PMID- 24903987
OWN - NLM
STAT- MEDLINE
DCOM- 20150114
LR  - 20211021
IS  - 1862-1783 (Electronic)
IS  - 1673-1581 (Print)
IS  - 1673-1581 (Linking)
VI  - 15
IP  - 6
DP  - 2014 Jun
TI  - Is right ventricular mid-septal pacing superior to apical pacing in patients with 
      high degree atrio-ventricular block and moderately depressed left ventricular 
      function?
PG  - 507-14
LID - 10.1631/jzus.B1400034 [doi]
AB  - OBJECTIVE: We are aimed to investigate whether right ventricular mid-septal 
      pacing (RVMSP) is superior to conventional right ventricular apical pacing (RVAP) 
      in improving clinical functional capacity and left ventricular ejection fraction 
      (LVEF) for patients with high-degree atrio-ventricular block and moderately 
      depressed left ventricle (LV) function. METHODS: Ninety-two patients with 
      high-degree atrio-ventricular block and moderately reduced LVEF (ranging from 35% 
      to 50%) were randomly allocated to RVMSP (n=45) and RVAP (n=47). New York Heart 
      Association (NYHA) functional class, echocardiographic LVEF, and distance during 
      a 6-min walk test (6MWT) were determined at 18 months after pacemaker 
      implantation. Serum levels of N-terminal pro-brain natriuretic peptide 
      (NT-proBNP) were measured using an enzyme-linked immunosorbent assay (ELISA) kit. 
      RESULTS: Compared with baseline, NYHA functional class remained unchanged at 18 
      months, distance during 6MWT (485 m vs. 517 m) and LVEF (36.7% vs. 41.8%) were 
      increased, but BNP levels were reduced (2352 pg/ml vs. 710 pg/ml) in the RVMSP 
      group compared with those in the RVAP group, especially in patients with LVEF 
      35%-40% (for all comparisons, P<0.05). However, clinical function capacity and LV 
      function measurements were not significantly changed in patients with RVAP, 
      despite the pacing measurements being similar in both groups, such as R-wave 
      amplitude and capture threshold. CONCLUSIONS: RVMSP provides a better clinical 
      utility, compared with RVAP, in patients with high-degree atrioventricular block 
      and moderately depressed LV function whose LVEF levels ranged from 35% to 40%.
FAU - Chen, Kang
AU  - Chen K
AD  - Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai 200025, China; Outpatient Department, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
FAU - Mao, Ye
AU  - Mao Y
FAU - Liu, Shao-hua
AU  - Liu SH
FAU - Wu, Qiong
AU  - Wu Q
FAU - Luo, Qing-zhi
AU  - Luo QZ
FAU - Pan, Wen-qi
AU  - Pan WQ
FAU - Jin, Qi
AU  - Jin Q
FAU - Zhang, Ning
AU  - Zhang N
FAU - Ling, Tian-you
AU  - Ling TY
FAU - Chen, Ying
AU  - Chen Y
FAU - Gu, Gang
AU  - Gu G
FAU - Shen, Wei-feng
AU  - Shen WF
FAU - Wu, Li-qun
AU  - Wu LQ
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Zhejiang Univ Sci B
JT  - Journal of Zhejiang University. Science. B
JID - 101236535
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Atrioventricular Block/complications/*diagnosis/*therapy
MH  - Biomarkers/blood
MH  - Cardiac Pacing, Artificial/*methods
MH  - Female
MH  - Heart Ventricles
MH  - Humans
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/*diagnosis/etiology/*prevention & control
PMC - PMC4116854
OTO - NOTNLM
OT  - Apical pacing
OT  - Impaired heart function
OT  - Mid-septal pacing
COIS- Compliance with ethics guidelines: Kang CHEN, Ye MAO, Shao-hua LIU, Qiong WU, 
      Qing-zhi LUO, Wen-qi PAN, Qi JIN, Ning ZHANG, Tian-you LING, Ying CHEN, Gang GU, 
      Wei-feng SHEN, and Li-qun WU declare that they have no conflict of interest. All 
      procedures followed were in accordance with the ethical standards of the 
      responsible committee on human experimentation (institutional and national) and 
      with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent 
      was obtained from all patients for being included in the study. Additional 
      informed consent was obtained from all patients for which identifying information 
      is included in this article.
EDAT- 2014/06/07 06:00
MHDA- 2015/01/15 06:00
PMCR- 2014/06/01
CRDT- 2014/06/07 06:00
PHST- 2014/06/07 06:00 [entrez]
PHST- 2014/06/07 06:00 [pubmed]
PHST- 2015/01/15 06:00 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - 10.1631/jzus.B1400034 [doi]
PST - ppublish
SO  - J Zhejiang Univ Sci B. 2014 Jun;15(6):507-14. doi: 10.1631/jzus.B1400034.