PMID- 24904430
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 5
DP  - 2014
TI  - Dendritic cells in atherosclerotic inflammation: the complexity of functions and 
      the peculiarities of pathophysiological effects.
PG  - 196
LID - 10.3389/fphys.2014.00196 [doi]
LID - 196
AB  - Atherosclerosis is considered as a chronic disease of arterial wall, with a 
      strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in 
      the initiation of proatherogenic inflammatory response. Mature DCs present 
      self-antigens thereby supporting differentiation of naive T cells to effector 
      cells that further propagate atherosclerotic inflammation. Regulatory T cells 
      (Tregs) can suppress proinflammatory function of mature DCs. In contrast, 
      immature DCs are able to induce Tregs and prevent differentiation of naive T 
      cells to proinflammatory effector T cells by initiating apoptosis and anergy in 
      naive T cells. Indeed, immature DCs showed tolerogenic and anti-inflammatory 
      properties. Thus, DCs play a double role in atherosclerosis: mature DCs are 
      proatherogenic while immature DCs appear to be anti-atherogenic. Tolerogenic and 
      anti-inflammatory capacity of immature DCs can be therefore utilized for the 
      development of new immunotherapeutic strategies against atherosclerosis.
FAU - Chistiakov, Dimitry A
AU  - Chistiakov DA
AD  - Department of Medical Nanobiotechnology, Pirogov Russian State Medical University 
      Moscow, Russia.
FAU - Sobenin, Igor A
AU  - Sobenin IA
AD  - Skolkovo Innovative Center, Institute for Atherosclerosis Research Moscow, Russia 
      ; Institute of General Pathology and Pathophysiology, Russian Academy of Sciences 
      Moscow, Russia ; Laboratory of Medical Genetics, Russian Cardiology Research and 
      Production Complex Moscow, Russia.
FAU - Orekhov, Alexander N
AU  - Orekhov AN
AD  - Skolkovo Innovative Center, Institute for Atherosclerosis Research Moscow, Russia 
      ; Institute of General Pathology and Pathophysiology, Russian Academy of Sciences 
      Moscow, Russia.
FAU - Bobryshev, Yuri V
AU  - Bobryshev YV
AD  - Skolkovo Innovative Center, Institute for Atherosclerosis Research Moscow, Russia 
      ; Faculty of Medicine, School of Medical Sciences, University of New South Wales, 
      Kensington, Sydney NSW, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140527
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC4034414
OTO - NOTNLM
OT  - arteries
OT  - atherogenesis
OT  - atherosclerosis
OT  - dendritic cells
OT  - immune reactions
OT  - inflammation
EDAT- 2014/06/07 06:00
MHDA- 2014/06/07 06:01
PMCR- 2014/05/27
CRDT- 2014/06/07 06:00
PHST- 2014/02/12 00:00 [received]
PHST- 2014/05/09 00:00 [accepted]
PHST- 2014/06/07 06:00 [entrez]
PHST- 2014/06/07 06:00 [pubmed]
PHST- 2014/06/07 06:01 [medline]
PHST- 2014/05/27 00:00 [pmc-release]
AID - 10.3389/fphys.2014.00196 [doi]
PST - epublish
SO  - Front Physiol. 2014 May 27;5:196. doi: 10.3389/fphys.2014.00196. eCollection 
      2014.