PMID- 24905648
OWN - NLM
STAT- MEDLINE
DCOM- 20150219
LR  - 20140701
IS  - 1879-3150 (Electronic)
IS  - 0041-0101 (Linking)
VI  - 87
DP  - 2014 Sep
TI  - Studies on the teratogenicity of anabasine in a rat model.
PG  - 32-7
LID - S0041-0101(14)00152-4 [pii]
LID - 10.1016/j.toxicon.2014.05.018 [doi]
AB  - A number of plant toxins have been shown to be teratogenic to livestock. The 
      teratogenic action of some of these alkaloids is mediated by nicotinic 
      acetylcholine receptors (nAChR). However, for many of these alkaloids it is 
      difficult to obtain sufficient quantities of individual alkaloids to perform 
      teratology studies in livestock species. Therefore the objective of this study 
      was to determine if a rat model can be utilized to characterize the teratogenic 
      nature of individual plant toxins that are nAChR agonists. In this study, we 
      evaluated the teratogenicity of anabasine by feeding pregnant rats 
      anabasine-containing rodent chow from gestational day (GD) 6-21. On GD21, the 
      dams were euthanized and the gravid uteri were removed. The gravid uteri and 
      individual pups were weighed. The pups were evaluated for bone malformations 
      including cleft palate and scoliosis. Overall, the results of this study suggest 
      that the rat is not a good model to study the teratogenicity of plant toxins that 
      are nAChR agonists. It is possible that in the rat model, anabasine administered 
      orally via the chow may not result in sufficient reduction in fetal movement to 
      cause the significant malformations observed in livestock species.
CI  - Published by Elsevier Ltd.
FAU - Welch, K D
AU  - Welch KD
AD  - USDA-ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N., Logan, UT 84341, 
      USA. Electronic address: Kevin.Welch@ars.usda.gov.
FAU - Lee, S T
AU  - Lee ST
AD  - USDA-ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N., Logan, UT 84341, 
      USA.
FAU - Panter, K E
AU  - Panter KE
AD  - USDA-ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N., Logan, UT 84341, 
      USA.
FAU - Gardner, D R
AU  - Gardner DR
AD  - USDA-ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N., Logan, UT 84341, 
      USA.
FAU - Knoppel, E L
AU  - Knoppel EL
AD  - USDA-ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N., Logan, UT 84341, 
      USA.
FAU - Green, B T
AU  - Green BT
AD  - USDA-ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N., Logan, UT 84341, 
      USA.
FAU - Hammond, C K
AU  - Hammond CK
AD  - USDA-ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N., Logan, UT 84341, 
      USA.
FAU - Hammond, Z J
AU  - Hammond ZJ
AD  - USDA-ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N., Logan, UT 84341, 
      USA.
FAU - Pfister, J A
AU  - Pfister JA
AD  - USDA-ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N., Logan, UT 84341, 
      USA.
LA  - eng
PT  - Journal Article
DEP - 20140604
PL  - England
TA  - Toxicon
JT  - Toxicon : official journal of the International Society on Toxinology
JID - 1307333
RN  - 0 (Teratogens)
RN  - 0 (Toxins, Biological)
RN  - LMS11II2LO (Anabasine)
SB  - IM
MH  - Abnormalities, Drug-Induced/pathology
MH  - Anabasine/*toxicity
MH  - Animals
MH  - Body Weight/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Eating/drug effects
MH  - Female
MH  - Male
MH  - Pregnancy
MH  - Rats
MH  - Reproduction/drug effects
MH  - Teratogens/*toxicity
MH  - Toxins, Biological/toxicity
OTO - NOTNLM
OT  - Anabasine
OT  - Nicotinic acetylcholine receptor
OT  - Plant toxins
OT  - Rat
OT  - Teratogen
EDAT- 2014/06/07 06:00
MHDA- 2015/02/20 06:00
CRDT- 2014/06/07 06:00
PHST- 2014/04/22 00:00 [received]
PHST- 2014/05/21 00:00 [revised]
PHST- 2014/05/23 00:00 [accepted]
PHST- 2014/06/07 06:00 [entrez]
PHST- 2014/06/07 06:00 [pubmed]
PHST- 2015/02/20 06:00 [medline]
AID - S0041-0101(14)00152-4 [pii]
AID - 10.1016/j.toxicon.2014.05.018 [doi]
PST - ppublish
SO  - Toxicon. 2014 Sep;87:32-7. doi: 10.1016/j.toxicon.2014.05.018. Epub 2014 Jun 4.