PMID- 24896160
OWN - NLM
STAT- MEDLINE
DCOM- 20141223
LR  - 20211021
VI  - 29
IP  - 1
DP  - 2014 Jan-Mar
TI  - Cardiac resynchronization therapy in patients with chronic Chagas cardiomyopathy: 
      long-term follow up.
PG  - 31-6
LID - S0102-76382014000100008 [pii]
AB  - INTRODUCTION: Chagas disease is a major cause of cardiomyopathy and sudden death 
      in our country. It has a high mortality when their patients develop New York 
      Heart Association (NYHA) class IV. OBJECTIVE: The objective of this study is to 
      analyze the clinical outcome of patients with Chagas' cardiomyopathy with 
      congestive heart failure with optimized pharmacological therapy, undergoing 
      cardiac resynchronization therapy. METHODS: Between January 2004 and February 
      2009, 72 patients with Chagas' cardiomyopathy in NYHA class III and IV underwent 
      cardiac resynchronization therapy and were monitored to assess their clinical 
      evolution. We used the t test or the Wilcoxon test to compare the same variable 
      in two different times. A P value < 0.05 was established as statistically 
      significant. RESULTS: The average clinical follow-up was 46.6 months (range 4-79 
      months). At the end of the evaluation, 87.4% of patients were in NYHA class I or 
      II (P<0.001). There was response to therapy in 65.3% of patients (P<0.001), with 
      an overall mortality of 34.7%. CONCLUSION: In patients with chronic Chagas 
      cardiomyopathy undergoing cardiac resynchronization therapy, we found the 
      following statistically significant changes: improvement in NYHA class and 
      increase of left ventricle ejection fraction, a decrease of the systolic final 
      diameter and systolic final left ventricle volume and improvement of patient 
      survival.
FAU - Araujo, Edgard Ferreira de
AU  - Araujo EF
AD  - Centro Cardiologico de Salinas, Salinas, MG, Brasil.
FAU - Chamlian, Eduardo Gregorio
AU  - Chamlian EG
AD  - Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Sao Paulo, SP, Brasil.
FAU - Peroni, Alexey Pomares
AU  - Peroni AP
AD  - Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Sao Paulo, SP, Brasil.
FAU - Pereira, Wilson Lopes
AU  - Pereira WL
AD  - Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Sao Paulo, SP, Brasil.
FAU - Gandra, Sylvio Matheus de Aquino
AU  - Gandra SM
AD  - Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Sao Paulo, SP, Brasil.
FAU - Rivetti, Luiz Antonio
AU  - Rivetti LA
AD  - Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Sao Paulo, SP, Brasil.
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Rev Bras Cir Cardiovasc
JT  - Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade 
      Brasileira de Cirurgia Cardiovascular
JID - 9104279
SB  - IM
CIN - Rev Bras Cir Cardiovasc. 2014 Jan-Mar;29(1):IV-VI. PMID: 24896174
MH  - Cardiac Resynchronization Therapy/*methods
MH  - Cardiac Resynchronization Therapy Devices
MH  - Chagas Cardiomyopathy/mortality/physiopathology/*therapy
MH  - Chronic Disease
MH  - Death, Sudden, Cardiac
MH  - Echocardiography, Doppler
MH  - Electrocardiography
MH  - Follow-Up Studies
MH  - Heart Failure/mortality/physiopathology/*therapy
MH  - Humans
MH  - Statistics, Nonparametric
MH  - Stroke Volume/physiology
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Function, Left
PMC - PMC4389487
EDAT- 2014/06/05 06:00
MHDA- 2014/12/24 06:00
PMCR- 2014/01/01
CRDT- 2014/06/05 06:00
PHST- 2013/05/22 00:00 [received]
PHST- 2013/11/24 00:00 [accepted]
PHST- 2014/06/05 06:00 [entrez]
PHST- 2014/06/05 06:00 [pubmed]
PHST- 2014/12/24 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - S0102-76382014000100008 [pii]
AID - 10.5935/1678-9741.20140008 [doi]
PST - ppublish
SO  - Rev Bras Cir Cardiovasc. 2014 Jan-Mar;29(1):31-6. doi: 
      10.5935/1678-9741.20140008.