PMID- 24898701
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20201019
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 84
IP  - 2
DP  - 2014 Aug
TI  - Functional polymorphisms of interleukin-18 gene and risk of breast cancer in a 
      Brazilian population.
PG  - 229-33
LID - 10.1111/tan.12367 [doi]
AB  - Interleukin-18 (IL-18) is a key cytokine responsible for immune response and 
      involved in the process of cancer development. In this case-control study, we 
      tested whether IL-18 promoter polymorphism contributes to breast cancer 
      susceptibility in Brazilian patients. The two groups studied were 154 patients 
      with breast cancer and 118 healthy individuals. The frequency of IL-18 promoter 
      single nucleotide polymorphisms (SNPs) at positions -607 (C/A) (rs1946518) and 
      -137 (G/C) (rs187238) was determined by polymerase chain reaction analyses. The 
      polymorphisms genotyped in this study showed a significant association with 
      breast cancer under different genetic models. Both SNPs showed a positive 
      association. For the IL18-607 polymorphism the best model was the codominant 
      genetic model [CC vs AA, P = 0.004, odds ratio (OR) = 2.782, 95% confidence 
      interval (CI) 1.385-5.589]. For IL18-137 statistical significance was found using 
      the recessive genetic model (P = 0.008, OR = 3.896, 95% CI 1.427-10.639). The 
      association between the haplotypes of the IL18 gene and breast cancer was further 
      confirmed. Our results suggest that IL18-607 and IL18-137 polymorphism 
      contributes to increase the breast cancer risk. To our knowledge, this is the 
      first report regarding Brazilian breast cancer patients and IL18 promoter 
      polymorphisms.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Back, L K d C
AU  - Back LK
AD  - Departamento de Biologia, Embriologia e Genetica (UFSC - BEG), Universidade 
      Federal de Santa Catarina, Florianopolis, Brazil; Molecular Diagnostic, 
      Biogenetika, Florianopolis, Brazil.
FAU - Farias, T D J
AU  - Farias TD
FAU - da Cunha, P A
AU  - da Cunha PA
FAU - Muniz, Y C N
AU  - Muniz YC
FAU - Ribeiro, M C M
AU  - Ribeiro MC
FAU - Fernandes, B L
AU  - Fernandes BL
FAU - Fernandes, C K
AU  - Fernandes CK
FAU - de Souza, I R
AU  - de Souza IR
LA  - eng
PT  - Journal Article
DEP - 20140605
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (IL18 protein, human)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Brazil
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency/genetics
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes/genetics
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Risk Factors
OTO - NOTNLM
OT  - breast cancer
OT  - interleukin-18
OT  - polymorphisms
EDAT- 2014/06/06 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/06/06 06:00
PHST- 2013/09/19 00:00 [received]
PHST- 2014/02/27 00:00 [revised]
PHST- 2014/04/14 00:00 [accepted]
PHST- 2014/06/06 06:00 [entrez]
PHST- 2014/06/06 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.1111/tan.12367 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 Aug;84(2):229-33. doi: 10.1111/tan.12367. Epub 2014 Jun 5.