PMID- 24895735
OWN - NLM
STAT- MEDLINE
DCOM- 20141224
LR  - 20191112
IS  - 1440-1819 (Electronic)
IS  - 1323-1316 (Linking)
VI  - 68
IP  - 3
DP  - 2014 Mar
TI  - Psychosocial functioning is correlated with activation in the anterior cingulate 
      cortex and left lateral prefrontal cortex during a verbal fluency task in 
      euthymic bipolar disorder: a preliminary fMRI study.
PG  - 188-96
AB  - AIM: Cognitive impairment may account for functional and occupational disability 
      in patients with bipolar disorder even during periods of euthymia. While imaging 
      suggests structural, neurochemical, and functional abnormalities in bipolar 
      disorder patients, the pathophysiology of these deficits has not been elucidated. 
      It was hypothesized that euthymic bipolar patients would have different cortical 
      activation during a verbal fluency task compared to healthy controls, and that 
      psychosocial functioning would be associated with prefrontal cortical activation 
      during the task in the bipolar group. METHODS: Ten euthymic bipolar patients and 
      10 healthy control participants (matched for age, gender, and years of education) 
      underwent functional magnetic resonance imaging (fMRI) during a verbal fluency 
      task, tapping task and visual task. Correlational analysis between the fMRI brain 
      activation and clinical variables of the participants, including Global 
      Assessment of Functioning (GAF) score, was performed. RESULTS: Compared to the 
      controls, euthymic bipolar patients had significantly greater activation in the 
      bilateral precuneus with similar behavioral performance during the verbal fluency 
      task. There were no significant differences between the groups for the visual 
      task or the simple motor task. Activation in both the left anterior cingulate 
      cortex (ACC) and the left dorsolateral prefrontal cortex (PFC) were significantly 
      positively correlated with GAF score in the euthymic bipolar patients. 
      CONCLUSION: Both the ACC and lateral PFC regions are components of a neural 
      network that plays a critical role in psychosocial functioning, and are often 
      found to be affected in bipolar patients.
FAU - Yoshimura, Yasushi
AU  - Yoshimura Y
FAU - Okamoto, Yasumasa
AU  - Okamoto Y
FAU - Onoda, Keiichi
AU  - Onoda K
FAU - Okada, Go
AU  - Okada G
FAU - Toki, Shigeru
AU  - Toki S
FAU - Yoshino, Atsuo
AU  - Yoshino A
FAU - Yamashita, Hidehisa
AU  - Yamashita H
FAU - Yamawaki, Shigeto
AU  - Yamawaki S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*physiopathology/*psychology
MH  - Brain Mapping
MH  - Female
MH  - Functional Neuroimaging
MH  - Gyrus Cinguli/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Prefrontal Cortex/*physiopathology
MH  - *Social Adjustment
MH  - Speech/*physiology
EDAT- 2014/06/05 06:00
MHDA- 2014/12/30 06:00
CRDT- 2014/06/05 06:00
PHST- 2014/06/05 06:00 [entrez]
PHST- 2014/06/05 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
AID - 10.1111/pcn.12115 [doi]
PST - ppublish
SO  - Psychiatry Clin Neurosci. 2014 Mar;68(3):188-96. doi: 10.1111/pcn.12115.