PMID- 24898921
OWN - NLM
STAT- MEDLINE
DCOM- 20150806
LR  - 20221207
IS  - 1476-5527 (Electronic)
IS  - 0950-9240 (Linking)
VI  - 29
IP  - 1
DP  - 2015 Jan
TI  - Attenuated brain-derived neurotrophic factor and hypertrophic remodelling: the 
      SABPA study.
PG  - 33-9
LID - 10.1038/jhh.2014.39 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has been linked to neurological 
      pathologies, but its role in cardiometabolic disturbances is limited. We aimed to 
      assess the association between serum BDNF levels and structural endothelial 
      dysfunction (ED) as determined by cross-sectional wall area (CSWA) and 
      albumin/creatinine ratio (ACR) in black Africans. Ambulatory blood pressure (BP) 
      and ultrasound CSWA values were obtained from 82 males and 90 females. Fasting 
      blood and 8 h overnight urine samples were collected to determine serum BDNF and 
      cardiometabolic risk markers, that is, glycated haemoglobin (HbA1c), lipids, 
      inflammation and ACR. BDNF median split x gender interaction effects for 
      structural ED justified stratification of BDNF into low and high 
      (⩽/>1.37 ng ml(-1)) gender groups. BDNF values (0.86-1.98 ng ml(-1)) were 
      substantially lower than reference ranges (6.97-42.6 ng ml(-1)) in the African 
      gender cohort, independent of age and body mass index. No relationship was 
      revealed between BDNF and renal function and was opposed by an inverse 
      relationship between BDNF and CSWA (r=-0.17; P=0.03) in the African cohort. 
      Linear regression analyses revealed a positive relationship between systolic BP 
      and structural remodelling in the total cohort and low-BDNF gender groups. In the 
      high-BDNF females, HbA1C was associated with structural remodelling. Attenuated 
      or possible downregulated BDNF levels were associated with hypertrophic 
      remodelling, and may be a compensatory mechanism for the higher BP in Africans. 
      In addition, metabolic risk and hypertrophic remodelling in women with high BDNF 
      underpin different underlying mechanisms for impaired neurotrophin homeostasis in 
      men and women.
FAU - Smith, A J
AU  - Smith AJ
AD  - Hypertension in Africa Research Team (HART), School for Physiology, Nutrition and 
      Consumer Sciences, North-West University, Potchefstroom, South Africa.
FAU - Malan, L
AU  - Malan L
AD  - Hypertension in Africa Research Team (HART), School for Physiology, Nutrition and 
      Consumer Sciences, North-West University, Potchefstroom, South Africa.
FAU - Uys, A S
AU  - Uys AS
AD  - Hypertension in Africa Research Team (HART), School for Physiology, Nutrition and 
      Consumer Sciences, North-West University, Potchefstroom, South Africa.
FAU - Malan, N T
AU  - Malan NT
AD  - Hypertension in Africa Research Team (HART), School for Physiology, Nutrition and 
      Consumer Sciences, North-West University, Potchefstroom, South Africa.
FAU - Harvey, B H
AU  - Harvey BH
AD  - Center of Excellence for Pharmaceutical Sciences, Division of Pharmacology, 
      School for Pharmacy, North-West University, Potchefstroom, South Africa.
FAU - Ziemssen, T
AU  - Ziemssen T
AD  - Department of Neurology, Medical Faculty Carl Gustav Carus, Technische 
      Universitat, Dresden, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140605
PL  - England
TA  - J Hum Hypertens
JT  - Journal of human hypertension
JID - 8811625
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - *Black People
MH  - Blood Pressure
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Carotid Arteries/metabolism/*physiopathology
MH  - Carotid Artery Diseases/blood/diagnosis/*ethnology/physiopathology
MH  - Chi-Square Distribution
MH  - Down-Regulation
MH  - Endothelium, Vascular/metabolism/physiopathology
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Sex Factors
MH  - South Africa/epidemiology
MH  - *Vascular Remodeling
MH  - Young Adult
EDAT- 2014/06/06 06:00
MHDA- 2015/08/08 06:00
CRDT- 2014/06/06 06:00
PHST- 2013/10/25 00:00 [received]
PHST- 2014/03/25 00:00 [revised]
PHST- 2014/04/02 00:00 [accepted]
PHST- 2014/06/06 06:00 [entrez]
PHST- 2014/06/06 06:00 [pubmed]
PHST- 2015/08/08 06:00 [medline]
AID - jhh201439 [pii]
AID - 10.1038/jhh.2014.39 [doi]
PST - ppublish
SO  - J Hum Hypertens. 2015 Jan;29(1):33-9. doi: 10.1038/jhh.2014.39. Epub 2014 Jun 5.