PMID- 24896141
OWN - NLM
STAT- MEDLINE
DCOM- 20150921
LR  - 20221207
IS  - 1098-8785 (Electronic)
IS  - 0735-1631 (Linking)
VI  - 30
IP  - 2
DP  - 2015 Feb
TI  - A pilot randomized, controlled trial of metformin versus insulin in women with 
      type 2 diabetes mellitus during pregnancy.
PG  - 163-70
LID - 10.1055/s-0034-1378144 [doi]
AB  - OBJECTIVE: Few studies support oral diabetic treatment in pregnant women with 
      type 2 diabetes mellitus (T2DM). The objective of this study was to compare the 
      effects of metformin versus insulin on achieving glycemic control and improving 
      maternal and neonatal outcomes in pregnant women with T2DM. STUDY DESIGN: A pilot 
      randomized, controlled trial was conducted of metformin versus insulin for the 
      treatment of T2DM during pregnancy. The primary outcome was glycemic control 
      measured with hemoglobin A1c < 7% at delivery. Maternal and neonatal outcomes 
      were compared between groups. RESULTS: In this study, 8 women received metformin 
      and 11 received insulin. All women in both groups achieved glycemic control by 
      delivery (HgbA1c: metformin 5.96 +/- 5.88 vs. insulin 6.34 +/- 0.92%). There were 
      similar rates of cesarean delivery, birth weights, neonatal intensive care unit 
      admissions, respiratory distress syndrome, and neonatal dextrose treatment 
      between groups. There was one case of fetal macrosomia in the insulin group, one 
      case of shoulder dystocia in the metformin group and no cases of failed metformin 
      therapy. CONCLUSION: In this pilot study, glycemic control was achieved in women 
      who received metformin and insulin. Larger studies are needed to determine 
      whether metformin can be considered a reasonable alternative to insulin in 
      pregnant women with T2DM.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Refuerzo, Jerrie S
AU  - Refuerzo JS
AD  - Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and 
      Reproductive Sciences, University of Texas Health Science Center at Houston, 
      Houston, Texas.
FAU - Gowen, Rose
AU  - Gowen R
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, University of 
      Texas Health Science Center at Brownsville, Brownsville, Texas.
FAU - Pedroza, Claudia
AU  - Pedroza C
AD  - Center for Clinical Research and Evidence-Based Medicine, University of Texas 
      Health Science Center at Houston, Houston, Texas.
FAU - Hutchinson, Maria
AU  - Hutchinson M
AD  - Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and 
      Reproductive Sciences, University of Texas Health Science Center at Houston, 
      Houston, Texas.
FAU - Blackwell, Sean C
AU  - Blackwell SC
AD  - Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and 
      Reproductive Sciences, University of Texas Health Science Center at Houston, 
      Houston, Texas.
FAU - Ramin, Susan
AU  - Ramin S
AD  - Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, 
      Baylor College of Medicine, Houston, Texas.
LA  - eng
GR  - UL1TR000371/TR/NCATS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20140604
PL  - United States
TA  - Am J Perinatol
JT  - American journal of perinatology
JID - 8405212
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Adult
MH  - *Birth Weight
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/*drug therapy/metabolism
MH  - Dystocia
MH  - Female
MH  - Fetal Macrosomia
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Infant, Newborn
MH  - Insulin/*therapeutic use
MH  - Metformin/*therapeutic use
MH  - Pilot Projects
MH  - Pregnancy
MH  - Pregnancy in Diabetics/*drug therapy/metabolism
MH  - Treatment Outcome
EDAT- 2014/06/05 06:00
MHDA- 2015/09/22 06:00
CRDT- 2014/06/05 06:00
PHST- 2014/06/05 06:00 [entrez]
PHST- 2014/06/05 06:00 [pubmed]
PHST- 2015/09/22 06:00 [medline]
AID - 10.1055/s-0034-1378144 [doi]
PST - ppublish
SO  - Am J Perinatol. 2015 Feb;30(2):163-70. doi: 10.1055/s-0034-1378144. Epub 2014 Jun 
      4.