI  - 25
IP  - 11
DP  - 2014
TI  - Preparation and investigation of high solid content PTX-loaded nanoparticles 
      dispersion via nanoprecipitation method.
PG  - 1144-58
LID - 10.1080/09205063.2014.923365 [doi]
AB  - The improvement of the solid content of the hydrophobic drugs (such as paclitaxel 
      (PTX), etc.) loaded nanoparticles (NPs) dispersion is important for enhancing 
      drug-loaded efficiency and reducing the cost in production and application. A 
      diblock copolymer methoxy poly(ethylene 
      glycol)-b-poly(epsilon-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) (mPECT) is 
      synthesized via the ring-opening polymerization of epsilon-caprolactone and 
      1,4,8-trioxa[4.6]spiro-9-undecanone (TOSUO) with methoxy poly(ethyleneglycol) 
      (mPEG） as the initiator. The chemical structures and thermal properties of mPECT 
      are characterized by (1)HNMR, Fourier transform infrared (FT-IR), gel permeation 
      chromatography, differential scanning calorimetry, etc. 
      PEG45.45-b-P(C28.33-co-T5.38) (mPECT-2) is able to self-assemble into stable NPs 
      in water via nanoprecipitation method at a high solid content (</=25 wt%) and their 
      freeze-dried powders can well re-disperse in water. The paclitaxel (PTX) is 
      chosen as a hydrophobic drug model and successfully encapsulate into the mPECT-2 
      NPs via the same method at a high solid content. The encapsulation efficiency, 
      cytotoxicity and in vitro release of PTX-loaded NPs are investigated. The results 
      suggest that the behavior of the drug-loaded mPECT-2 NPs prepared at a solid 
      content of 25 wt% is similar to that of NPs prepared at a solid content of 1 wt%, 
      which indicate that increasing solid content of polymer has no negative effect on 
      the properties of NPs dispersion in application. In summary, the freeze-dried NPs 
      prepared from the high solid content dispersion (</=25 wt%) has a good 
      redispersibility and exhibits great potential in cost control of preparing NPs 
      dispersion used as drug delivery system.
FAU - Xiang, Yuzhang
AU  - Xiang Y
AD  - a Department of Polymer Science and Technology , School of Chemical Engineering 
      and Technology, Tianjin University , Tianjin 300072 , China.
FAU - Xiao, Miao
AU  - Xiao M
FAU - Han, Shangcong
AU  - Han S
FAU - Xu, Shuxin
AU  - Xu S
FAU - Cao, Yan
AU  - Cao Y
FAU - Lv, Zesheng
AU  - Lv Z
FAU - Liu, Jianfeng
AU  - Liu J
FAU - Liu, Jinjian
AU  - Liu J
FAU - Deng, Liandong
AU  - Deng L
FAU - Dong, Anjie
AU  - Dong A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140604
PL  - England
TA  - J Biomater Sci Polym Ed
JT  - Journal of biomaterials science. Polymer edition
JID - 9007393
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Nanocapsules)
RN  - 0 (Polyesters)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - P88XT4IS4D (Paclitaxel)
SB  - IM
MH  - Antineoplastic Agents, Phytogenic/*chemistry
MH  - Calorimetry, Differential Scanning
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Delayed-Action Preparations
MH  - Freeze Drying
MH  - Humans
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Microscopy, Electron, Transmission
MH  - Nanocapsules/*chemistry
MH  - Nanomedicine/methods
MH  - Paclitaxel/*chemistry
MH  - Particle Size
MH  - Polyesters/chemistry
MH  - Polyethylene Glycols/chemistry
MH  - Spectroscopy, Fourier Transform Infrared
OTO - NOTNLM
OT  - Keywords
OT  - freeze-dried nanoparticles
OT  - high solid content
OT  - nanoparticles
OT  - redispersibility
EDAT- 2014/06/05 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/06/05 06:00
PHST- 2014/06/05 06:00 [entrez]
PHST- 2014/06/05 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - 10.1080/09205063.2014.923365 [doi]
PST - ppublish
SO  - J Biomater Sci Polym Ed. 2014;25(11):1144-58. doi: 10.1080/09205063.2014.923365. 
      Epub 2014 Jun 4.