PMID- 24904573
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 5
DP  - 2014
TI  - Dendritic Cell Therapy in an Allogeneic-Hematopoietic Cell Transplantation 
      Setting: An Effective Strategy toward Better Disease Control?
PG  - 218
LID - 10.3389/fimmu.2014.00218 [doi]
LID - 218
AB  - Hematopoietic cell transplantation (HCT) is a last treatment resort and only 
      potentially curative treatment option for several hematological malignancies 
      resistant to chemotherapy. The induction of profound immune regulation after 
      allogeneic HCT is imperative to prevent graft-versus-host reactions and, at the 
      same time, allow protective immune responses against pathogens and against tumor 
      cells. Dendritic cells (DCs) are highly specialized antigen-presenting cells that 
      are essential in regulating this balance and are of major interest as a tool to 
      modulate immune responses in the complex and challenging phase of immune 
      reconstitution early after allo-HCT. This review focuses on the use of DC 
      vaccination to prevent cancer relapses early after allo-HCT. It describes the 
      role of host and donor-DCs, various vaccination strategies, different DC subsets, 
      antigen loading, DC maturation/activation, and injection sites and dose. At last, 
      clinical trials using DC vaccination post-allo-HCT and the future perspectives of 
      DC vaccination in combination with other cancer immunotherapies are discussed.
FAU - Plantinga, Maud
AU  - Plantinga M
AD  - Utrecht - Dendritic cells AgaiNst CancEr (U-DANCE), Laboratory of Translational 
      Immunology, Department of Immunology, University Medical Centre Utrecht , Utrecht 
      , Netherlands.
FAU - de Haar, Colin
AU  - de Haar C
AD  - Utrecht - Dendritic cells AgaiNst CancEr (U-DANCE), Laboratory of Translational 
      Immunology, Department of Immunology, University Medical Centre Utrecht , Utrecht 
      , Netherlands.
FAU - Nierkens, Stefan
AU  - Nierkens S
AD  - Utrecht - Dendritic cells AgaiNst CancEr (U-DANCE), Laboratory of Translational 
      Immunology, Department of Immunology, University Medical Centre Utrecht , Utrecht 
      , Netherlands.
FAU - Boelens, Jaap Jan
AU  - Boelens JJ
AD  - Utrecht - Dendritic cells AgaiNst CancEr (U-DANCE), Laboratory of Translational 
      Immunology, Department of Immunology, University Medical Centre Utrecht , Utrecht 
      , Netherlands ; Pediatric Blood and Marrow Transplantation Program, Department of 
      Immunology, University Medical Centre Utrecht , Utrecht , Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140519
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC4032952
OTO - NOTNLM
OT  - DC-vaccination
OT  - T-cell responses
OT  - disease control
OT  - hematopoietic cell transplantation
OT  - relapse
EDAT- 2014/06/07 06:00
MHDA- 2014/06/07 06:01
PMCR- 2014/01/01
CRDT- 2014/06/07 06:00
PHST- 2014/01/31 00:00 [received]
PHST- 2014/04/30 00:00 [accepted]
PHST- 2014/06/07 06:00 [entrez]
PHST- 2014/06/07 06:00 [pubmed]
PHST- 2014/06/07 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2014.00218 [doi]
PST - epublish
SO  - Front Immunol. 2014 May 19;5:218. doi: 10.3389/fimmu.2014.00218. eCollection 
      2014.