PMID- 24897237
OWN - NLM
STAT- MEDLINE
DCOM- 20150925
LR  - 20220321
IS  - 1607-842X (Electronic)
IS  - 0891-6934 (Linking)
VI  - 47
IP  - 7
DP  - 2014 Nov
TI  - Interleukin-18 gene promoter--607 A/C polymorphism and the risk of immune 
      thrombocytopenia.
PG  - 478-81
LID - 10.3109/08916934.2014.921812 [doi]
AB  - Interleukin-18 (IL-18) is a T helper 1 cytokine, which is postulated to play a 
      role in immune thrombocytopenia (ITP). The aim of this study was to determine 
      whether IL-18 promoter gene -607 A/C polymorphism was associated with ITP. 
      Three-hundred and fifty-four Chinese ITP patients and 300 Chinese healthy 
      individuals were enrolled. Genomic DNA was extracted from the peripheral blood. 
      Polymerase chain reaction-restriction fragment length polymorphism (RFLP) was 
      used to genotype the DNA samples for single nucleotide polymorphism (SNP)-607. 
      Allelic and genotypic frequencies were compared between the case-control groups 
      by the chi-square test. The results showed that the frequencies of the CC, CA and 
      AA genotypes and C and A allele were 32.4, 47.8, 19.8, 56.4 and 43.6% in ITP 
      patients and 32.3, 50.4, 17.3, 57.5 and 42.5% in the controls, respectively. 
      There was no significant difference in either genotypes or allelic distribution 
      between ITP patients and the controls. Furthermore, stratified analysis by the 
      platelet count, age and disease course including ITP with severe thrombocytopenia 
      (sITP), non-sITP, acute adult, chronic adult, acute childhood and chronic 
      childhood revealed no significant difference in genotype and alleles 
      distribution. In conclusion, this polymorphism was almost equally distributed 
      between ITP patients and the controls. These data showed that this SNP may not be 
      used as a stratification marker to predict the susceptibility to Chinese ITP.
FAU - Zhao, Haifeng
AU  - Zhao H
AD  - Key Laboratory of Cancer Prevention and Therapy, Department of Hematology and 
      Oncology, Tianjin Medical University Cancer Institute and Hospital, National 
      Clinical Research Center for Cancer , Tianjin , PR China and.
FAU - Zhang, Yizhuo
AU  - Zhang Y
FAU - Xiao, Gangfeng
AU  - Xiao G
FAU - Wu, Ningning
AU  - Wu N
FAU - Xu, Jianfen
AU  - Xu J
FAU - Fang, Zhi
AU  - Fang Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140604
PL  - England
TA  - Autoimmunity
JT  - Autoimmunity
JID - 8900070
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Purpura, Thrombocytopenic, Idiopathic/*genetics/immunology
MH  - Young Adult
OTO - NOTNLM
OT  - IL-18
OT  - ITP
OT  - polymorphism
EDAT- 2014/06/05 06:00
MHDA- 2015/09/26 06:00
CRDT- 2014/06/05 06:00
PHST- 2014/06/05 06:00 [entrez]
PHST- 2014/06/05 06:00 [pubmed]
PHST- 2015/09/26 06:00 [medline]
AID - 10.3109/08916934.2014.921812 [doi]
PST - ppublish
SO  - Autoimmunity. 2014 Nov;47(7):478-81. doi: 10.3109/08916934.2014.921812. Epub 2014 
      Jun 4.