PMID- 24901233
OWN - NLM
STAT- MEDLINE
DCOM- 20151005
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 6
DP  - 2014
TI  - Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.
PG  - e99296
LID - 10.1371/journal.pone.0099296 [doi]
LID - e99296
AB  - Interleukin (IL)-1 signaling plays an important role in inflammatory processes, 
      but also in malignant processes. The essential downstream event in IL-1 signaling 
      is the activation of nuclear factor (NF)-kappaB, which leads to the expression of 
      several genes that are involved in cell proliferation, invasion, angiogenesis and 
      metastasis, among them VEGF-A. As microenvironment-derived IL-1beta is required for 
      invasion and angiogenesis in malignant tumors, also in chondrosarcomas, we 
      investigated IL-1beta-induced signal transduction and VEGF-A expression in C3842 and 
      SW1353 chondrosarcoma cells. We additionally performed in vitro angiogenesis 
      assays and NF-kappaB-related gene expression analyses. Curcumin is a substance which 
      inhibits IL-1 signaling very early by preventing the recruitment of IL-1 receptor 
      associated kinase (IRAK) to the IL-1 receptor. We demonstrate that IL-1 signaling 
      and VEGF-A expression are blocked by Curcumin in chondrosarcoma cells. We further 
      show that Curcumin blocks IL-1beta-induced angiogenesis and NF-kappaB-related gene 
      expression. We suppose that IL-1 blockade is an additional treatment option in 
      chondrosarcoma, either by Curcumin, its derivatives or other IL-1 blocking 
      agents.
FAU - Kalinski, Thomas
AU  - Kalinski T
AD  - Department of Pathology, Otto-von-Guericke-University, Magdeburg, Germany.
FAU - Sel, Saadettin
AU  - Sel S
AD  - Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
FAU - Hutten, Heiko
AU  - Hutten H
AD  - Department of Hematology and Oncology, Klinikum Braunschweig, Braunschweig, 
      Germany.
FAU - Ropke, Martin
AU  - Ropke M
AD  - Department of Orthopedics, Otto-von-Guericke-University, Magdeburg, Germany.
FAU - Roessner, Albert
AU  - Roessner A
AD  - Department of Pathology, Otto-von-Guericke-University, Magdeburg, Germany.
FAU - Nass, Norbert
AU  - Nass N
AD  - Department of Pathology, Otto-von-Guericke-University, Magdeburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20140605
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Interleukin-1)
RN  - 0 (NF-kappa B)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 2.7.11.1 (Interleukin-1 Receptor-Associated Kinases)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Cell Line, Tumor
MH  - Chondrosarcoma/metabolism/pathology
MH  - Curcumin/*pharmacology
MH  - Gene Expression Regulation/drug effects
MH  - Human Umbilical Vein Endothelial Cells
MH  - Humans
MH  - Interleukin-1/antagonists & inhibitors/*metabolism/pharmacology
MH  - Interleukin-1 Receptor-Associated Kinases/metabolism
MH  - NF-kappa B/metabolism
MH  - Neovascularization, Physiologic/drug effects
MH  - Phosphorylation/drug effects
MH  - Receptors, Interleukin-1/metabolism
MH  - Signal Transduction/*drug effects
MH  - Vascular Endothelial Growth Factor A/metabolism
PMC - PMC4047106
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/06/06 06:00
MHDA- 2015/10/06 06:00
PMCR- 2014/06/05
CRDT- 2014/06/06 06:00
PHST- 2013/07/02 00:00 [received]
PHST- 2014/05/13 00:00 [accepted]
PHST- 2014/06/06 06:00 [entrez]
PHST- 2014/06/06 06:00 [pubmed]
PHST- 2015/10/06 06:00 [medline]
PHST- 2014/06/05 00:00 [pmc-release]
AID - PONE-D-13-27289 [pii]
AID - 10.1371/journal.pone.0099296 [doi]
PST - epublish
SO  - PLoS One. 2014 Jun 5;9(6):e99296. doi: 10.1371/journal.pone.0099296. eCollection 
      2014.