PMID- 24900242
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140605
LR  - 20240506
IS  - 1948-5875 (Print)
IS  - 1948-5875 (Electronic)
IS  - 1948-5875 (Linking)
VI  - 1
IP  - 9
DP  - 2010 Dec 9
TI  - Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral 
      Erythropoietin Secretagogues.
PG  - 526-9
LID - 10.1021/ml100198y [doi]
AB  - HIF prolyl 4-hydroxylases (PHD) are a family of enzymes that mediate key 
      physiological responses to hypoxia by modulating the levels of hypoxia inducible 
      factor 1-alpha (HIF1alpha). Certain benzimidazole-2-pyrazole carboxylates were discovered 
      to be PHD2 inhibitors using ligand- and structure-based methods and found to be 
      potent, orally efficacious stimulators of erythropoietin secretion in vivo.
FAU - Rosen, Mark D
AU  - Rosen MD
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Venkatesan, Hariharan
AU  - Venkatesan H
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Peltier, Hillary M
AU  - Peltier HM
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Bembenek, Scott D
AU  - Bembenek SD
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Kanelakis, Kimon C
AU  - Kanelakis KC
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Zhao, Lucy X
AU  - Zhao LX
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Leonard, Barry E
AU  - Leonard BE
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Hocutt, Frances M
AU  - Hocutt FM
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Wu, Xiaodong
AU  - Wu X
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Palomino, Heather L
AU  - Palomino HL
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Brondstetter, Theresa I
AU  - Brondstetter TI
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Haugh, Peter V
AU  - Haugh PV
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Cagnon, Laurence
AU  - Cagnon L
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Yan, Wen
AU  - Yan W
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Liotta, Lisa A
AU  - Liotta LA
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Young, Andrew
AU  - Young A
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Mirzadegan, Tara
AU  - Mirzadegan T
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Shankley, Nigel P
AU  - Shankley NP
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Barrett, Terrance D
AU  - Barrett TD
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
FAU - Rabinowitz, Michael H
AU  - Rabinowitz MH
AD  - Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield 
      Row, San Diego, California 92121, United States.
LA  - eng
PT  - Journal Article
DEP - 20101005
PL  - United States
TA  - ACS Med Chem Lett
JT  - ACS medicinal chemistry letters
JID - 101521073
PMC - PMC4007848
OTO - NOTNLM
OT  - HIF
OT  - PHD inhibitors
OT  - Prolyl 4-hydroxylase inhibitors
OT  - anemia
OT  - epo
OT  - erythropoietin
OT  - erythropoietin stimulating agents
OT  - hypoxia inducible factor
EDAT- 2010/12/09 00:00
MHDA- 2010/12/09 00:01
PMCR- 2011/12/09
CRDT- 2014/06/06 06:00
PHST- 2010/08/20 00:00 [received]
PHST- 2010/09/29 00:00 [accepted]
PHST- 2014/06/06 06:00 [entrez]
PHST- 2010/12/09 00:00 [pubmed]
PHST- 2010/12/09 00:01 [medline]
PHST- 2011/12/09 00:00 [pmc-release]
AID - 10.1021/ml100198y [doi]
PST - epublish
SO  - ACS Med Chem Lett. 2010 Oct 5;1(9):526-9. doi: 10.1021/ml100198y. eCollection 
      2010 Dec 9.