PMID- 24903192
OWN - NLM
STAT- MEDLINE
DCOM- 20150513
LR  - 20140711
IS  - 1421-9786 (Electronic)
IS  - 1015-9770 (Linking)
VI  - 37
IP  - 5
DP  - 2014
TI  - Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in 
      cervical artery dissection: a meta-analysis.
PG  - 313-22
LID - 10.1159/000360753 [doi]
AB  - BACKGROUND: Cervical artery dissection (CAD) is a recognized cause of ischemic 
      stroke. Hyperhomocysteinemia (HHcy), i.e. an elevated concentration of plasma 
      homocysteine, is identified as an independent risk factor for stroke prevalence. 
      However, an association between HHcy and CAD has so far remained unknown. 
      METHODS: A meta-analysis was performed to analyze the association between HHcy 
      and CAD as well as the relevance of the C677T polymorphism of 
      methylenetetrahydrofolate reductase (MTHFR), the key enzyme in homocysteine 
      metabolism during CAD. We searched PubMed and Embase for studies reporting 
      homocysteine concentrations or MTHFR genotype frequencies in CAD patients from 
      1990 to 2013. Outcomes were extracted from studies meeting the inclusion criteria 
      and were subjected to a meta-analysis by the random-effect model. Heterogeneity 
      was assessed by the I(2) test. RESULTS: Eight case-control studies with 2,146 
      individuals fulfilled the required criteria and were included in the 
      meta-analysis. HHcy was found to be significantly associated with CAD (pooled 
      standardized mean difference: 0.96; 95% confidence interval, CI: 0.42-1.49; p < 
      0.01). We also found a significantly increased risk of CAD in individuals with 
      the MTHFR C677T polymorphism by both the recessive model (TT vs. CT+CC; odds 
      ratio, OR = 1.81; 95% CI: 1.22-2.67; p = 0.003) and the dominant model (TT+CT vs. 
      CC; OR = 1.47; 95% CI: 1.08-1.99; p = 0.014). CONCLUSION: Our data suggest 
      positive correlations between HHcy and CAD and between the C677T polymorphism of 
      MTHFR and CAD.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Luo, Hongzhi
AU  - Luo H
AD  - Department of Physiology and Pathophysiology, School of Basic Medical Sciences, 
      Peking University, Beijing, PR China.
FAU - Liu, Bo
AU  - Liu B
FAU - Hu, Jing
AU  - Hu J
FAU - Wang, Xian
AU  - Wang X
FAU - Zhan, Siyan
AU  - Zhan S
FAU - Kong, Wei
AU  - Kong W
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20140604
PL  - Switzerland
TA  - Cerebrovasc Dis
JT  - Cerebrovascular diseases (Basel, Switzerland)
JID - 9100851
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
RN  - Homocysteinemia
SB  - IM
MH  - Arteries/*physiopathology
MH  - Case-Control Studies
MH  - Coronary Artery Disease/complications
MH  - *Genetic Predisposition to Disease
MH  - *Genotype
MH  - Humans
MH  - Hyperhomocysteinemia/complications/*diagnosis
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Neck
MH  - Odds Ratio
MH  - Polymorphism, Genetic/*genetics
MH  - Risk
EDAT- 2014/06/07 06:00
MHDA- 2015/05/15 06:00
CRDT- 2014/06/07 06:00
PHST- 2013/09/21 00:00 [received]
PHST- 2014/02/18 00:00 [accepted]
PHST- 2014/06/07 06:00 [entrez]
PHST- 2014/06/07 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
AID - 000360753 [pii]
AID - 10.1159/000360753 [doi]
PST - ppublish
SO  - Cerebrovasc Dis. 2014;37(5):313-22. doi: 10.1159/000360753. Epub 2014 Jun 4.