PMID- 24905321
OWN - NLM
STAT- MEDLINE
DCOM- 20150205
LR  - 20220408
IS  - 2299-5684 (Electronic)
IS  - 1734-1140 (Linking)
VI  - 66
IP  - 1
DP  - 2014 Feb
TI  - Pharmacokinetics of oxycodone hydrochloride and three of its metabolites after 
      intravenous administration in Chinese patients with pain.
PG  - 153-8
LID - S1734-1140(14)00024-3 [pii]
LID - 10.1016/j.pharep.2013.08.012 [doi]
AB  - OBJECTIVES: The aim of this study is to evaluate the pharmacokinetic profile of 
      oxycodone and three of its metabolites, noroxycodone, oxymorphone and 
      noroxymorphone after intravenous administration in Chinese patients with pain. 
      METHODS: Forty-two subjects were assigned to receive intravenous administration 
      of oxycodone hydrochloride of 2.5, 5 or 10 mg. Plasma and urine samples were 
      collected for up to 24 h after intravenous administration of oxycodone 
      hydrochloride. RESULTS: Pharmacokinetic parameters showed that mean values of 
      C(max), AUC(0-t) and AUC(0-infinity) of oxycodone were dose dependent, whereas Tmax and 
      t(1/2) were not. The mean AUC(0-t) ratio of noroxycodone to oxycodone ranged from 
      0.35 to 0.42 over three doses, and those of noroxymorphone, or oxymorphone, to 
      oxycodone were ranging of 0.06-0.08 and 0.007-0.008, respectively. Oxycodone and 
      its three metabolites were excreted from urine. Approximately 10% of unchanged 
      oxycodone was recovered in 24 h. Most adverse events (AEs) reported were mild to 
      moderate. The frequently occurred AEs were dizziness, nausea, vomiting, 
      drowsiness and fatigue. No dose-related AEs were found. CONCLUSION: Our 
      pharmacokinetics of oxycodone injection in Chinese patients with pain strongly 
      support continued development of oxycodone as an effective analgesic drug in 
      China.
CI  - Copyright (c) 2014 Institute of Pharmacology, Polish Academy of Sciences. Published 
      by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
FAU - Hao, Guang-Tao
AU  - Hao GT
AD  - Department of Pharmacology, Affiliated Hospital of the Academy of Military 
      Medical Sciences, Beijing, China.
FAU - Zhou, Hai-Yan
AU  - Zhou HY
AD  - Department of Pharmacy, Cancer Institute and Hospital, Chinese Academy of Medical 
      Sciences, Beijing, China.
FAU - Gao, Hong-Zhi
AU  - Gao HZ
AD  - Department of Pharmacology, Affiliated Hospital of the Academy of Military 
      Medical Sciences, Beijing, China.
FAU - Qu, Heng-Yan
AU  - Qu HY
AD  - Department of Pharmacology, Affiliated Hospital of the Academy of Military 
      Medical Sciences, Beijing, China.
FAU - Liang, Yu-Guang
AU  - Liang YG
AD  - Department of Pharmacology, Affiliated Hospital of the Academy of Military 
      Medical Sciences, Beijing, China.
FAU - Li, Yuan-Yuan
AU  - Li YY
AD  - Department of Pharmacology, Affiliated Hospital of the Academy of Military 
      Medical Sciences, Beijing, China.
FAU - Dong, Rui-Hua
AU  - Dong RH
AD  - Department of Pharmacology, Affiliated Hospital of the Academy of Military 
      Medical Sciences, Beijing, China.
FAU - Zhang, Li-Juan
AU  - Zhang LJ
AD  - Department of Pharmacology, Affiliated Hospital of the Academy of Military 
      Medical Sciences, Beijing, China.
FAU - Wang, Xiao-Fang
AU  - Wang XF
AD  - Department of Pharmacology, Affiliated Hospital of the Academy of Military 
      Medical Sciences, Beijing, China.
FAU - Liu, Ze-Yuan
AU  - Liu ZY
AD  - Department of Pharmacology, Affiliated Hospital of the Academy of Military 
      Medical Sciences, Beijing, China. Electronic address: YLS307@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140201
PL  - Switzerland
TA  - Pharmacol Rep
JT  - Pharmacological reports : PR
JID - 101234999
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Morphinans)
RN  - 95Q949779D (noroxycodone)
RN  - 9NZ7111A9O (noroxymorphone)
RN  - 9VXA968E0C (Oxymorphone)
RN  - CD35PMG570 (Oxycodone)
SB  - IM
MH  - Adult
MH  - Analgesics, Opioid/*pharmacokinetics
MH  - Area Under Curve
MH  - Female
MH  - Humans
MH  - Injections, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Morphinans/pharmacokinetics
MH  - Oxycodone/adverse effects/*pharmacokinetics
MH  - Oxymorphone/pharmacokinetics
MH  - Pain/*drug therapy
OTO - NOTNLM
OT  - Chinese patients with pain
OT  - Metabolites
OT  - Oxycodone
OT  - Pharmacokinetics
EDAT- 2014/06/07 06:00
MHDA- 2015/02/06 06:00
CRDT- 2014/06/07 06:00
PHST- 2012/10/23 00:00 [received]
PHST- 2013/07/29 00:00 [revised]
PHST- 2013/08/13 00:00 [accepted]
PHST- 2014/06/07 06:00 [entrez]
PHST- 2014/06/07 06:00 [pubmed]
PHST- 2015/02/06 06:00 [medline]
AID - S1734-1140(14)00024-3 [pii]
AID - 10.1016/j.pharep.2013.08.012 [doi]
PST - ppublish
SO  - Pharmacol Rep. 2014 Feb;66(1):153-8. doi: 10.1016/j.pharep.2013.08.012. Epub 2014 
      Feb 1.