PMID- 2489534
OWN - NLM
STAT- MEDLINE
DCOM- 19910620
LR  - 20191029
IS  - 0385-0110 (Print)
IS  - 0385-0110 (Linking)
VI  - 31
IP  - 3
DP  - 1989 Sep
TI  - [Experimental study of periodontal tissue regeneration using biodegradable 
      membranes].
PG  - 870-81
AB  - This study was designed to investigate the effect on new attachment formation 
      using a biodegradable membrane as a barrier to the regeneration of periodontal 
      tissue. One-wall wide periodontal osseous defects with exposed root surfaces were 
      prepared in three adult mongrel dogs. After surgical debridement of the 
      periodontal defects, 3 types of biodegradable membranes, [Poly(L-lactic acid); 
      (P-L-LA)] membrane, [Poly(lactic acid-co-glycolic acid); (PLGA)] (81: 19 mole%) 
      membrane and PLGA (50: 50 mole%) membrane, were arranged to cover the denuded 
      root surfaces. Specimen blocks were removed 8 weeks postoperatively for 
      histological evaluation of their effect on the regeneration of periodontal 
      tissue. The results were as follows: 1. Gingival regions containing P-L-LA or 
      PLGA (81: 19 mole%) membranes showed delayed wound healing macroscopically. 2. 
      Almost all P-L-LA membranes were present in the experimental sites failing to be 
      resorbed during the 8-week experimental period. PLGA (81: 19 mole%) membranes 
      were also present but showed with some degree of resorption and fragility, while 
      PLGA (50: 50 mole%) membranes were completely resorbed. 3. This showed that the 
      membranes used in this experiment are possible barriers to the generation of new 
      attachment. It is important to make sure keeping the membrane. 4. There was no 
      relationship between osteogenesis and cementogenesis. It seems that osteogenesis 
      was depressed by membrane shrinkage and the gingival pressure which limited "the 
      regenerative space of bone." 5. Moderate resorption was observed on the root 
      surface, and new cementum was formed at the resorbed surface. 6. Ankylosis was 
      observed between the new cementum and bone at the experimental sites. Newly 
      formed cementum was seen on coronal sections of this area.
FAU - Kubota, K
AU  - Kubota K
FAU - Ochi, R
AU  - Ochi R
FAU - Tuge, Y
AU  - Tuge Y
FAU - Naitoh, T
AU  - Naitoh T
FAU - Hayashikawa, T
AU  - Hayashikawa T
FAU - Hitaka, M
AU  - Hitaka M
FAU - Soh, Y
AU  - Soh Y
FAU - Yamamoto, H
AU  - Yamamoto H
FAU - Okada, T
AU  - Okada T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Shishubyo Gakkai Kaishi
JT  - Nihon Shishubyo Gakkai kaishi
JID - 7505760
RN  - 0 (Membranes, Artificial)
MH  - Animals
MH  - *Bone Regeneration
MH  - Dental Cementum
MH  - Dogs
MH  - Epithelial Attachment/physiology
MH  - *Membranes, Artificial
MH  - Periodontal Ligament/physiology
EDAT- 1989/09/01 00:00
MHDA- 1989/09/01 00:01
CRDT- 1989/09/01 00:00
PHST- 1989/09/01 00:00 [pubmed]
PHST- 1989/09/01 00:01 [medline]
PHST- 1989/09/01 00:00 [entrez]
AID - 10.2329/perio.31.870 [doi]
PST - ppublish
SO  - Nihon Shishubyo Gakkai Kaishi. 1989 Sep;31(3):870-81. doi: 10.2329/perio.31.870.