PMID- 24899575
OWN - NLM
STAT- MEDLINE
DCOM- 20150220
LR  - 20140801
IS  - 1529-7268 (Electronic)
IS  - 0006-3363 (Linking)
VI  - 91
IP  - 1
DP  - 2014 Jul
TI  - Physical and mental development of children after levonorgestrel emergency 
      contraception exposure: a follow-up prospective cohort study.
PG  - 27
LID - 10.1095/biolreprod.113.117226 [doi]
AB  - Levonorgestrel (LNG), a dedicated emergency contraception (EC) product, has been 
      available over-the-counter in China for more than 14 yr. Although LNG-EC is 
      considered to have no effects on the developing fetus if the contraceptive fails 
      and pregnancy occurs, there have been a few studies specifically examining this 
      issue. The purpose of this study was to compare the physical and mental 
      development of children born after LNG-EC failure with that of a cohort of 
      children born to mothers with no history of exposure to LNG or any teratogenic 
      substances. A group of 195 children who were exposed to LNG-EC during their 
      mothers' conception cycle (study group) were matched to a group of 214 children 
      without exposure to LNG (control group). The physical and mental development of 
      the children were evaluated and compared over a 2-yr period. There were four 
      congenital malformations in the study group and three in the control group (2.1% 
      vs. 1.4%, respectively, P > 0.05). Over the 2-yr follow-up period, there were no 
      statistically significant differences between the two groups with respect to 
      children's weight, height, head circumference, and intelligence scores, and the 
      values of all parameters of both groups were similar to those of the national 
      standards. In summary, LNG-EC has no effect on the physical growth, mental 
      development, or occurrence of birth defects in children born from pregnancies in 
      which EC failed.
CI  - (c) 2014 by the Society for the Study of Reproduction, Inc.
FAU - Zhang, Lin
AU  - Zhang L
AD  - Department of Obstetrics, MOE-Shanghai Key Laboratory of Children's Environmental 
      Health, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, 
      Shanghai, China.
FAU - Ye, Weiping
AU  - Ye W
AD  - Department of Obstetrics, Xinhua Hospital, Shanghai JiaoTong University School of 
      Medicine, Shanghai, China.
FAU - Yu, Wen
AU  - Yu W
AD  - Department of Child Health Care, International Peace Maternity and Child Health 
      Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
FAU - Cheng, Linan
AU  - Cheng L
AD  - Shanghai Institute of Planned Parenthood Research, Shanghai, China.
FAU - Shen, Lixiao
AU  - Shen L
AD  - Department of Child Health Care, MOE-Shanghai Key Laboratory of Children's 
      Environmental Health, Xinhua Hospital, Shanghai JiaoTong University School of 
      Medicine, Shanghai, China.
FAU - Yang, Zujing
AU  - Yang Z
AD  - Department of Obstetrics, MOE-Shanghai Key Laboratory of Children's Environmental 
      Health, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, 
      Shanghai, China Yzujing@sohu.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140604
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (Contraceptive Agents, Female)
RN  - 5W7SIA7YZW (Levonorgestrel)
SB  - IM
MH  - Abnormalities, Drug-Induced/*etiology
MH  - Child Development/*drug effects
MH  - Child, Preschool
MH  - China
MH  - Cohort Studies
MH  - Contraception, Postcoital/*adverse effects
MH  - Contraceptive Agents, Female/administration & dosage/*adverse effects
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Intelligence/*drug effects
MH  - Levonorgestrel/administration & dosage/*adverse effects
MH  - Male
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Prospective Studies
OTO - NOTNLM
OT  - childhood development
OT  - congenital malformations
OT  - emergency contraception
OT  - levonorgestrel
OT  - pregnancy
EDAT- 2014/06/06 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/06/06 06:00
PHST- 2014/06/06 06:00 [entrez]
PHST- 2014/06/06 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - biolreprod.113.117226 [pii]
AID - 10.1095/biolreprod.113.117226 [doi]
PST - ppublish
SO  - Biol Reprod. 2014 Jul;91(1):27. doi: 10.1095/biolreprod.113.117226. Epub 2014 Jun 
      4.