PMID- 24900511
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140605
LR  - 20211021
IS  - 1948-5875 (Print)
IS  - 1948-5875 (Electronic)
IS  - 1948-5875 (Linking)
VI  - 3
IP  - 7
DP  - 2012 Jul 12
TI  - Imidazo[1,2-a]pyridines That Directly Interact with Hepatitis C NS4B: Initial 
      Preclinical Characterization.
PG  - 565-9
LID - 10.1021/ml300090x [doi]
AB  - A series of imidazo[1,2-a]pyridines which directly bind to HCV Non-Structural 
      Protein 4B (NS4B) is described. This series demonstrates potent in vitro 
      inhibition of HCV replication (EC50 < 10 nM), direct binding to purified NS4B 
      protein (IC50 < 20 nM), and an HCV resistance pattern associated with NS4B 
      (H94N/R, V105L/M, F98L) that are unique among reported HCV clinical assets, 
      suggestive of the potential for additive or synergistic combination with other 
      small molecule inhibitors of HCV replication.
FAU - Shotwell, J Brad
AU  - Shotwell JB
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Baskaran, Subramanian
AU  - Baskaran S
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Chong, Pek
AU  - Chong P
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Creech, Katrina L
AU  - Creech KL
AD  - GlaxoSmithKline , Platform Technology and Science, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Crosby, Renae M
AU  - Crosby RM
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Dickson, Hamilton
AU  - Dickson H
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Fang, Jing
AU  - Fang J
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Garrido, Dulce
AU  - Garrido D
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Mathis, Amanda
AU  - Mathis A
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Maung, Jack
AU  - Maung J
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Parks, Derek J
AU  - Parks DJ
AD  - GlaxoSmithKline , Platform Technology and Science, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Pouliot, Jeffrey J
AU  - Pouliot JJ
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Price, Daniel J
AU  - Price DJ
AD  - GlaxoSmithKline , Platform Technology and Science, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Rai, Roopa
AU  - Rai R
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Seal, John W 3rd
AU  - Seal JW 3rd
AD  - GlaxoSmithKline , Platform Technology and Science, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Schmitz, Uli
AU  - Schmitz U
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Tai, Vincent W F
AU  - Tai VW
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Thomson, Michael
AU  - Thomson M
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Xie, Mi
AU  - Xie M
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Xiong, Zhiping Z
AU  - Xiong ZZ
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
FAU - Peat, Andrew J
AU  - Peat AJ
AD  - GlaxoSmithKline , Antiviral Discovery Performance Unit, 5 Moore Drive, Research 
      Triangle Park, North Carolina 27709-3398, United States.
LA  - eng
PT  - Journal Article
DEP - 20120524
PL  - United States
TA  - ACS Med Chem Lett
JT  - ACS medicinal chemistry letters
JID - 101521073
PMC - PMC4025644
OTO - NOTNLM
OT  - NS4B
OT  - hepatitis C virus
OT  - imidazo[1,2-a]pyridines
OT  - replicon
EDAT- 2012/07/12 00:00
MHDA- 2012/07/12 00:01
PMCR- 2013/07/12
CRDT- 2014/06/06 06:00
PHST- 2012/04/11 00:00 [received]
PHST- 2012/05/24 00:00 [accepted]
PHST- 2014/06/06 06:00 [entrez]
PHST- 2012/07/12 00:00 [pubmed]
PHST- 2012/07/12 00:01 [medline]
PHST- 2013/07/12 00:00 [pmc-release]
AID - 10.1021/ml300090x [doi]
PST - epublish
SO  - ACS Med Chem Lett. 2012 May 24;3(7):565-9. doi: 10.1021/ml300090x. eCollection 
      2012 Jul 12.