PMID- 24903161
OWN - NLM
STAT- MEDLINE
DCOM- 20141126
LR  - 20140930
IS  - 1535-3699 (Electronic)
IS  - 1535-3699 (Linking)
VI  - 239
IP  - 10
DP  - 2014 Oct
TI  - Vitamin B6 prevents cognitive impairment in experimental pneumococcal meningitis.
PG  - 1360-5
LID - 10.1177/1535370214535896 [doi]
AB  - Streptococcus pneumoniae is the relevant cause of bacterial meningitis, with a 
      high-mortality rate and long-term neurological sequelae, affecting up to 50% of 
      survivors. Pneumococcal compounds are pro-inflammatory mediators that induce an 
      innate immune response and tryptophan degradation through the kynurenine pathway. 
      Vitamin B6 acts as a cofactor at the active sites of enzymes that catalyze a 
      great number of reactions involved in the metabolism of tryptophan, preventing 
      the accumulation of neurotoxic intermediates. In the present study, we evaluated 
      the effects of vitamin B6 on memory and on brain-derived neurotrophic factor 
      (BDNF) expression in the brain of adult Wistar rats subjected to pneumococcal 
      meningitis. The animals received either 10 microL of artificial cerebral spinal fluid 
      (CSF) or an equivalent volume of S. pneumoniae suspension. The animals were 
      divided into four groups: control, control treated with vitamin B6, meningitis, 
      and meningitis treated with vitamin B6. Ten days after induction, the animals 
      were subjected to behavioral tests: open-field task and step-down inhibitory 
      avoidance task. In the open-field task, there was a significant reduction in both 
      crossing and rearing in the control group, control/B6 group, and meningitis/B6 
      group compared with the training session, demonstrating habituation memory. 
      However, the meningitis group showed no difference in motor and exploratory 
      activity between training and test sessions, demonstrating memory impairment. In 
      the step-down inhibitory avoidance task, there was a difference between training 
      and test sessions in the control group, control/B6 group, and meningitis/B6 
      group, demonstrating aversive memory. In the meningitis group, there was no 
      difference between training and test sessions, demonstrating impairment of 
      aversive memory. In the hippocampus, BDNF expression decreased in the meningitis 
      group when compared to the control group; however, adjuvant treatment with 
      vitamin B6 increased BDNF expression in the meningitis group. Thus, vitamin B6 
      attenuated the memory impairment in animals subjected to pneumococcal meningitis.
CI  - (c) 2014 by the Society for Experimental Biology and Medicine.
FAU - Barichello, Tatiana
AU  - Barichello T
AD  - Laboratorio de Microbiologia Experimental, Programa de Pos-Graduacao em Ciencias 
      da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul 
      Catarinense, 888806-000, Criciuma, SC, Brasil Center for Experimental Models in 
      Psychiatry, Department of Psychiatry and Behavioral Sciences, The University of 
      Texas Medical School at Houston, 77030, Houston, TX, USA tba@unesc.net.
FAU - Generoso, Jaqueline S
AU  - Generoso JS
AD  - Laboratorio de Microbiologia Experimental, Programa de Pos-Graduacao em Ciencias 
      da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul 
      Catarinense, 888806-000, Criciuma, SC, Brasil.
FAU - Simoes, Lutiana R
AU  - Simoes LR
AD  - Laboratorio de Microbiologia Experimental, Programa de Pos-Graduacao em Ciencias 
      da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul 
      Catarinense, 888806-000, Criciuma, SC, Brasil.
FAU - Ceretta, Renan A
AU  - Ceretta RA
AD  - Laboratorio de Microbiologia Experimental, Programa de Pos-Graduacao em Ciencias 
      da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul 
      Catarinense, 888806-000, Criciuma, SC, Brasil.
FAU - Dominguini, Diogo
AU  - Dominguini D
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      888806-000, Criciuma, SC, Brasil.
FAU - Ferrari, Pamela
AU  - Ferrari P
AD  - Laboratorio de Psiquiatria Molecular, Hospital de Clinicas de Porto Alegre, 
      Universidade Federal do Rio Grande do Sul, 90035003, Porto Alegre, RS, Brasil.
FAU - Gubert, Carolina
AU  - Gubert C
AD  - Laboratorio de Psiquiatria Molecular, Hospital de Clinicas de Porto Alegre, 
      Universidade Federal do Rio Grande do Sul, 90035003, Porto Alegre, RS, Brasil.
FAU - Jornada, Luciano K
AU  - Jornada LK
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      888806-000, Criciuma, SC, Brasil.
FAU - Budni, Josiane
AU  - Budni J
AD  - Laboratorio de Neurodegeneracao, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      888806-000, Criciuma, SC, Brasil.
FAU - Kapczinski, Flavio
AU  - Kapczinski F
AD  - Center for Experimental Models in Psychiatry, Department of Psychiatry and 
      Behavioral Sciences, The University of Texas Medical School at Houston, 77030, 
      Houston, TX, USA Laboratorio de Psiquiatria Molecular, Hospital de Clinicas de 
      Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035003, Porto Alegre, 
      RS, Brasil.
FAU - Quevedo, Joao
AU  - Quevedo J
AD  - Center for Experimental Models in Psychiatry, Department of Psychiatry and 
      Behavioral Sciences, The University of Texas Medical School at Houston, 77030, 
      Houston, TX, USA Laboratorio de Neurociencias, Programa de Pos-Graduacao em 
      Ciencias da Saude, Unidade Academica de Ciencias da Saude, Universidade do 
      Extremo Sul Catarinense, 888806-000, Criciuma, SC, Brasil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140605
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Vitamins)
RN  - 8059-24-3 (Vitamin B 6)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/biosynthesis
MH  - Cognition Disorders/*prevention & control
MH  - Gene Expression Profiling
MH  - Hippocampus/pathology
MH  - Humans
MH  - Male
MH  - Memory
MH  - Meningitis, Pneumococcal/*complications
MH  - Rats, Wistar
MH  - Vitamin B 6/*administration & dosage
MH  - Vitamins/*administration & dosage
OTO - NOTNLM
OT  - BDNF
OT  - Pneumococcal meningitis
OT  - memory
OT  - vitamin B6
EDAT- 2014/06/07 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/06/07 06:00
PHST- 2014/06/07 06:00 [entrez]
PHST- 2014/06/07 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 1535370214535896 [pii]
AID - 10.1177/1535370214535896 [doi]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2014 Oct;239(10):1360-5. doi: 10.1177/1535370214535896. 
      Epub 2014 Jun 5.