PMID- 24901010
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20211021
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2014
DP  - 2014
TI  - HLA associations and clinical implications in T-cell mediated drug 
      hypersensitivity reactions: an updated review.
PG  - 565320
LID - 10.1155/2014/565320 [doi]
LID - 565320
AB  - T-cell mediated drug hypersensitivity reactions may range from mild rash to 
      severe fatal reactions. Among them, drug reaction with eosinophilia and systemic 
      symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), 
      Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the 
      most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances 
      in pharmacogenetic studies show strong genetic associations between human 
      leukocyte antigen (HLA) alleles and susceptibility to drug hypersensitivity. This 
      review summarizes the literature on recent progresses in pharmacogenetic studies 
      and clinical application of pharmacogenetic screening based on associations 
      between SCARs and specific HLA alleles to avoid serious conditions associated 
      with drug hypersensitivity.
FAU - Cheng, Chi-Yuan
AU  - Cheng CY
AD  - Department of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 
      33305, Taiwan.
FAU - Su, Shih-Chi
AU  - Su SC
AUID- ORCID: 0000-0002-4263-7654
AD  - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, 
      Chang Gung Memorial Hospitals, Linkou 33305, Taiwan.
FAU - Chen, Chi-Hua
AU  - Chen CH
AD  - Department of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 
      33305, Taiwan.
FAU - Chen, Wei-Li
AU  - Chen WL
AD  - Department of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 
      33305, Taiwan.
FAU - Deng, Shin-Tarng
AU  - Deng ST
AD  - Department of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 
      33305, Taiwan.
FAU - Chung, Wen-Hung
AU  - Chung WH
AD  - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, 
      Chang Gung Memorial Hospitals, Linkou 33305, Taiwan ; College of Medicine, Chang 
      Gung University, Taoyuan 33302, Taiwan ; Department of Dermatology, Keelung Chang 
      Gung Memorial Hospital, No. 222 Maijin Road, Anle District, Keelung City 20448, 
      Taiwan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140508
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (Dideoxynucleosides)
RN  - 0 (HLA Antigens)
RN  - 33CM23913M (Carbamazepine)
RN  - 63CZ7GJN5I (Allopurinol)
RN  - WR2TIP26VS (abacavir)
SB  - IM
MH  - Alleles
MH  - Allopurinol/adverse effects
MH  - Carbamazepine/adverse effects
MH  - Dideoxynucleosides/adverse effects
MH  - Drug Hypersensitivity Syndrome/etiology/*genetics/immunology/pathology
MH  - Gene Expression
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Stevens-Johnson Syndrome/etiology/*genetics/immunology/pathology
MH  - T-Lymphocytes/drug effects/*immunology/pathology
PMC - PMC4034438
EDAT- 2014/06/06 06:00
MHDA- 2014/12/15 06:00
PMCR- 2014/05/08
CRDT- 2014/06/06 06:00
PHST- 2014/02/13 00:00 [received]
PHST- 2014/03/28 00:00 [accepted]
PHST- 2014/06/06 06:00 [entrez]
PHST- 2014/06/06 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2014/05/08 00:00 [pmc-release]
AID - 10.1155/2014/565320 [doi]
PST - ppublish
SO  - J Immunol Res. 2014;2014:565320. doi: 10.1155/2014/565320. Epub 2014 May 8.