PMID- 24899826
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140606
LR  - 20211021
IS  - 1179-5468 (Print)
IS  - 1179-5468 (Electronic)
IS  - 1179-5468 (Linking)
VI  - 8
DP  - 2014
TI  - Effects of oral amino Acid supplements on functional capacity in patients with 
      chronic heart failure.
PG  - 39-44
LID - 10.4137/CMC.S14016 [doi]
AB  - Amino acids (AAs) availability is reduced in patients with heart failure (HF) 
      leading to abnormalities in cardiac and skeletal muscle metabolism, and 
      eventually to a reduction in functional capacity and quality of life. In this 
      study, we investigate the effects of oral supplementation with essential and 
      semi-essential AAs for three months in patients with stable chronic HF. The 
      primary endpoints were the effects of AA's supplementation on exercise tolerance 
      (evaluated by cardiopulmonary stress test and six minutes walking test (6MWT)), 
      whether the secondary endpoints were change in quality of life (evaluated by 
      Minnesota Living with Heart Failure Questionnaire-MLHFQ) and N-terminal pro-brain 
      natriuretic peptide (NT-proBNP) levels. We enrolled 13 patients with chronic 
      stable HF on optimal therapy, symptomatic in New York Heart Association (NYHA) 
      class II/III, with an ejection fraction (EF) <45%. The mean age was 59 +/- 14 
      years, and 11 (84.6%) patients were male. After three months, peak VO2 (baseline 
      14.8 +/- 3.9 mL/minute/kg vs follow-up 16.8 +/- 5.1 mL/minute/kg; P = 0.008) and VO2 
      at anaerobic threshold improved significantly (baseline 9.0 +/- 3.8 mL/minute/kg vs 
      follow-up 12.4 +/- 3.9 mL/minute/kg; P = 0.002), as the 6MWT distance (baseline 
      439.1 +/- 64.3 m vs follow-up 474.2 +/- 89.0 m; P = 0.006). However, the quality of 
      life did not change significantly (baseline 21 +/- 14 vs follow-up 25 +/- 13; P = 
      0.321). A non-significant trend in the reduction of NT-proBNP levels was observed 
      (baseline 1502 +/- 1900 ng/L vs follow-up 1040 +/- 1345 ng/L; P = 0.052). AAs 
      treatment resulted safe and was well tolerated by all patients. In our study, AAs 
      supplementation in patients with chronic HF improved exercise tolerance but did 
      not change quality of life.
FAU - Lombardi, Carlo
AU  - Lombardi C
AD  - Cardiology, Department of Medical and Surgical Specialties, Radiological 
      Sciences, and Public Health, University and Civil Hospital of Brescia, Brescia, 
      Italy.
FAU - Carubelli, Valentina
AU  - Carubelli V
AD  - Cardiology, Department of Medical and Surgical Specialties, Radiological 
      Sciences, and Public Health, University and Civil Hospital of Brescia, Brescia, 
      Italy.
FAU - Lazzarini, Valentina
AU  - Lazzarini V
AD  - Cardiology, Department of Medical and Surgical Specialties, Radiological 
      Sciences, and Public Health, University and Civil Hospital of Brescia, Brescia, 
      Italy.
FAU - Vizzardi, Enrico
AU  - Vizzardi E
AD  - Cardiology, Department of Medical and Surgical Specialties, Radiological 
      Sciences, and Public Health, University and Civil Hospital of Brescia, Brescia, 
      Italy.
FAU - Quinzani, Filippo
AU  - Quinzani F
AD  - Cardiology, Department of Medical and Surgical Specialties, Radiological 
      Sciences, and Public Health, University and Civil Hospital of Brescia, Brescia, 
      Italy.
FAU - Guidetti, Federica
AU  - Guidetti F
AD  - Cardiology, Department of Medical and Surgical Specialties, Radiological 
      Sciences, and Public Health, University and Civil Hospital of Brescia, Brescia, 
      Italy.
FAU - Rovetta, Riccardo
AU  - Rovetta R
AD  - Cardiology, Department of Medical and Surgical Specialties, Radiological 
      Sciences, and Public Health, University and Civil Hospital of Brescia, Brescia, 
      Italy.
FAU - Nodari, Savina
AU  - Nodari S
AD  - Cardiology, Department of Medical and Surgical Specialties, Radiological 
      Sciences, and Public Health, University and Civil Hospital of Brescia, Brescia, 
      Italy.
FAU - Gheorghiade, Mihai
AU  - Gheorghiade M
AD  - Cardiology, Department of Medical and Surgical Specialties, Radiological 
      Sciences, and Public Health, University and Civil Hospital of Brescia, Brescia, 
      Italy.
FAU - Metra, Marco
AU  - Metra M
AD  - Cardiology, Department of Medical and Surgical Specialties, Radiological 
      Sciences, and Public Health, University and Civil Hospital of Brescia, Brescia, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20140521
PL  - United States
TA  - Clin Med Insights Cardiol
JT  - Clinical Medicine Insights. Cardiology
JID - 101525768
PMC - PMC4039212
OTO - NOTNLM
OT  - amino acid
OT  - exercise capacity
OT  - heart failure
OT  - nutrition
OT  - systolic dysfunction
EDAT- 2014/06/06 06:00
MHDA- 2014/06/06 06:01
PMCR- 2014/05/21
CRDT- 2014/06/06 06:00
PHST- 2014/01/02 00:00 [received]
PHST- 2014/02/11 00:00 [revised]
PHST- 2014/02/15 00:00 [accepted]
PHST- 2014/06/06 06:00 [entrez]
PHST- 2014/06/06 06:00 [pubmed]
PHST- 2014/06/06 06:01 [medline]
PHST- 2014/05/21 00:00 [pmc-release]
AID - cmc-8-2014-039 [pii]
AID - 10.4137/CMC.S14016 [doi]
PST - epublish
SO  - Clin Med Insights Cardiol. 2014 May 21;8:39-44. doi: 10.4137/CMC.S14016. 
      eCollection 2014.