PMID- 24895507
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140604
LR  - 20220419
IS  - 1869-3474 (Print)
IS  - 1869-3482 (Electronic)
IS  - 1869-3474 (Linking)
VI  - 47
IP  - 1
DP  - 2013 Mar
TI  - Differential Diagnosis of Parkinsonism Using Dual-Phase F-18 FP-CIT PET Imaging.
PG  - 44-51
LID - 10.1007/s13139-012-0182-4 [doi]
AB  - PURPOSE: Dopamine transporter (DAT) imaging can demonstrate presynaptic 
      dopaminergic neuronal loss in Parkinson's disease (PD). However, differentiating 
      atypical parkinsonism (APD) from PD is often difficult. We investigated the 
      usefulness of dual-phase F-18 FP-CIT positron emission tomography (PET) imaging 
      in the differential diagnosis of parkinsonism. METHODS: Ninety-eight subjects 
      [five normal, seven drug-induced parkinsonism (DIP), five essential tremor (ET), 
      24 PD, 20 multiple system atrophy-parkinson type (MSA-P), 13 multiple system 
      atrophy-cerebellar type (MSA-C), 13 progressive supranuclear palsy (PSP), and 11 
      dementia with Lewy bodies (DLB)] underwent F-18 FP-CIT PET. PET images were 
      acquired at 5 min (early phase) and 3 h (late phase) after F-18 FP-CIT 
      administration (185 MBq). Regional uptake pattern of cerebral and cerebellar 
      hemispheres was assessed on early phase images and striatal DAT binding pattern 
      was assessed on late phase images, using visual, quantitative, and statistical 
      parametric mapping (SPM) analyses. RESULTS: Striatal DAT binding was normal in 
      normal, ET, DIP, and MSA-C groups, but abnormal in PD, MSA-P, PSP, and DLB 
      groups. No difference was found in regional uptake on early phase images among 
      normal DAT binding groups, except in the MSA-C group. Abnormal DAT binding groups 
      showed different regional uptake pattern on early phase images compared with PD 
      in SPM analysis (FDR < 0.05). When discriminating APD from PD, visual 
      interpretation of the early phase image showed high diagnostic sensitivity and 
      specificity (75.4 % and 100 %, respectively). Regarding the ability to 
      distinguish specific APD, sensitivities were 81 % for MSA-P, 77 % for MSA-C, 23 % 
      for PSP, and 54.5 % for DLB. CONCLUSIONS: Dual-phase F-18 FP-CIT PET imaging is 
      useful in demonstrating striatal DAT loss in neurodegenerative parkinsonism, and 
      also in differentiating APD, particularly MSA, from PD.
FAU - Jin, Soyoung
AU  - Jin S
AD  - Department of Nuclear Medicine, Asan Medical Center, College of Medicine, 
      University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736 South 
      Korea.
FAU - Oh, Minyoung
AU  - Oh M
AD  - Department of Nuclear Medicine, Asan Medical Center, College of Medicine, 
      University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736 South 
      Korea.
FAU - Oh, Seung Jun
AU  - Oh SJ
AD  - Department of Nuclear Medicine, Asan Medical Center, College of Medicine, 
      University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736 South 
      Korea.
FAU - Oh, Jungsu S
AU  - Oh JS
AD  - Department of Nuclear Medicine, Asan Medical Center, College of Medicine, 
      University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736 South 
      Korea.
FAU - Lee, Sang Ju
AU  - Lee SJ
AD  - Department of Nuclear Medicine, Asan Medical Center, College of Medicine, 
      University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736 South 
      Korea.
FAU - Chung, Sun Ju
AU  - Chung SJ
AD  - Department of Neurology, Asan Medical Center, College of Medicine, University of 
      Ulsan, Seoul, South Korea.
FAU - Lee, Chong Sik
AU  - Lee CS
AD  - Department of Neurology, Asan Medical Center, College of Medicine, University of 
      Ulsan, Seoul, South Korea.
FAU - Kim, Jae Seung
AU  - Kim JS
AD  - Department of Nuclear Medicine, Asan Medical Center, College of Medicine, 
      University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736 South 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20121103
PL  - Germany
TA  - Nucl Med Mol Imaging
JT  - Nuclear medicine and molecular imaging
JID - 101530478
PMC - PMC4035208
OTO - NOTNLM
OT  - Atypical parkinsonism
OT  - Dual-phase
OT  - F-18 FP-CIT
OT  - PET
OT  - Positron emission tomography
EDAT- 2013/03/01 00:00
MHDA- 2013/03/01 00:01
PMCR- 2013/03/01
CRDT- 2014/06/05 06:00
PHST- 2012/04/05 00:00 [received]
PHST- 2012/10/09 00:00 [revised]
PHST- 2012/10/11 00:00 [accepted]
PHST- 2014/06/05 06:00 [entrez]
PHST- 2013/03/01 00:00 [pubmed]
PHST- 2013/03/01 00:01 [medline]
PHST- 2013/03/01 00:00 [pmc-release]
AID - 182 [pii]
AID - 10.1007/s13139-012-0182-4 [doi]
PST - ppublish
SO  - Nucl Med Mol Imaging. 2013 Mar;47(1):44-51. doi: 10.1007/s13139-012-0182-4. Epub 
      2012 Nov 3.