PMID- 24899123
OWN - NLM
STAT- MEDLINE
DCOM- 20160314
LR  - 20231031
IS  - 1724-6059 (Electronic)
IS  - 1121-8428 (Print)
IS  - 1121-8428 (Linking)
VI  - 28
IP  - 1
DP  - 2015 Feb
TI  - Urine interleukin-18 in prediction of acute kidney injury: a systemic review and 
      meta-analysis.
PG  - 7-16
LID - 10.1007/s40620-014-0113-9 [doi]
AB  - BACKGROUND: Interleukin-18 (IL-18) mediates ischemic acute tubular necrosis; it 
      has been proved as a rapid, reliable, and affordable test marker for the early 
      detection of acute kidney injury (AKI), but its predictive accuracy varies 
      greatly. METHODS: MEDLINE and EMBASE, Cochrane Library, Ovid, and Springerlink 
      (from inception to November 15, 2013) were searched for relevant studies (in 
      English) investigating diagnostic accuracy of urine IL-18 to predict AKI in 
      various clinical settings. The text index was increasing or increased urine IL-18 
      level and the main outcome was the development of AKI, which was primarily based 
      on serum creatinine level [using risk, injury, failure, loss and end-stage renal 
      disease (RIFLE), acute kidney injury network, or modified pediatric RIFLE 
      criteria in pediatric patients]. Pooled estimates of diagnostic odds ratio (OR), 
      sensitivity and specificity were calculated. Summary receiver operating 
      characteristic curves were used to calculate the measures of accuracy and Q point 
      value (Q*). Remarkable heterogeneity was explored further by subgroup analysis 
      based on the different clinical settings. RESULTS: We analyzed data from 11 
      studies of 3 countries covering 2,796 patients. These studies were marked by 
      limitations of threshold and non-threshold effect heterogeneity. Across all 
      settings, the diagnostic OR for urine IL-18 level to predict AKI was 5.11 [95% 
      confidence interval (CI) 3.22-8.12], with sensitivity and specificity 
      respectively at 0.51 and 0.79. The area under the ROC curve of urine IL-18 level 
      to predict AKI was 0.77 (95% CI 0.71-0.83). Subgroup analysis showed that urine 
      IL-18 level in pediatric patients (<18 years) and early AKI predictive time (<12 
      h) were more effective in predicting AKI, with diagnostic ORs of 7.51 
      (2.99-18.88), 8.18 (2.19-30.51), respectively. CONCLUSION: Urine IL-18 holds 
      promise as a biomarker in the prediction of AKI but has only moderate diagnostic 
      value.
FAU - Lin, Xin
AU  - Lin X
AD  - Department of Nephrology, People's Hospital of Guizhou Province, No. 83, 
      Zhongshan East Road, Guiyang, 550002, Guizhou, People's Republic of China.
FAU - Yuan, Jing
AU  - Yuan J
FAU - Zhao, Yingting
AU  - Zhao Y
FAU - Zha, Yan
AU  - Zha Y
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20140605
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-18)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Acute Kidney Injury/blood/*diagnosis/urine
MH  - Age Factors
MH  - Area Under Curve
MH  - Biomarkers/urine
MH  - Creatinine/blood
MH  - Humans
MH  - Interleukin-18/*urine
MH  - Predictive Value of Tests
MH  - ROC Curve
PMC - PMC4322238
EDAT- 2014/06/06 06:00
MHDA- 2016/03/15 06:00
PMCR- 2014/06/05
CRDT- 2014/06/06 06:00
PHST- 2014/02/10 00:00 [received]
PHST- 2014/05/15 00:00 [accepted]
PHST- 2014/06/06 06:00 [entrez]
PHST- 2014/06/06 06:00 [pubmed]
PHST- 2016/03/15 06:00 [medline]
PHST- 2014/06/05 00:00 [pmc-release]
AID - 113 [pii]
AID - 10.1007/s40620-014-0113-9 [doi]
PST - ppublish
SO  - J Nephrol. 2015 Feb;28(1):7-16. doi: 10.1007/s40620-014-0113-9. Epub 2014 Jun 5.