PMID- 24905068
OWN - NLM
STAT- MEDLINE
DCOM- 20150112
LR  - 20220317
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 99
IP  - 9
DP  - 2014 Sep
TI  - The acute effects of interval- Vs continuous-walking exercise on glycemic control 
      in subjects with type 2 diabetes: a crossover, controlled study.
PG  - 3334-42
LID - 10.1210/jc.2014-1837 [doi]
AB  - CONTEXT: Glycemic control improves with physical activity, but the optimal 
      exercise mode is unknown. OBJECTIVE: The objective of the study was to determine 
      whether interval-based exercise improves postprandial glucose tolerance and 
      free-living glycemia more than oxygen consumption- and time duration-matched 
      continuous exercise. DESIGN: This was a crossover, controlled study with trials 
      performed in randomized order. SETTING: The study was conducted in hospitalized 
      and ambulatory care. PATIENTS: PATIENTS diagnosed with type 2 diabetes mellitus 
      (n=10, no withdrawals) participated in the study. INTERVENTIONS: Subjects 
      performed three 1-hour interventions: 1) interval walking (IW; repeated cycles of 
      3 min of slow and fast walking); 2) continuous walking (CW); and 3) control 
      (CON). Oxygen consumption (VO2) was measured continuously to match mean VO2 
      between exercise sessions ( approximately 75% VO2peak). MAIN OUTCOME MEASURES: A mixed-meal 
      tolerance test (MMTT; 450 kcal, 55% carbohydrate) with stable glucose isotopic 
      tracers was provided after each intervention, and glucose kinetics were measured 
      during the following 4 hours. Free-living glycemic control was assessed for 
      approximately 32 hours after the MMTT using continuous glucose monitoring. 
      RESULTS: VO2 was well matched between the exercise interventions. IW decreased 
      the mean and maximal incremental plasma glucose during the MMTT when compared 
      with the CON (mean 1.2 +/- 0.4 vs 2.0 +/- 0.5 mmol/L, P < .001; maximal 3.7 +/- 0.6 vs 
      4.6 +/- 0.7 mmol/L, P = .005) and mean when compared with CW (1.7 +/- 0.4 mmol/L, P = 
      .02). No differences in the mean or maximal incremental plasma glucose values 
      were seen between the CW and CON. The metabolic clearance rate of glucose during 
      the MMTT was increased in the IW compared with CW (P = .049) and CON (P < .001). 
      Continuous glucose monitoring mean glucose was reduced in IW compared with CW for 
      the rest of the intervention day (8.2 +/- 0.4 vs 9.3 +/- 0.7 mmol/L, P = .03), 
      whereas no differences were found between IW and CW the following day. 
      CONCLUSIONS: One interval-based exercise session improves glycemic control in 
      type 2 diabetes mellitus subjects when compared with an oxygen consumption- and 
      time duration-matched continuous exercise session.
FAU - Karstoft, Kristian
AU  - Karstoft K
AD  - The Centre of Inflammation and Metabolism (K.K., B.K.P., T.P.J.S.) and The Centre 
      for Physical Activity Research (K.K., B.K.P., T.P.J.S.), Department of Infectious 
      Diseases and Clinical Medical Research Center, Rigshospitalet, Faculty of Health 
      Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark; Department of 
      Biomedical Sciences (C.S.C., T.P.J.S.), Panum Institute, University of 
      Copenhagen, DK-2200 Copenhagen, Denmark; and Nordic Bioscience (C.S.C.), DK-2730 
      Herlev, Denmark.
FAU - Christensen, Camilla S
AU  - Christensen CS
FAU - Pedersen, Bente K
AU  - Pedersen BK
FAU - Solomon, Thomas P J
AU  - Solomon TP
LA  - eng
SI  - ClinicalTrials.gov/NCT01987258
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140606
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - Cross-Over Studies
MH  - Diabetes Mellitus, Type 2/metabolism/*physiopathology
MH  - Dietary Carbohydrates/administration & dosage
MH  - Exercise/*physiology
MH  - Female
MH  - Glucagon/blood
MH  - Humans
MH  - Hyperglycemia/metabolism/*physiopathology
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption/*physiology
MH  - Walking/*physiology
EDAT- 2014/06/07 06:00
MHDA- 2015/01/13 06:00
CRDT- 2014/06/07 06:00
PHST- 2014/06/07 06:00 [entrez]
PHST- 2014/06/07 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 10.1210/jc.2014-1837 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2014 Sep;99(9):3334-42. doi: 10.1210/jc.2014-1837. Epub 
      2014 Jun 6.