PMID- 24903343
OWN - NLM
STAT- MEDLINE
DCOM- 20150528
LR  - 20211021
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Print)
IS  - 1569-5794 (Linking)
VI  - 30
IP  - 7
DP  - 2014 Oct
TI  - Progression of diffuse myocardial fibrosis assessed by cardiac magnetic resonance 
      T(1) mapping.
PG  - 1339-46
LID - 10.1007/s10554-014-0459-z [doi]
AB  - To evaluate long-term changes in diffuse myocardial fibrosis using cardiac 
      magnetic resonance (CMR) with late gadolinium enhancement (LGE) and T1 mapping. 
      Patients with chronic stable cardiomyopathy and stable clinical status (n = 52) 
      underwent repeat CMR at a 6 month or greater follow up interval and had LGE and 
      left ventricular (LV) T1 mapping CMR. Diffuse myocardial fibrosis (excluding 
      areas of focal myocardial scar) was assessed by post gadolinium myocardial T1 
      times. Mean baseline age of 52 patients (66 % male) was 35 +/- 19 years with a mean 
      interval between CMR examinations of 2.0 +/- 0.8 years. CMR parameters, including 
      LV mass and ejection fraction, showed no change at follow-up CMR (p > 0.05). LVT1 
      times (excluding focal scar) decreased over the study interval (from 468 +/- 106 to 
      434 +/- 82 ms, p = 0.049). 38 Patients had no visual LGE-, while 14 were LGE+. For 
      LGE- patients, greater change in LV mass and end systolic volume index were 
      associated with change in T1 time (beta = -2.03 ms/g/m(2), p = 0.035 and beta = 2.1 
      ms/mL/m(2), p = 0.029, respectively). For LGE+ patients, scar size was stable 
      between CMR1 and CMR2 (10.7 +/- 13.8 and 11.5 +/- 13.9 g, respectively, p = 0.32). 
      These results suggest that diffuse myocardial fibrosis, as assessed by T1 
      mapping, progresses over time in patients with chronic stable cardiomyopathy.
FAU - Yi, Colin J
AU  - Yi CJ
AD  - Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive, 
      Rm 10/1C355, Bethesda, MD, 20892, USA.
FAU - Yang, Eunice
AU  - Yang E
FAU - Lai, Shenghan
AU  - Lai S
FAU - Gai, Neville
AU  - Gai N
FAU - Liu, Chia
AU  - Liu C
FAU - Liu, Songtao
AU  - Liu S
FAU - Zimmerman, Stefan L
AU  - Zimmerman SL
FAU - Lima, Joao A C
AU  - Lima JA
FAU - Bluemke, David A
AU  - Bluemke DA
LA  - eng
GR  - ZIA CL090019-04/Intramural NIH HHS/United States
GR  - ZIA EB000072-04/Intramural NIH HHS/United States
PT  - Journal Article
DEP - 20140606
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cardiomyopathies/*pathology/physiopathology
MH  - Chronic Disease
MH  - Disease Progression
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Stroke Volume
MH  - Time Factors
MH  - Ventricular Function, Left
MH  - Young Adult
PMC - PMC4169726
MID - NIHMS602855
EDAT- 2014/06/07 06:00
MHDA- 2015/05/29 06:00
PMCR- 2015/10/01
CRDT- 2014/06/07 06:00
PHST- 2014/03/18 00:00 [received]
PHST- 2014/05/22 00:00 [accepted]
PHST- 2014/06/07 06:00 [entrez]
PHST- 2014/06/07 06:00 [pubmed]
PHST- 2015/05/29 06:00 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - 10.1007/s10554-014-0459-z [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2014 Oct;30(7):1339-46. doi: 10.1007/s10554-014-0459-z. 
      Epub 2014 Jun 6.